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Fair Value of Financial Instruments - Additional Information (Detail) - USD ($) | 6 Months Ended |  |  |  |
--- | --- | --- | --- | --- | ---
Jun. 30, 2015 | Jun. 30, 2014 | Dec. 31, 2014 | Sep. 23, 2014 | Dec. 31, 2013 | Jul. 01, 2013
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |
Cash and cash equivalents | $ 107,187,000 | $ 41,214,000 | $ 120,841,000 |  | $ 70,790,000 |
Cash equivalents, money market funds | 104,700,000 |  | $ 118,500,000 |  |  |
Transfers of assets between fair value measurement | 0 | 0 |  |  |  |
Transfers of liabilities between fair value measurement | 0 | $ 0 |  |  |  |
License and Collaboration Agreement with Sanofi |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |
Maximum secured loan facility |  |  |  | $ 175,000,000 |  |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmnH |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |
Maximum secured loan facility | 175,000,000 |  |  |  |  |
Secured loan facility, amount borrowed | 15,600,000 |  |  |  |  |
Paid-in-kind interest | 200,000 |  |  |  |  |
Milestone Rights Liability | Deerfield | Maximum |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |
Contingent liability for milestone payments |  |  |  |  |  | $ 90,000,000
Fair Value, Inputs, Level 3 | Milestone Rights Liability |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |
Fair value of Milestone Rights | $ 43,900,000 |  |  |  |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Senior convertible notes due December 31, 2019 |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |
Market discount rate | 12.00% |  |  |  |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Milestone Rights Liability |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |
Market discount rate | 15.50% |  |  |  |  |

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- Definition Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Excludes cash and cash equivalents within disposal group and discontinued operation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Cash -URI http://asc.fasb.org/extlink&oid=6506951 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=28358313&loc=d3e6676-107765 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3044-108585 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Cash Equivalents -URI http://asc.fasb.org/extlink&oid=6507016 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.1) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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- Definition Interest rate used to find the present value of an amount to be paid or received in the future as an input to measure fair value. For example, but not limited to, weighted average cost of capital (WACC), cost of capital, cost of equity and cost of debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bbb) -URI http://asc.fasb.org/extlink&oid=36462937&loc=d3e19207-110258 + Details
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- Definition Fair value of financial and nonfinancial obligations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=36462937&loc=d3e19207-110258 + Details
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- Definition Investment in short-term money-market instruments (such as commercial paper, banker's acceptances, repurchase agreements, government securities, certificates of deposit, and so forth) which are highly liquid (that is, readily convertible to known amounts of cash) and so near their maturity that they present an insignificant risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify as cash equivalents by definition. Original maturity means an original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three-years ago does not become a cash equivalent when its remaining maturity is three months. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Cash Equivalents -URI http://asc.fasb.org/extlink&oid=6507016 + Details
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