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Description of Business and Basis of Presentation - Additional Information (Detail) - USD ($) |  | 1 Months Ended | 6 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | ---
Apr. 05, 2016 | May 31, 2016 | Jun. 30, 2016 | Jun. 30, 2015 | Dec. 31, 2015 | Dec. 31, 2014 | Sep. 23, 2014
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Accumulated deficit |  |  | $ (2,918,060,000) |  | $ (2,863,229,000) |  |
Number of shares sold in underwritten public offering |  | 48,543,692 |  |  |  |  |
Proceeds from offering of common stocks and warrants, net |  | $ 47,400,000 | 734,000 | $ 12,820,000 |  |  |
Cash and cash equivalents |  |  | 63,733,000 | $ 107,187,000 | $ 59,074,000 | $ 120,841,000 |
Amount available for future borrowings |  |  | $ 30,100,000 |  |  |  |
License and Collaboration Agreement with Sanofi |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Profits and losses sharing percentage | 35.00% |  | 35.00% |  |  |  |
Maximum secured loan facility |  |  |  |  |  |  | $ 175,000,000
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Profits and losses sharing percentage | 65.00% |  | 65.00% |  |  |  |
Maximum secured loan facility |  |  | $ 175,000,000 |  |  |  |
Maximum |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Number of warrants available for purchase common shares |  | 48,543,692 |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Minimum | Less portion of commitment asset |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Available amount of credit facility under covenant restrictions |  |  | $ 25,000,000 |  |  |  |

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