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Borrowings - Additional Information (Detail)
3 Months Ended 12 Months Ended
Sep. 30, 2015
USD ($)
Aug. 17, 2015
USD ($)
Aug. 10, 2015
USD ($)
$ / shares
shares
Aug. 10, 2015
USD ($)
d
$ / shares
Jul. 28, 2015
USD ($)
Dec. 31, 2013
USD ($)
Mar. 31, 2015
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
shares
Aug. 14, 2015
USD ($)
Jul. 01, 2013
USD ($)
Aug. 18, 2010
USD ($)
Debt Instrument [Line Items]                          
Facility Agreement, total principle payment in 2017               $ 20,000,000          
Facility Agreement, total principle payment in 2018               20,000,000          
Facility Agreement, total principle payment in 2019               35,000,000          
Interest expense on notes               15,576,000 $ 21,231,000 $ 17,549,000      
Aggregate principal amount for conversion                   93,500,000      
Payments on senior notes                 64,287,000        
Loss on extinguishment of debt               72,024,000 (1,049,000)        
2018 Notes                          
Debt Instrument [Line Items]                          
Accretion of debt issuance costs               $ 257,000 93,000        
2015 Notes                          
Debt Instrument [Line Items]                          
Accretion of debt issuance costs                 600,000 900,000      
Deerfield                          
Debt Instrument [Line Items]                          
Principal repayment schedule, start date               Jul. 01, 2016          
Principal repayment schedule, end date               Dec. 09, 2019          
Aggregate principal amount for conversion                   $ 93,500,000      
Conversion Option, shares | shares                   3,464,616      
Conversion Option, aggregate expense                   $ 6,400,000      
Premium of issuance of 2018 debt               $ 1,722,000 1,553,000 7,550,000      
Deerfield | Milestone Rights Liability                          
Debt Instrument [Line Items]                          
Long term liability               8,900,000          
Deerfield | Milestone Rights Liability | Maximum                          
Debt Instrument [Line Items]                          
Contingent liability for milestone payments                       $ 90,000,000  
Deerfield | Tranche 1 note                          
Debt Instrument [Line Items]                          
Aggregate principal amount for conversion                   20,000,000      
Conversion Option, aggregate expense                   1,200,000      
Deerfield | Tranche 2 note                          
Debt Instrument [Line Items]                          
Aggregate principal amount for conversion                   33,500,000      
Conversion Option, aggregate expense                   3,000,000      
Deerfield | Tranche 3 note                          
Debt Instrument [Line Items]                          
Aggregate principal amount for conversion                   40,000,000      
Conversion Option, aggregate expense                   2,200,000      
5.75% Senior convertible notes due August 15, 2018                          
Debt Instrument [Line Items]                          
Debt facility principal amount     $ 27,700,000 $ 27,700,000       27,690,000 27,690,000        
Senior notes, effective interest rate     5.75% 5.75%                  
Unamortized debt issuance cost               481,000 737,000        
Carrying value               27,635,000 27,613,000        
Unamortized premium     $ 700,000 $ 700,000       $ 426,000 660,000        
Maturity date               Aug. 15, 2018          
No of convertible shares       29                  
Principal amount per share | $ / shares       $ 1,000                  
Conversion price of shares | $ / shares     $ 34.00 $ 34.00                  
Percentage of repurchase price       100.00%                  
Debt Instrument, redemption description               On or after the date that is one year following the original issue date of the 2018 notes, the Company will have the right to redeem for cash all or part of the 2018 notes if the last reported sale price of its common stock exceeds 130% of the conversion price then in effect for 20 or more trading days during the 30 consecutive trading day period ending on the trading day immediately prior to the date of the redemption notice. The redemption price will equal the sum of 100% of the principal amount of the 2018 notes to be redeemed, plus accrued and unpaid interest.          
Percentage of conversion price equaling stock price       130.00%                  
Number of trading days | d       20                  
Consecutive trading days       30 days                  
Debt Issuance Cost                         $ 800,000
Premium of issuance of 2018 debt               $ 234,000 86,000        
Senior convertible notes due August 15, 2015                          
Debt Instrument [Line Items]                          
Debt facility principal amount                   100,000,000 $ 32,100,000    
Senior notes, effective interest rate                     5.75%    
Aggregate principal amount for conversion         $ 56,900,000                
Conversion Option, shares | shares     380,000                    
Conversion price of shares | $ / shares     $ 110.00 $ 110.00                  
Principal amount of debt converted     $ 8,000,000                    
Payments on senior notes $ 32,100,000 $ 32,200,000                      
Loss on extinguishment of debt   $ 1,000,000                      
Senior convertible notes due December 31, 2019                          
Debt Instrument [Line Items]                          
Debt facility principal amount               75,000,000 80,000,000        
Unamortized debt discount               3,661,000 5,418,000        
Carrying value               71,339,000 74,582,000        
Senior convertible notes due December 31, 2019 | Deerfield                          
Debt Instrument [Line Items]                          
Debt facility principal amount               $ 55,000,000 60,000,000        
Senior notes, effective interest rate               9.75%          
Senior convertible notes due December 31, 2019 | Deerfield | Facility Agreement                          
Debt Instrument [Line Items]                          
Unamortized debt discount               $ 3,700,000          
Unamortized debt issuance cost               100,000          
Senior convertible notes due December 31, 2019 | Deerfield | Milestone Rights Liability                          
Debt Instrument [Line Items]                          
Short term liability                       3,200,000  
Long term liability               8,900,000 8,900,000     $ 13,100,000  
Interest expense on notes             $ 5,800,000            
Required payment pursuant to the terms of the Milestone Agreement             $ 10,000,000            
Discount rate           14.50%              
Risk premium           5.00%              
Fair value of milestone rights           $ 18,400,000              
Senior convertible notes due December 31, 2019 | Deerfield | Milestone Rights Liability | Danbury Facility                          
Debt Instrument [Line Items]                          
Carrying value               28,700,000          
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset                          
Debt Instrument [Line Items]                          
Debt facility principal amount               $ 20,000,000 $ 20,000,000        
Senior notes, effective interest rate               8.75%          
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset | Minimum                          
Debt Instrument [Line Items]                          
Available amount of credit facility under covenant restrictions               $ 25,000,000          
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset | Minimum | Facility Agreement                          
Debt Instrument [Line Items]                          
Available amount of credit facility under covenant restrictions               $ 25,000,000          
Senior convertible notes due December 31, 2019 | Sanofi-Aventis Deutschland GmbH | Milestone Rights Liability                          
Debt Instrument [Line Items]                          
Interest expense on notes                   1,900,000      
Required payment pursuant to the terms of the Milestone Agreement                   $ 5,000,000