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Income Taxes -Additional Information (Detail) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Aug. 31, 2004 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Income Taxes [Line Items] |  |  |  |
Amount Equity would be increased |  | $ 11,600 |  |
Change in the valuation allowance |  | (48,100) | $ 80,100 | $ 65,500
Federal operating loss carryforwards |  | 1,900,000 |  |
State operating loss carryforwards |  | 1,300,000 |  |
Net operating loss carryforwards | $ 216,000 |  |  |
Net operating loss and credit carryforwards, annual use limitation | $ 13,000 |  |  |
Research and development credits |  | $ 77,998 | $ 73,646 |
Federal |  |  |  |
Income Taxes [Line Items] |  |  |  |
Net operating loss carryforwards, expiration year |  | 2018 |  |
Research and development credits |  | $ 53,000 |  |
Federal research and development credits begin to expire |  | 2024 |  |
State |  |  |  |
Income Taxes [Line Items] |  |  |  |
Research and development credits |  | $ 38,500 |  |

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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible domestic operating loss carryforwards. Excludes state and local operating loss carryforwards. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32621-109319 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 25 -Paragraph 20 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=68052875&loc=d3e28680-109314 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32632-109319 + Details
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