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Description of Business and Basis of Presentation - Additional Information (Detail) - USD ($)
$ in Thousands, shares in Millions
 1 Months Ended 3 Months Ended 6 Months Ended
Aug. 10, 2015
Aug. 10, 2015
Aug. 11, 2014
Apr. 30, 2015
Mar. 31, 2015
Sep. 30, 2014
Jun. 30, 2015
Dec. 31, 2014
Sep. 23, 2014
Jun. 30, 2014
Dec. 31, 2013
Aug. 18, 2010
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                        
Accumulated deficit             $ (2,554,353) $ (2,494,784)        
Stockholders' deficit             (115,475) (73,770)        
Cash and cash equivalents             107,187 120,841   $ 41,214 $ 70,790  
Principal amount of outstanding debt             244,900          
Amount available for future borrowings             30,100          
Potential proceeds from the exercise of warrants from February 2012 public offering             9,800          
Proceeds from issuance of common stock pursuant to ATM issuance             2,050          
License and Collaboration Agreement with Sanofi                        
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                        
Senior notes, effective interest rate                 8.50%      
Up-front fee           $ 150,000            
Potential milestone payment     $ 725,000       $ 725,000          
Profits and losses sharing percentage     35.00%       35.00%          
Maximum secured loan facility                 $ 175,000      
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmnH                        
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                        
Profits and losses sharing percentage     65.00%       65.00%          
Maximum secured loan facility             $ 175,000          
License and Collaboration Agreement with Sanofi | Manufacturing Milestone Events                        
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                        
Milestone payments earned         $ 50,000              
ATM Agreements                        
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                        
Proceeds from issuance of common stock pursuant to ATM issuance       $ 2,050                
ATM Agreements | Maximum                        
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                        
Offering price of common stock under agreement             47,900          
Senior convertible notes due August 15, 2015                        
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                        
Principal amount of outstanding debt             $ 100,000          
Senior notes, effective interest rate             5.75%          
Maturity date             Aug. 15, 2015          
Principal amount             $ 100,000 $ 100,000       $ 100,000
Senior convertible notes due August 15, 2015 | Subsequent Event                        
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                        
Number of shares issued up on conversion of debt 1.9 1.9                    
Principal amount of debt converted $ 8,000 $ 8,000                    
Senior convertible notes due December 31, 2019 | Deerfield                        
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                        
Senior notes, effective interest rate             9.75%          
Principal amount             $ 60,000          
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset                        
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                        
Senior notes, effective interest rate             8.75%          
Principal amount             $ 20,000          
Senior convertible notes due December 31, 2019 | Deerfield | Minimum | Facility Agreement | Less portion of commitment asset                        
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                        
Available amount of credit facility under covenant restrictions             $ 25,000          
Senior convertible notes due August 15, 2018 | Subsequent Event                        
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                        
Senior notes, effective interest rate 5.75% 5.75%                    
Maturity date   Aug. 15, 2018                    
Principal amount $ 27,700 $ 27,700