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Fair Value of Financial Instruments - Additional Information (Detail) - USD ($) |  | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | ---
Dec. 31, 2013 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014 | May 31, 2016 | Sep. 23, 2014 | Jul. 01, 2013
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Cash equivalents, money market funds |  | $ 20,500,000 | $ 55,800,000 |  |  |  |
Fair value of Milestone Rights |  |  |  |  | $ 44,700,000 |  |
Property and equipment, net |  | 28,927,000 | 48,749,000 |  |  |  |
Property and equipment impairment |  | 1,259,000 | 140,412,000 | $ 0 |  |  |
Gain (loss) on property, plant and equipment |  | $ (600,000) |  |  |  |  |
Carrying Value |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Property and equipment, net |  |  | 189,200,000 |  |  |  |
Sanofi-Aventis Deutschland GmbH |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Loan facility forgiven date |  | Nov. 09, 2016 |  |  |  |  |
License and Collaboration Agreement with Sanofi |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Maximum secured loan facility |  |  |  |  |  | $ 175,000,000 |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Maximum secured loan facility |  | $ 175,000,000 |  |  |  |  |
Milestone Rights Liability | Deerfield |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Long term liability |  | 8,900,000 |  |  |  |  |
Milestone Rights Liability | Deerfield | Maximum |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Contingent liability for milestone payments |  |  |  |  |  |  | $ 90,000,000
Milestone Rights Liability | Senior convertible notes due December 31, 2019 | Deerfield |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Market discount rate | 14.50% |  |  |  |  |  |
Long term liability |  | 8,900,000 | 8,900,000 |  |  |  | $ 13,100,000
Fair Value, Inputs, Level 3 |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Property, plant, and equipment, fair value |  |  | 48,800,000 |  |  |  |
Property and equipment impairment |  | 700,000 | $ (140,412,000) |  |  |  |
Fair Value, Inputs, Level 3 | Milestone Rights Liability |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Fair value of Milestone Rights |  | $ 18,400,000 |  |  |  |  |
Fair Value, Inputs, Level 3 | Market Approach Valuation Technique | 5.75% Senior convertible notes due August 15, 2018 | Convertible Debt Securities |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Fair value assumption, risk-free rate |  | 20.00% |  |  |  |  |
Fair value assumption, stock price volatility |  | 111.00% |  |  |  |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Sanofi-Aventis Deutschland GmbH |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Market discount rate |  | 11.00% |  |  |  |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Senior convertible notes due December 31, 2019 |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Market discount rate |  | 12.00% |  |  |  |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Milestone Rights Liability |  |  |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |  |  |
Market discount rate |  | 14.50% |  |  |  |  |

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- Definition Measure of dispersion, in percentage terms (for instance, the standard deviation or variance), for a given stock price. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bbb) -URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258 + Details
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- Definition Interest rate used to find the present value of an amount to be paid or received in the future as an input to measure fair value. For example, but not limited to, weighted average cost of capital (WACC), cost of capital, cost of equity and cost of debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bbb) -URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258 + Details
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