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Statements of Stockholders' (Deficit) - USD ($) $ in Thousands | Total | TEL AVIV STOCK EXCHANGE | Common Stock | Common Stock TEL AVIV STOCK EXCHANGE | Additional Paid-in Capital | Additional Paid-in Capital TEL AVIV STOCK EXCHANGE | Accumulated Other Comprehensive Income (Loss) | Deficit Accumulated During the Development Stage
--- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning Balance (in shares) at Dec. 31, 2013 |  |  | 73,878,000 |  |  |  |  |
Beginning Balance at Dec. 31, 2013 | $ (30,713) |  | $ 3,697 |  | $ 2,261,996 |  | $ (4) | $ (2,296,402)
Exercise of stock options (in shares) |  |  | 650,000 |  |  |  |  |
Exercise of stock options | 10,978 |  | $ 35 |  | 10,943 |  |  |
Issuance of common shares from the release of restricted stock units (in shares) |  |  | 799,000 |  |  |  |  |
Issuance of common shares from the release of restricted stock units | (26,908) |  | $ 38 |  | (26,946) |  |  |
Issuance of common shares pursuant to warrant exercises (in shares) |  |  | 2,315,000 |  |  |  |  |
Issuance of common shares pursuant to warrant exercises | $ 27,779 |  | $ 115 |  | 27,664 |  |  |
Issuance of common shares under Employee Stock Purchase Plan (in shares) | 61,015 |  | 65,000 |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | $ 1,363 |  | $ 2 |  | 1,361 |  |  |
Stock-based compensation expense | 25,660 |  |  |  | 25,660 |  |  |
Issuance of common shares pursuant to debt conversions by Deerfield (in Shares) |  |  | 3,505,000 |  |  |  |  |
Issuance of common shares pursuant to debt conversions by Deerfield | 93,501 |  | $ 174 |  | 93,327 |  |  |
Remeasurement of performance based grants pursuant to the modification of terms | $ 22,962 |  |  |  | 22,962 |  |  |
Return of loaned common stock (in shares) | (1,800,000) |  |  |  |  |  |  |
Unrealized gain/(loss) on foreign currency translation | $ (10) |  |  |  |  |  | (10) |
Net income (loss) | (198,382) |  |  |  |  |  |  | (198,382)
Ending Balance (in shares) at Dec. 31, 2014 |  |  | 81,212,000 |  |  |  |  |
Ending Balance at Dec. 31, 2014 | (73,770) |  | $ 4,061 |  | 2,416,967 |  | (14) | (2,494,784)
Exercise of stock options (in shares) |  |  | 340,000 |  |  |  |  |
Exercise of stock options | 3,258 |  | $ 17 |  | 3,241 |  |  |
Issuance of common shares from the release of restricted stock units (in shares) |  |  | 144,000 |  |  |  |  |
Issuance of common shares from the release of restricted stock units |  |  | $ 7 |  | (7) |  |  |
Issuance of common shares pursuant to warrant exercises (in shares) |  |  | 843,000 |  |  |  |  |
Issuance of common shares pursuant to warrant exercises | $ 10,123 |  | $ 42 |  | 10,081 |  |  |
Issuance of common shares under Employee Stock Purchase Plan (in shares) | 64,245 |  | 54,000 |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | $ 887 |  | $ 3 |  | 884 |  |  |
Stock-based compensation expense | 8,725 |  |  |  | 8,725 |  |  |
Restricted stock units taxes paid in cash | (1,856) |  |  |  | (1,856) |  |  |
Capital contribution | 40 |  |  |  | 40 |  |  |
Issuance of common shares pursuant to conversions of certain 2015 note holders (in shares) |  |  | 375,000 |  |  |  |  |
Issuance of common shares pursuant to conversions of certain 2015 notes | 7,926 |  | $ 19 |  | 7,907 |  |  |
Issuance of common stock for lender financing fees (in shares) |  |  | 8,000 |  |  |  |  |
Issuance of common stock for lender financing fees | 160 |  |  |  | 160 |  |  |
Discount on notes-for-stock exchange | 169 |  |  |  | 169 |  |  |
Return of loaned common stock (in shares) |  |  | (1,800,000) |  |  |  |  |
Return of loaned common stock |  |  | $ (90) |  | 90 |  |  |
Issuance of common stock | 27,843 | $ 34,710 | $ 89 | $ 139 | 27,754 | $ 34,571 |  |
Issuance of common stock (Shares) |  |  | 1,788,000 | 2,771,000 |  |  |  |
Issuance of warrant liability | (202) |  |  |  | (202) |  |  |
Reclassification of warrant liability to equity | 109 |  |  |  | 109 |  |  |
Unrealized gain/(loss) on foreign currency translation | (6) |  |  |  |  |  | (6) |
Net income (loss) | (368,445) |  |  |  |  |  |  | (368,445)
Ending Balance (in shares) at Dec. 31, 2015 |  |  | 85,735,000 |  |  |  |  |
Ending Balance at Dec. 31, 2015 | $ (350,329) |  | $ 4,287 |  | 2,508,633 |  | (20) | (2,863,229)
Exercise of stock options (in shares) | 55,231 |  | 55,000 |  |  |  |  |
Exercise of stock options | $ 467 |  | $ 3 |  | 464 |  |  |
Issuance of common shares from the release of restricted stock units (in shares) |  |  | 131,000 |  |  |  |  |
Issuance of common shares from the release of restricted stock units |  |  | $ 7 |  | (7) |  |  |
Issuance of common shares under Employee Stock Purchase Plan (in shares) | 104,758 |  | 51,000 |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | $ 426 |  | $ 2 |  | 424 |  |  |
Stock-based compensation expense | 5,135 |  |  |  | 5,135 |  |  |
Restricted stock units taxes paid in cash | (165) |  |  |  | (165) |  |  |
Issuance of direct placement - common stock and warrants (value) | 50,000 |  | $ 485 |  | 49,515 |  |  |
Issuance of direct placement - common stock and warrants (shares) |  |  | 9,709,000 |  |  |  |  |
Issuance costs associated with direct placement | (2,037) |  |  |  | (2,037) |  |  |
Issuance of warrant liability | (12,750) |  |  |  | (12,750) |  |  |
Unrealized gain/(loss) on foreign currency translation | (4) |  |  |  |  |  | (4) |
Net income (loss) | 125,664 |  |  |  |  |  |  | 125,664
Ending Balance (in shares) at Dec. 31, 2016 |  |  | 95,681,000 |  |  |  |  |
Ending Balance at Dec. 31, 2016 | $ (183,593) |  | $ 4,784 |  | $ 2,549,212 |  | $ (24) | $ (2,737,565)

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