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Description of Business and Basis of Presentation - Additional Information (Detail) | 1 Months Ended | 3 Months Ended | 9 Months Ended |  |  |
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May 31, 2016 USD ($) shares | Sep. 30, 2016 USD ($) Payment | Sep. 30, 2016 USD ($) | Sep. 30, 2015 USD ($) | Dec. 31, 2015 USD ($) | Dec. 31, 2014 USD ($) | Sep. 23, 2014 USD ($)
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Accumulated deficit |  | $ (2,791,540,000) | $ (2,791,540,000) |  | $ (2,863,229,000) |  |
Number of shares sold in a registered public offering | shares | 48,543,692 |  |  |  |  |  |
Proceeds from offering of common stocks and warrants, net | $ 47,400,000 |  | 772,000 | $ 13,524,000 |  |  |
Cash and cash equivalents |  | 35,530,000 | 35,530,000 | $ 32,928,000 | 59,074,000 | $ 120,841,000 |
Amount available for future borrowings |  | 30,100,000 | 30,100,000 |  |  |  |
Net revenue from collaboration |  | 161,781,000 | 161,781,000 |  |  |  |
Net revenue - commercial product sales |  | 573,000 | 573,000 |  |  |  |
Deferred revenue |  | $ 2,014,000 | $ 2,014,000 |  |  |  |
Cash discount as incentive for prompt payment |  | 2.00% | 2.00% |  |  |  |
Third party logistics |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Deferred revenue |  | $ 1,600,000 | $ 1,600,000 |  |  |  |
Third Party |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Deferred revenue |  | 400,000 | $ 400,000 |  |  |  |
License and Collaboration Agreement with Sanofi |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Profits and losses sharing percentage |  |  | 35.00% |  |  |  |
Maximum secured loan facility |  |  |  |  |  |  | $ 175,000,000
Net revenue from collaboration |  | 161,800,000 | $ 161,800,000 |  |  |  |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Profits and losses sharing percentage |  |  | 65.00% |  |  |  |
Maximum secured loan facility |  | 175,000,000 | $ 175,000,000 |  |  |  |
Deferred sales from collaboration product shipments |  | 150,000,000 | 150,000,000 |  |  |  |
Milestone receivable |  | 25,000,000 | 25,000,000 |  |  |  |
Deferred cost |  |  |  |  | 13,500,000 |  |
Net revenue from collaboration |  | 17,400,000 |  |  |  |  |
Up-front fee |  | $ 150,000,000 |  |  |  |  |
Number of milestone payment | Payment |  | 2 |  |  |  |  |
Milestone payments earned |  | $ 25,000,000 | $ 25,000,000 |  |  |  |
Net loss share payments |  | (64,800,000) |  |  |  |  |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH | Insulin Put |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Net revenue from collaboration |  | 9,200,000 |  |  |  |  |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH | AFREZZA product sales |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Deferred sales from collaboration product shipments |  |  |  |  | $ 17,500,000 |  |
Maximum |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Number of warrants available for purchase common shares | shares | 48,543,692 |  |  |  |  |  |
Maximum | AFREZZA product sales |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Sales return right following product expiration in months |  |  | 12 months |  |  |  |
Minimum | AFREZZA product sales |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Sales return right following product expiration in months |  |  | 6 months |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Minimum | Less portion of commitment asset |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Available amount of credit facility under covenant restrictions |  | $ 25,000,000 | $ 25,000,000 |  |  |  |

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