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Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2016 | Jun. 30, 2015
CASH FLOWS FROM OPERATING ACTIVITIES: |  |
Net loss | $ (54,831) | $ (59,569)
Adjustments to reconcile net loss to net cash provided by (used) in operating activities: |  |
Depreciation and accretion | 2,058 | 6,359
Stock-based compensation expense | 2,628 | 3,778
Interest incurred through borrowings under Sanofi Loan Facility | 2,604 | 265
Loss on disposal of property and equipment |  | 12
Loss on foreign currency exchange | 2,023 |
Warrant fair value adjustment | 5,306 |
Warrant issuance cost | 653 |
Interest on note payable to principal stockholder | 1,443 | 1,435
Other, net | 717 | (6)
Changes in assets and liabilities: |  |
Inventory | (2,866) | (10,146)
Receivables from Collaboration | 23 | 45,688
Prepaid expenses and other current assets | 2,595 | 6,130
Deferred costs from collaboration |  | (10,831)
Other assets | (238) | (866)
Accounts payable | (12,532) | (2,236)
Accrued expenses and other current liabilities | 2,663 | (7,800)
Deferred sales from collaboration | 177 | 12,968
Deferred payment from collaboration | 9,202 |
Purchase commitment loss - current | 8,312 |
Non-current purchase commitment loss | (12,204) |
Other liabilities |  | 30
Net cash used in operating activities | (42,267) | (14,789)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |
Purchase of property and equipment | (1,144) | (8,737)
Proceeds from sale of property and equipment | 17 |
Net cash used in investing activities | (1,127) | (8,737)
CASH FLOWS FROM FINANCING ACTIVITIES: |  |
Proceeds from issuance of common stock | 734 | 12,820
Proceeds from direct placement | 50,000 |
Issuance costs associated with the direct placement | (2,678) |
Milestone payment |  | (4,220)
Other |  | 40
Proceeds from issuance of common stock pursuant to ATM issuance |  | 2,050
Payment of employment taxes related to vested restricted stock units | (3) | (818)
Net cash provided by financing activities | 48,053 | 9,872
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS | 4,659 | (13,654)
CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD | 59,074 | 120,841
CASH AND CASH EQUIVALENTS, END OF PERIOD | 63,733 | 107,187
SUPPLEMENTAL CASH FLOWS DISCLOSURES: |  |
Interest paid in cash, net of amounts capitalized | 4,608 | 6,644
Non-cash construction in progress and property and equipment |  | $ 623
Reclassification of deferred payments from collaboration to Sanofi Loan Facility and loss share obligation | 5,003 |
Reclassification of deferred costs from loss on purchase commitment to deferred costs from collaboration | $ 9,202 |

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- Definition Amount of income (expense) included in net income that results in no cash inflow (outflow), classified as other. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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- Definition Interest paid other than in cash for example by issuing additional debt securities. As a noncash item, it is added to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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- Definition The total of the cash outflow during the period which has been paid to third parties in connection with debt origination, which will be amortized over the remaining maturity period of the associated long-term debt and the cost incurred directly for the issuance of equity securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3291-108585 + Details
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- Definition Amount of cash outflow to satisfy an employee's income tax withholding obligation as part of a net-share settlement of a share-based award. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3291-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the amount received from entity's raising of capital via private rather than public placement. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 + Details
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- Definition Amount of cash inflow (outflow) from financing activities classified as other. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3095-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 9 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3098-108585 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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