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Fair Value of Financial Instruments - Additional Information (Detail) - USD ($) | 9 Months Ended |  |  |  |
--- | --- | --- | --- | --- | ---
Sep. 30, 2016 | May 31, 2016 | Dec. 31, 2015 | Sep. 23, 2014 | Jul. 01, 2013
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Cash equivalents, money market funds | $ 33,700,000 |  | $ 55,800,000 |  |
Debt facility principal amount | 27,690,000 |  | 27,690,000 |  |
Fair value of Milestone Rights |  | $ 44,700,000 |  |  |
Carrying value | 27,629,000 |  | $ 27,613,000 |  |
License and Collaboration Agreement with Sanofi |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Maximum secured loan facility |  |  |  | $ 175,000,000 |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Maximum secured loan facility | 175,000,000 |  |  |  |
Carrying value | 71,500,000 |  |  |  |
Estimated fair value | 61,800,000 |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Debt facility principal amount | 55,000,000 |  |  |  |
Less portion of commitment asset | Senior convertible notes due December 31, 2019 | Deerfield |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Debt facility principal amount | 20,000,000 |  |  |  |
Milestone Rights Liability | Deerfield | Maximum |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Contingent liability for milestone payments |  |  |  |  | $ 90,000,000
Milestone Rights Liability | Senior convertible notes due December 31, 2019 | Deerfield |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Long term liability | 8,900,000 |  |  |  | $ 13,100,000
Fair Value, Inputs, Level 3 | Milestone Rights Liability |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Fair value of Milestone Rights | $ 15,300,000 |  |  |  |
Fair Value, Inputs, Level 3 | Market Approach Valuation Technique | 5.75% Senior convertible notes due August 15, 2018 | Convertible Debt Securities |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Fair value assumption, risk-free rate | 20.00% |  |  |  |
Fair value assumption, stock price volatility | 90.00% |  |  |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Sanofi-Aventis Deutschland GmbH |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Market discount rate | 10.00% |  |  |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Senior convertible notes due December 31, 2019 |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Debt facility principal amount | $ 20,000,000 |  |  |  |
Market discount rate | 12.00% |  |  |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Less portion of commitment asset | Senior convertible notes due December 31, 2019 |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Debt facility principal amount | $ 40,000,000 |  |  |  |
Market discount rate | 11.00% |  |  |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Milestone Rights Liability |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Market discount rate | 13.50% |  |  |  |

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- Definition Amount, before unamortized (discount) premium and debt issuance costs, of long-term debt. Includes, but is not limited to, notes payable, bonds payable, commercial loans, mortgage loans, convertible debt, subordinated debt and other types of debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(22)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 944 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-03(16)) -URI http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.9-03(16)) -URI http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878 + Details
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- Definition Fair value portion of debt instrument payable, including, but not limited to, notes payable and loans payable. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 825 -SubTopic 10 -Section 50 -Paragraph 10 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=73719730&loc=d3e13433-108611 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 825 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=73719730&loc=d3e13476-108611 + Details
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- Definition Measure of dispersion, in percentage terms (for instance, the standard deviation or variance), for a given stock price. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bbb) -URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258 + Details
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- Definition Risk-free interest rate assumption used in valuing an instrument. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bbb) -URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258 + Details
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- Definition Interest rate used to find the present value of an amount to be paid or received in the future as an input to measure fair value. For example, but not limited to, weighted average cost of capital (WACC), cost of capital, cost of equity and cost of debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bbb) -URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258 + Details
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- Definition Fair value of financial and nonfinancial obligations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258 + Details
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