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Condensed Consolidated Balance Sheets (USD $)
In Thousands, unless otherwise specified
Mar. 31, 2015
Dec. 31, 2014
Current assets:    
Cash and cash equivalents $ 120,844us-gaap_CashAndCashEquivalentsAtCarryingValue $ 120,841us-gaap_CashAndCashEquivalentsAtCarryingValue
Receivables from collaboration 4,282us-gaap_AccountsReceivableNetCurrent 50,436us-gaap_AccountsReceivableNetCurrent
Inventory 16,789us-gaap_InventoryNet 9,670us-gaap_InventoryNet
Prepaid expenses and other current assets 16,375us-gaap_PrepaidExpenseAndOtherAssetsCurrent 20,206us-gaap_PrepaidExpenseAndOtherAssetsCurrent
Total current assets 158,290us-gaap_AssetsCurrent 201,153us-gaap_AssetsCurrent
Property and equipment - net 193,454us-gaap_PropertyPlantAndEquipmentNet 192,127us-gaap_PropertyPlantAndEquipmentNet
Deferred products costs from collaboration 6,251us-gaap_DeferredCosts  
Other assets 2,027us-gaap_OtherAssetsNoncurrent 1,159us-gaap_OtherAssetsNoncurrent
Total 360,022us-gaap_Assets 394,439us-gaap_Assets
Current liabilities:    
Accounts payable 3,302us-gaap_AccountsPayableCurrent 7,394us-gaap_AccountsPayableCurrent
Accrued expenses and other current liabilities 12,381us-gaap_AccruedLiabilitiesCurrent 26,206us-gaap_AccruedLiabilitiesCurrent
Facility financing obligation 73,368us-gaap_OtherLongTermDebtCurrent 72,995us-gaap_OtherLongTermDebtCurrent
Senior convertible notes 99,593us-gaap_ConvertibleNotesPayableCurrent 99,355us-gaap_ConvertibleNotesPayableCurrent
Deferred product sales from collaboration 7,050us-gaap_OtherDeferredCreditsCurrent  
Deferred payments from collaboration 185,059us-gaap_DeferredRevenueCurrent 197,403us-gaap_DeferredRevenueCurrent
Total current liabilities 380,753us-gaap_LiabilitiesCurrent 403,353us-gaap_LiabilitiesCurrent
Note payable to principal stockholder 49,521us-gaap_NotesPayableRelatedPartiesNoncurrent 49,521us-gaap_NotesPayableRelatedPartiesNoncurrent
Other liabilities 26,779us-gaap_OtherLiabilitiesNoncurrent 15,335us-gaap_OtherLiabilitiesNoncurrent
Total liabilities 457,053us-gaap_Liabilities 468,209us-gaap_Liabilities
Commitments and contingencies      
Stockholders' equity (deficit):    
Undesignated preferred stock, $0.01 par value - 10,000,000 shares authorized; no shares issued or outstanding at March 31, 2015 and December 31, 2014      
Common stock, $0.01 par value - 550,000,000 shares authorized at March 31, 2015 and December 31, 2014; 409,116,346 and 406,059,089 shares issued and outstanding at March 31, 2015 and December 31, 2014, respectively 4,090us-gaap_CommonStockValue 4,061us-gaap_CommonStockValue
Additional paid-in capital 2,424,347us-gaap_AdditionalPaidInCapitalCommonStock 2,416,967us-gaap_AdditionalPaidInCapitalCommonStock
Accumulated other comprehensive loss (21)us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax (14)us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax
Accumulated deficit (2,525,447)us-gaap_RetainedEarningsAccumulatedDeficit (2,494,784)us-gaap_RetainedEarningsAccumulatedDeficit
Total stockholders' (deficit) (97,031)us-gaap_StockholdersEquity (73,770)us-gaap_StockholdersEquity
Total $ 360,022us-gaap_LiabilitiesAndStockholdersEquity $ 394,439us-gaap_LiabilitiesAndStockholdersEquity