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Borrowings - Additional Information (Detail) |  |  |  |  |  | 3 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Sep. 30, 2015 USD ($) | Aug. 17, 2015 USD ($) | Aug. 10, 2015 USD ($) $ / shares shares | Aug. 10, 2015 USD ($) d $ / shares | Jul. 28, 2015 USD ($) | Dec. 31, 2013 USD ($) | Mar. 31, 2015 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($) | Dec. 31, 2014 USD ($) shares | Aug. 14, 2015 USD ($) | Jul. 01, 2013 USD ($) | Aug. 18, 2010 USD ($)
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Facility Agreement, total principle payment in 2017 |  |  |  |  |  |  |  | $ 20,000,000 |  |  |  |  |
Facility Agreement, total principle payment in 2018 |  |  |  |  |  |  |  | 20,000,000 |  |  |  |  |
Facility Agreement, total principle payment in 2019 |  |  |  |  |  |  |  | 35,000,000 |  |  |  |  |
Interest expense on notes |  |  |  |  |  |  |  | 15,576,000 | $ 21,231,000 | $ 17,549,000 |  |  |
Aggregate principal amount for conversion |  |  |  |  |  |  |  |  |  | 93,500,000 |  |  |
Payments on senior notes |  |  |  |  |  |  |  |  | 64,287,000 |  |  |  |
Loss on extinguishment of debt |  |  |  |  |  |  |  | 72,024,000 | (1,049,000) |  |  |  |
2018 Notes |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Accretion of debt issuance costs |  |  |  |  |  |  |  | $ 257,000 | 93,000 |  |  |  |
2015 Notes |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Accretion of debt issuance costs |  |  |  |  |  |  |  |  | 600,000 | 900,000 |  |  |
Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Principal repayment schedule, start date |  |  |  |  |  |  |  | Jul. 01, 2016 |  |  |  |  |
Principal repayment schedule, end date |  |  |  |  |  |  |  | Dec. 09, 2019 |  |  |  |  |
Aggregate principal amount for conversion |  |  |  |  |  |  |  |  |  | $ 93,500,000 |  |  |
Conversion Option, shares | shares |  |  |  |  |  |  |  |  |  | 3,464,616 |  |  |
Conversion Option, aggregate expense |  |  |  |  |  |  |  |  |  | $ 6,400,000 |  |  |
Premium of issuance of 2018 debt |  |  |  |  |  |  |  | $ 1,722,000 | 1,553,000 | 7,550,000 |  |  |
Deerfield | Milestone Rights Liability |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Long term liability |  |  |  |  |  |  |  | 8,900,000 |  |  |  |  |
Deerfield | Milestone Rights Liability | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent liability for milestone payments |  |  |  |  |  |  |  |  |  |  |  | $ 90,000,000 |
Deerfield | Tranche 1 note |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount for conversion |  |  |  |  |  |  |  |  |  | 20,000,000 |  |  |
Conversion Option, aggregate expense |  |  |  |  |  |  |  |  |  | 1,200,000 |  |  |
Deerfield | Tranche 2 note |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount for conversion |  |  |  |  |  |  |  |  |  | 33,500,000 |  |  |
Conversion Option, aggregate expense |  |  |  |  |  |  |  |  |  | 3,000,000 |  |  |
Deerfield | Tranche 3 note |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount for conversion |  |  |  |  |  |  |  |  |  | 40,000,000 |  |  |
Conversion Option, aggregate expense |  |  |  |  |  |  |  |  |  | 2,200,000 |  |  |
5.75% Senior convertible notes due August 15, 2018 |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Debt facility principal amount |  |  | $ 27,700,000 | $ 27,700,000 |  |  |  | 27,690,000 | 27,690,000 |  |  |  |
Senior notes, effective interest rate |  |  | 5.75% | 5.75% |  |  |  |  |  |  |  |  |
Unamortized debt issuance cost |  |  |  |  |  |  |  | 481,000 | 737,000 |  |  |  |
Carrying value |  |  |  |  |  |  |  | 27,635,000 | 27,613,000 |  |  |  |
Unamortized premium |  |  | $ 700,000 | $ 700,000 |  |  |  | $ 426,000 | 660,000 |  |  |  |
Maturity date |  |  |  |  |  |  |  | Aug. 15, 2018 |  |  |  |  |
No of convertible shares |  |  |  | 29 |  |  |  |  |  |  |  |  |
Principal amount per share | $ / shares |  |  |  | $ 1,000 |  |  |  |  |  |  |  |  |
Conversion price of shares | $ / shares |  |  | $ 34.00 | $ 34.00 |  |  |  |  |  |  |  |  |
Percentage of repurchase price |  |  |  | 100.00% |  |  |  |  |  |  |  |  |
Debt Instrument, redemption description |  |  |  |  |  |  |  | On or after the date that is one year following the original issue date of the 2018 notes, the Company will have the right to redeem for cash all or part of the 2018 notes if the last reported sale price of its common stock exceeds 130% of the conversion price then in effect for 20 or more trading days during the 30 consecutive trading day period ending on the trading day immediately prior to the date of the redemption notice. The redemption price will equal the sum of 100% of the principal amount of the 2018 notes to be redeemed, plus accrued and unpaid interest. |  |  |  |  |
Percentage of conversion price equaling stock price |  |  |  | 130.00% |  |  |  |  |  |  |  |  |
Number of trading days | d |  |  |  | 20 |  |  |  |  |  |  |  |  |
Consecutive trading days |  |  |  | 30 days |  |  |  |  |  |  |  |  |
Debt Issuance Cost |  |  |  |  |  |  |  |  |  |  |  |  | $ 800,000
Premium of issuance of 2018 debt |  |  |  |  |  |  |  | $ 234,000 | 86,000 |  |  |  |
Senior convertible notes due August 15, 2015 |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Debt facility principal amount |  |  |  |  |  |  |  |  |  | 100,000,000 | $ 32,100,000 |  |
Senior notes, effective interest rate |  |  |  |  |  |  |  |  |  |  | 5.75% |  |
Aggregate principal amount for conversion |  |  |  |  | $ 56,900,000 |  |  |  |  |  |  |  |
Conversion Option, shares | shares |  |  | 380,000 |  |  |  |  |  |  |  |  |  |
