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Subsequent Event - Additional Information (Detail) - Entity [Domain] $ / shares in Units, $ in Thousands, shares in Millions |  |  |  | 6 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Aug. 10, 2015 USD ($) $ / shares shares | Aug. 10, 2015 USD ($) d $ / shares shares | Jul. 28, 2015 USD ($) | Aug. 18, 2010 USD ($) d $ / shares | Jun. 30, 2015 USD ($) | Jun. 30, 2014 USD ($) | Dec. 31, 2014 USD ($) | Sep. 23, 2014
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Aggregate principal amount for conversion |  |  |  |  |  | $ 93,500 |  |
License and Collaboration Agreement with Sanofi |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Senior notes, effective interest rate |  |  |  |  |  |  |  | 8.50%
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmnH |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Secured loan facility, amount borrowed |  |  |  |  | $ 15,600 |  |  |
Subsequent Event | License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmnH |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Secured loan facility, amount borrowed |  |  | $ 12,800 |  |  |  |  |
Senior convertible notes due August 15, 2018 | Subsequent Event |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Principal amount | $ 27,700 | $ 27,700 |  |  |  |  |  |
Senior notes, effective interest rate | 5.75% | 5.75% |  |  |  |  |  |
Maturity date |  | Aug. 15, 2018 |  |  |  |  |  |
No of convertible shares |  | 147.0859 |  |  |  |  |  |
Principal amount per share | $ / shares |  | $ 1,000 |  |  |  |  |  |
Conversion price of shares | $ / shares | $ 6.80 | $ 6.80 |  |  |  |  |  |
Percentage of repurchase price |  | 100.00% |  |  |  |  |  |
Debt Instrument, redemption description |  | On or after the date that is one year following the original issue date of the 2018 notes, the Company will have the right to redeem for cash all or part of the 2018 notes if the last reported sale price of its common stock exceeds 130% of the conversion price then in effect for 20 or more trading days during the 30 consecutive trading day period ending on the trading day immediately prior to the date of the redemption notice. The redemption price will equal the sum of 100% of the principal amount of the 2018 notes to be redeemed, plus accrued and unpaid interest. |  |  |  |  |  |
Percentage of conversion price equaling stock price |  | 130.00% |  |  |  |  |  |
Number of trading days | d |  | 20 |  |  |  |  |  |
Consecutive trading days |  | 30 days |  |  |  |  |  |
Senior convertible notes due August 15, 2015 |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Principal amount |  |  |  | $ 100,000 | $ 100,000 |  | $ 100,000 |
Senior notes, effective interest rate |  |  |  |  | 5.75% |  |  |
Maturity date |  |  |  |  | Aug. 15, 2015 |  |  |
No of convertible shares |  |  |  | 147.0859 |  |  |  |
Principal amount per share | $ / shares |  |  |  | $ 1,000 |  |  |  |
Conversion price of shares | $ / shares |  |  |  | $ 6.80 |  |  |  |
Percentage of repurchase price |  |  |  | 100.00% |  |  |  |
Percentage of conversion price equaling stock price |  |  |  | 150.00% |  |  |  |
Number of trading days | d |  |  |  | 20 |  |  |  |
Consecutive trading days |  |  |  | 30 days |  |  |  |
Long term note payable |  |  |  |  | $ 27,700 |  |  |
Senior convertible notes due August 15, 2015 | Issuance Of Common Stock In Exchange For 2015 Notes |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Long term note payable |  |  |  |  | $ 8,000 |  |  |
Senior convertible notes due August 15, 2015 | Subsequent Event |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Conversion price of shares | $ / shares | $ 4.40 | $ 4.40 |  |  |  |  |  |
Long term note payable | $ 64,300 | $ 64,300 |  |  |  |  |  |
Aggregate principal amount for conversion |  |  | $ 61,800 |  |  |  |  |
Number of shares issued up on conversion of debt | shares | 1.9 | 1.9 |  |  |  |  |  |
Principal amount of debt converted | $ 8,000 | $ 8,000 |  |  |  |  |  |

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- Definition The value of the financial instrument(s) that the original debt is being converted into in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4304-108586 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4332-108586 + Details
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- Definition The amount of the original debt being converted in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4304-108586 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4332-108586 + Details
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- Definition Threshold period of specified consecutive trading days within which common stock price to conversion price of convertible debt instruments must exceed threshold percentage for a specified number of trading days to trigger conversion feature, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References No definition available. + Details
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