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Description of Business - Additional Information (Detail) - USD ($) |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Nov. 09, 2016 | Jan. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Net revenue from collaboration |  |  |  |  | $ 171,965,000 |  |  |
Gain on extinguishment of debt |  |  |  |  | 72,024,000 | $ (1,049,000) |  |
Accumulated deficit |  |  | $ (2,737,565,000) |  | (2,737,565,000) | (2,863,229,000) |  |
Cash and cash equivalents |  |  | 22,895,000 |  | 22,895,000 | 59,074,000 | $ 120,841,000 | $ 70,790,000
Loan Arrangement |  |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Amount available for future borrowings |  |  | 30,100,000 |  | 30,100,000 | $ 30,100,000 |  |
License and Collaboration Agreement with Sanofi |  |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Gain on extinguishment of debt | $ 500,000 |  |  |  |  |  |  |
Insulin Put |  |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Net revenue from collaboration |  |  |  |  | 10,200,000 |  |  |
Principal stockholder | Loan Arrangement |  |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Amount available for future borrowings |  |  | 30,100,000 |  | 30,100,000 |  |  |
Aventisub LLC |  |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Outstanding loan balance forgive | $ 72,000,000 |  |  |  |  |  |  |
Sanofi-Aventis Deutschland GmbH | License and Collaboration Agreement with Sanofi |  |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Net revenue from collaboration |  |  | 10,200,000 | $ 161,800,000 | 172,000,000 |  |  |
Gain on extinguishment of debt |  |  | 72,000,000 |  |  |  |  |
Up-front fee |  |  |  |  | 150,000,000 |  |  |
Sanofi-Aventis Deutschland GmbH | Insulin Put | License and Collaboration Agreement with Sanofi |  |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Net revenue from collaboration |  |  |  |  | 19,400,000 |  |  |
Sanofi-Aventis Deutschland GmbH | Subsequent Event | Put Option |  |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Payment for insulin put option |  | $ 30,600,000 |  |  |  |  |  |
Deerfield | Senior convertible notes due December 31, 2019 | Minimum | Less portion of commitment asset |  |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Available amount of credit facility under covenant restrictions |  |  | $ 25,000,000 |  | $ 25,000,000 |  |  |

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