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Facility Agreement - Additional Information (Detail) - USD ($)	3 Months Ended
	Mar. 31, 2016	Dec. 31, 2015	Jul. 01, 2013
Debt Instrument [Line Items]
Short term liability	$ 75,010,000	$ 74,582,000
Deerfield
Debt Instrument [Line Items]
Principal repayment schedule, start date	Jul. 01, 2016
Principal repayment schedule, end date	Dec. 09, 2019
Deerfield | Senior convertible notes due December 31, 2019
Debt Instrument [Line Items]
Debt facility principal amount	$ 60,000,000
Senior notes, effective interest rate	9.75%
Deerfield | Less portion of commitment asset | Senior convertible notes due December 31, 2019
Debt Instrument [Line Items]
Debt facility principal amount	$ 20,000,000
Senior notes, effective interest rate	8.75%
Deerfield | Less portion of commitment asset | Minimum | Senior convertible notes due December 31, 2019 | Facility Agreement
Debt Instrument [Line Items]
Available amount of credit facility under covenant restrictions	$ 25,000,000
Deerfield | Milestone Rights Liability | Senior convertible notes due December 31, 2019
Debt Instrument [Line Items]
Short term liability	8,900,000		$ 3,200,000
Long term liability	$ 8,900,000		13,100,000
Deerfield | Milestone Rights Liability | Maximum
Debt Instrument [Line Items]
Contingent liability for milestone payments			$ 90,000,000

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Contingent Liability

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Debt Instrument Date Of Last Required Payment

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- Definition

Date the debt agreement requires the first payment to be made, in CCYY-MM-DD format.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 470
-Section 50
-Paragraph 3
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=6479336&loc=d3e64711-112823

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.22)
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

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Face (par) amount of debt instrument at time of issuance.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 835
-SubTopic 30
-Section 55
-Paragraph 8
-URI http://asc.fasb.org/extlink&oid=34725769&loc=d3e28878-108400

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-URI http://asc.fasb.org/extlink&oid=6451184&loc=d3e28551-108399

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Contractual interest rate for funds borrowed, under the debt agreement.

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
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-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

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Carrying value as of the balance sheet date of the portion of long-term debt not otherwise specified in the taxonomy that is scheduled to be repaid within one year or the normal operating cycle, if longer.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
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-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 2: http://www.xbrl.org/2003/role/presentationRef
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-Name Regulation S-X (SX)
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Carrying value as of the balance sheet date of debt not otherwise defined (with maturities initially due after one year or beyond the operating cycle if longer), excluding current portion.

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