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Description of Business and Basis of Presentation - Additional Information (Detail) - USD ($)
3 Months Ended
Mar. 31, 2016
Dec. 31, 2015
Mar. 31, 2015
Dec. 31, 2014
Sep. 23, 2014
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]          
Accumulated deficit $ (2,888,102,000) $ (2,863,229,000)      
Cash and cash equivalents 27,653,000 $ 59,074,000 $ 120,844,000 $ 120,841,000  
Amount available for future borrowings $ 30,100,000        
License and Collaboration Agreement with Sanofi          
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]          
Profits and losses sharing percentage 35.00%        
Maximum secured loan facility         $ 175,000,000
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH          
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]          
Profits and losses sharing percentage 65.00%        
Maximum secured loan facility $ 175,000,000        
Senior convertible notes due December 31, 2019 | Deerfield | Minimum | Facility Agreement | Less portion of commitment asset          
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]          
Available amount of credit facility under covenant restrictions $ 25,000,000