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Subsequent Event - Additional Information (Detail) - Entity [Domain] $ / shares in Units, $ in Thousands, shares in Millions					6 Months Ended
	Aug. 10, 2015 USD ($) $ / shares shares	Aug. 10, 2015 USD ($) d $ / shares shares	Jul. 28, 2015 USD ($)	Aug. 18, 2010 USD ($) d $ / shares	Jun. 30, 2015 USD ($)	Jun. 30, 2014 USD ($)	Dec. 31, 2014 USD ($)	Sep. 23, 2014
Subsequent Event [Line Items]
Aggregate principal amount for conversion						$ 93,500
License and Collaboration Agreement with Sanofi
Subsequent Event [Line Items]
Senior notes, effective interest rate								8.50%
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmnH
Subsequent Event [Line Items]
Secured loan facility, amount borrowed					$ 15,600
Subsequent Event | License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmnH
Subsequent Event [Line Items]
Secured loan facility, amount borrowed			$ 12,800
Senior convertible notes due August 15, 2018 | Subsequent Event
Subsequent Event [Line Items]
Principal amount	$ 27,700	$ 27,700
Senior notes, effective interest rate	5.75%	5.75%
Maturity date		Aug. 15, 2018
No of convertible shares		147.0859
Principal amount per share | $ / shares		$ 1,000
Conversion price of shares | $ / shares	$ 6.80	$ 6.80
Percentage of repurchase price		100.00%
Debt Instrument, redemption description		On or after the date that is one year following the original issue date of the 2018 notes, the Company will have the right to redeem for cash all or part of the 2018 notes if the last reported sale price of its common stock exceeds 130% of the conversion price then in effect for 20 or more trading days during the 30 consecutive trading day period ending on the trading day immediately prior to the date of the redemption notice. The redemption price will equal the sum of 100% of the principal amount of the 2018 notes to be redeemed, plus accrued and unpaid interest.
Percentage of conversion price equaling stock price		130.00%
Number of trading days | d		20
Consecutive trading days		30 days
Senior convertible notes due August 15, 2015
Subsequent Event [Line Items]
Principal amount				$ 100,000	$ 100,000		$ 100,000
Senior notes, effective interest rate					5.75%
Maturity date					Aug. 15, 2015
No of convertible shares				147.0859
Principal amount per share | $ / shares				$ 1,000
Conversion price of shares | $ / shares				$ 6.80
Percentage of repurchase price				100.00%
Percentage of conversion price equaling stock price				150.00%
Number of trading days | d				20
Consecutive trading days				30 days
Long term note payable					$ 27,700
Senior convertible notes due August 15, 2015 | Issuance Of Common Stock In Exchange For 2015 Notes
Subsequent Event [Line Items]
Long term note payable					$ 8,000
Senior convertible notes due August 15, 2015 | Subsequent Event
Subsequent Event [Line Items]
Conversion price of shares | $ / shares	$ 4.40	$ 4.40
Long term note payable	$ 64,300	$ 64,300
Aggregate principal amount for conversion			$ 61,800
Number of shares issued up on conversion of debt | shares	1.9	1.9
Principal amount of debt converted	$ 8,000	$ 8,000

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