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Facility Agreement - Additional Information (Detail) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2015
Mar. 31, 2015
Sep. 30, 2014
Sep. 30, 2015
Sep. 30, 2014
Dec. 31, 2014
Jul. 01, 2013
Debt Instrument [Line Items]              
Short term liability $ 74,163,000     $ 74,163,000   $ 72,995,000  
Interest expense on notes 4,145,000   $ 5,424,000 $ 17,899,000 $ 11,895,000    
Deerfield              
Debt Instrument [Line Items]              
Principal repayment schedule, start date       Jul. 01, 2016      
Principal repayment schedule, end date       Dec. 09, 2019      
Deerfield | Milestone Rights Liability | Maximum              
Debt Instrument [Line Items]              
Contingent liability for milestone payments             $ 90,000,000
Deerfield | Senior convertible notes due December 31, 2019              
Debt Instrument [Line Items]              
Debt facility principal amount $ 60,000,000     $ 60,000,000      
Senior notes, effective interest rate 9.75%     9.75%      
Deerfield | Senior convertible notes due December 31, 2019 | Less portion of commitment asset              
Debt Instrument [Line Items]              
Debt facility principal amount $ 20,000,000     $ 20,000,000      
Senior notes, effective interest rate 8.75%     8.75%      
Deerfield | Senior convertible notes due December 31, 2019 | Less portion of commitment asset | Minimum | Facility Agreement              
Debt Instrument [Line Items]              
Available amount of credit facility under covenant restrictions $ 25,000,000     $ 25,000,000      
Deerfield | Senior convertible notes due December 31, 2019 | Milestone Rights Liability              
Debt Instrument [Line Items]              
Short term liability 1,600,000     1,600,000     3,200,000
Long term liability $ 8,900,000     $ 8,900,000     $ 13,100,000
Interest expense on notes   $ 5,800,000          
Required payment pursuant to the terms of the Milestone Agreement   $ 10,000,000