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Fair Value of Financial Instruments (Detail) - USD ($)
$ in Millions
Sep. 30, 2016
Dec. 31, 2015
Financial liabilities:    
Financial liabilities fair value $ 178.6 $ 150.6
Sanofi-Aventis Deutschland GmbH    
Financial liabilities:    
Financial liabilities fair value 61.8 36.5
Warrant Liability    
Financial liabilities:    
Financial liabilities fair value 4.9  
Milestone Rights Liability    
Financial liabilities:    
Financial liabilities fair value 15.3 14.4
Senior Convertible Notes | Convertible Debt Securities    
Financial liabilities:    
Financial liabilities fair value 21.7 21.3
Facility financing obligation    
Financial liabilities:    
Financial liabilities fair value 74.9 78.4
Fair Value, Inputs, Level 3    
Financial liabilities:    
Financial liabilities fair value 178.6 150.6
Fair Value, Inputs, Level 3 | Sanofi-Aventis Deutschland GmbH    
Financial liabilities:    
Financial liabilities fair value 61.8 36.5
Fair Value, Inputs, Level 3 | Warrant Liability    
Financial liabilities:    
Financial liabilities fair value 4.9  
Fair Value, Inputs, Level 3 | Milestone Rights Liability    
Financial liabilities:    
Financial liabilities fair value 15.3 14.4
Fair Value, Inputs, Level 3 | Senior Convertible Notes | Convertible Debt Securities    
Financial liabilities:    
Financial liabilities fair value 21.7 21.3
Fair Value, Inputs, Level 3 | Facility financing obligation    
Financial liabilities:    
Financial liabilities fair value $ 74.9 $ 78.4