Conversion price of shares | $ / shares |  |  | $ 110.00 | $ 110.00 |  |  |  |  |  |  |  |  |
Principal amount of debt converted |  |  | $ 8,000,000 |  |  |  |  |  |  |  |  |  |
Payments on senior notes | $ 32,100,000 | $ 32,200,000 |  |  |  |  |  |  |  |  |  |  |
Loss on extinguishment of debt |  | $ 1,000,000 |  |  |  |  |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Debt facility principal amount |  |  |  |  |  |  |  | 75,000,000 | 80,000,000 |  |  |  |
Unamortized debt discount |  |  |  |  |  |  |  | 3,661,000 | 5,418,000 |  |  |  |
Carrying value |  |  |  |  |  |  |  | 71,339,000 | 74,582,000 |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Debt facility principal amount |  |  |  |  |  |  |  | $ 55,000,000 | 60,000,000 |  |  |  |
Senior notes, effective interest rate |  |  |  |  |  |  |  | 9.75% |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Facility Agreement |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Unamortized debt discount |  |  |  |  |  |  |  | $ 3,700,000 |  |  |  |  |
Unamortized debt issuance cost |  |  |  |  |  |  |  | 100,000 |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Milestone Rights Liability |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Short term liability |  |  |  |  |  |  |  |  |  |  |  | 3,200,000 |
Long term liability |  |  |  |  |  |  |  | 8,900,000 | 8,900,000 |  |  | $ 13,100,000 |
Interest expense on notes |  |  |  |  |  |  | $ 5,800,000 |  |  |  |  |  |
Required payment pursuant to the terms of the Milestone Agreement |  |  |  |  |  |  | $ 10,000,000 |  |  |  |  |  |
Discount rate |  |  |  |  |  | 14.50% |  |  |  |  |  |  |
Risk premium |  |  |  |  |  | 5.00% |  |  |  |  |  |  |
Fair value of milestone rights |  |  |  |  |  | $ 18,400,000 |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Milestone Rights Liability | Danbury Facility |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Carrying value |  |  |  |  |  |  |  | 28,700,000 |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Debt facility principal amount |  |  |  |  |  |  |  | $ 20,000,000 | $ 20,000,000 |  |  |  |
Senior notes, effective interest rate |  |  |  |  |  |  |  | 8.75% |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Available amount of credit facility under covenant restrictions |  |  |  |  |  |  |  | $ 25,000,000 |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset | Minimum | Facility Agreement |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Available amount of credit facility under covenant restrictions |  |  |  |  |  |  |  | $ 25,000,000 |  |  |  |  |
Senior convertible notes due December 31, 2019 | Sanofi-Aventis Deutschland GmbH | Milestone Rights Liability |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense on notes |  |  |  |  |  |  |  |  |  | 1,900,000 |  |  |
Required payment pursuant to the terms of the Milestone Agreement |  |  |  |  |  |  |  |  |  | $ 5,000,000 |  |  |

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- Definition Amount of noncash expense included in interest expense to amortize debt discount and premium associated with the related debt instruments. Excludes amortization of financing costs. Alternate captions include noncash interest expense. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 835 -SubTopic 30 -Section 45 -Paragraph 1A -URI http://asc.fasb.org/extlink&oid=64930785&loc=d3e28541-108399 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.8) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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- Definition The value of the stock converted in a noncash (or part noncash) transaction. Noncash is defined as transactions during a period that do not result in cash receipts or cash payments in the period. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4313-108586 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4332-108586 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4304-108586 + Details
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- Definition The value of the financial instrument(s) that the original debt is being converted into in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4304-108586 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4332-108586 + Details
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- Definition The number of shares issued in exchange for the original debt being converted in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or payments in the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4332-108586 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4304-108586 + Details
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- Definition The amount of the original debt being converted in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4304-108586 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4332-108586 + Details
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- Definition Amount, before unamortized (discount) premium and debt issuance costs, of long-term debt. Includes, but is not limited to, notes payable, bonds payable, commercial loans, mortgage loans, convertible debt, subordinated debt and other types of debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(22)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 944 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-03(16)) -URI http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.9-03(16)) -URI http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878 + Details
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