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Selected Quarterly Financial Data - Additional Information (Detail) - USD ($) $ in Thousands |  | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Nov. 09, 2016 | Dec. 31, 2016 | Sep. 30, 2016 | Dec. 31, 2015 | Dec. 31, 2016 | Dec. 31, 2015
Interim Reporting [Line Items] |  |  |  |  |  |
Asset impairment charges |  |  |  | $ 242,700 |  |
Net revenue from collaboration |  |  |  |  | $ 171,965 |
Gain (loss) on extinguishment of debt |  |  |  |  | 72,024 | $ (1,049)
License and Collaboration Agreement with Sanofi |  |  |  |  |  |
Interim Reporting [Line Items] |  |  |  |  |  |
Gain (loss) on extinguishment of debt | $ 500 |  |  |  |  |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH |  |  |  |  |  |
Interim Reporting [Line Items] |  |  |  |  |  |
Net revenue from collaboration |  | $ 10,200 | $ 161,800 |  | $ 172,000 |
Gain (loss) on extinguishment of debt |  | $ 72,000 |  |  |  |

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