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Fair Value of Financial Instruments - Additional Information (Detail) - USD ($) | 6 Months Ended |  |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Jun. 30, 2016 | May 31, 2016 | Dec. 31, 2015 | Jun. 30, 2015 | Dec. 31, 2014 | Sep. 23, 2014 | Jul. 01, 2013
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Cash and cash equivalents | $ 63,733,000 |  | $ 59,074,000 | $ 107,187,000 | $ 120,841,000 |  |
Cash equivalents, money market funds | 56,800,000 |  | 55,800,000 |  |  |  |
Fair value of Milestone Rights |  | $ 44,700,000 |  |  |  |  |
Carrying value | 27,623,000 |  | $ 27,613,000 |  |  |  |
License and Collaboration Agreement with Sanofi |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Maximum secured loan facility |  |  |  |  |  | $ 175,000,000 |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Maximum secured loan facility | 175,000,000 |  |  |  |  |  |
Carrying value | 70,300,000 |  |  |  |  |  |
Estimated fair value | 62,000,000 |  |  |  |  |  |
Milestone Rights Liability | Deerfield | Maximum |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Contingent liability for milestone payments |  |  |  |  |  |  | $ 90,000,000
Milestone Rights Liability | Senior convertible notes due December 31, 2019 | Deerfield |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Long term liability | 8,900,000 |  |  |  |  |  | $ 13,100,000
Fair Value, Inputs, Level 3 | Milestone Rights Liability |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Fair value of Milestone Rights | $ 15,600,000 |  |  |  |  |  |
Fair Value, Inputs, Level 3 | Market Approach Valuation Technique | 5.75% Senior convertible notes due August 15, 2018 | Convertible Debt Securities |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Fair value assumption, risk-free rate | 20.00% |  |  |  |  |  |
Fair value assumption, stock price volatility | 87.50% |  |  |  |  |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Sanofi-Aventis Deutschland GmbH |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Market discount rate | 11.00% |  |  |  |  |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Senior convertible notes due December 31, 2019 |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Market discount rate | 11.00% |  |  |  |  |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Less portion of commitment asset | Senior convertible notes due December 31, 2019 |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Market discount rate | 11.00% |  |  |  |  |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Milestone Rights Liability |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Market discount rate | 14.00% |  |  |  |  |  |

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- Definition Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Excludes cash and cash equivalents within disposal group and discontinued operation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Cash -URI http://asc.fasb.org/extlink&oid=6506951 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=28358313&loc=d3e6676-107765 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3044-108585 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Cash Equivalents -URI http://asc.fasb.org/extlink&oid=6507016 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.1) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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