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Subsequent Events - Additional Information (Detail) - License and Collaboration Agreement with Sanofi - USD ($) $ in Millions				12 Months Ended
	Feb. 10, 2016	Jan. 04, 2016	Aug. 11, 2014	Dec. 31, 2015
Subsequent Event [Line Items]
Profits and losses sharing percentage			35.00%	35.00%
Sanofi-Aventis Deutschland GmbH
Subsequent Event [Line Items]
Profits and losses sharing percentage			65.00%	65.00%
Secured loan facility, amount borrowed				$ 44.5
Subsequent Event
Subsequent Event [Line Items]
Termination date		Jul. 04, 2016
Subsequent Event | Sanofi-Aventis Deutschland GmbH
Subsequent Event [Line Items]
Secured loan facility, amount borrowed	$ 17.9

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- Definition

Profit Loss Sharing Agreement Allocation Percentage

+ References

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- Definition

Termination Date Of License Agreement

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- Definition

The cash inflow from a long-term borrowing made from related parties where one party can exercise control or significant influence over another party; including affiliates, owners or officers and their immediate families, pension trusts, and so forth. Alternate caption: Proceeds from Advances from Affiliates.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 14
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3255-108585

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Financing Activities
-URI http://asc.fasb.org/extlink&oid=6513228

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- Definition

Detail information of subsequent event by type. User is expected to use existing line items from elsewhere in the taxonomy as the primary line items for this disclosure, which is further associated with dimension and member elements pertaining to a subsequent event.

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