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Components of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2016 | Dec. 31, 2015
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 712,124 | $ 721,588
Research and development credits | 77,998 | 73,646
Capitalized research | 5,117 | 5,872
Payments from collaboration |  | 52,484
Milestone Rights | 3,242 | 3,242
Accrued expenses | 440 | 251
Loss on purchase commitment | 36,775 | 24,084
Non-qualified stock option expense | 17,331 | 16,941
Capitalized patent costs | 8,781 | 8,574
Other | 7,380 | 7,186
Depreciation | 45,310 | 48,755
Total net deferred tax assets | 914,498 | 962,623
Valuation allowance | (914,498) | (962,623)
Net deferred tax assets | $ 0 | $ 0

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