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Facility Agreement - Additional Information (Detail) - USD ($) | 9 Months Ended |  |
--- | --- | --- | ---
Sep. 30, 2016 | Dec. 31, 2015 | Jul. 01, 2013
Debt Instrument [Line Items] |  |  |
Debt facility principal amount | $ 27,690,000 | $ 27,690,000 |
Short term liability | $ 70,888,000 | $ 74,582,000 |
Deerfield |  |  |
Debt Instrument [Line Items] |  |  |
Principal repayment schedule, start date | Jul. 01, 2016 |  |
Principal repayment schedule, end date | Dec. 09, 2019 |  |
Deerfield | Senior convertible notes due December 31, 2019 |  |  |
Debt Instrument [Line Items] |  |  |
Debt facility principal amount | $ 55,000,000 |  |
Senior notes, effective interest rate | 9.75% |  |
Principal payments due during next twelve months | $ 20,000,000 |  |
Deerfield | Less portion of commitment asset | Senior convertible notes due December 31, 2019 |  |  |
Debt Instrument [Line Items] |  |  |
Debt facility principal amount | $ 20,000,000 |  |
Senior notes, effective interest rate | 8.75% |  |
Deerfield | Less portion of commitment asset | Minimum | Senior convertible notes due December 31, 2019 |  |  |
Debt Instrument [Line Items] |  |  |
Available amount of credit facility under covenant restrictions | $ 25,000,000 |  |
Deerfield | Milestone Rights Liability | Senior convertible notes due December 31, 2019 |  |  |
Debt Instrument [Line Items] |  |  |
Short term liability |  |  | $ 3,200,000
Long term liability | $ 8,900,000 |  | 13,100,000
Deerfield | Milestone Rights Liability | Maximum |  |  |
Debt Instrument [Line Items] |  |  |
Contingent liability for milestone payments |  |  | $ 90,000,000

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