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Fair Value of Financial Instruments (Detail) - USD ($) $ in Millions	Dec. 31, 2016	Dec. 31, 2015
Warrant Liability
Financial liabilities:
Financial liabilities fair value	$ 7.4
Carrying Value
Financial liabilities:
Financial liabilities fair value	115.2	$ 155.6
Carrying Value | Sanofi-Aventis Deutschland GmbH
Financial liabilities:
Financial liabilities fair value		44.5
Carrying Value | Warrant Liability
Financial liabilities:
Financial liabilities fair value	7.4
Carrying Value | Milestone Rights Liability
Financial liabilities:
Financial liabilities fair value	8.9	8.9
Carrying Value | Senior Convertible Notes | Convertible Debt Securities
Financial liabilities:
Financial liabilities fair value	27.6	27.6
Carrying Value | Facility Financing Obligation
Financial liabilities:
Financial liabilities fair value	71.3	74.6
Estimate of Fair Value Measurement
Financial liabilities:
Financial liabilities fair value	123.2	150.6
Estimate of Fair Value Measurement | Sanofi-Aventis Deutschland GmbH
Financial liabilities:
Financial liabilities fair value		36.5
Estimate of Fair Value Measurement | Warrant Liability
Financial liabilities:
Financial liabilities fair value	7.4
Estimate of Fair Value Measurement | Milestone Rights Liability
Financial liabilities:
Financial liabilities fair value	18.4	14.4
Estimate of Fair Value Measurement | Fair Value, Inputs, Level 3
Financial liabilities:
Financial liabilities fair value	123.2	150.6
Estimate of Fair Value Measurement | Fair Value, Inputs, Level 3 | Sanofi-Aventis Deutschland GmbH
Financial liabilities:
Financial liabilities fair value		36.5
Estimate of Fair Value Measurement | Fair Value, Inputs, Level 3 | Warrant Liability
Financial liabilities:
Financial liabilities fair value	7.4
Estimate of Fair Value Measurement | Fair Value, Inputs, Level 3 | Milestone Rights Liability
Financial liabilities:
Financial liabilities fair value	18.4	14.4
Estimate of Fair Value Measurement | Senior Convertible Notes | Convertible Debt Securities
Financial liabilities:
Financial liabilities fair value	22.9	21.3
Estimate of Fair Value Measurement | Senior Convertible Notes | Fair Value, Inputs, Level 3 | Convertible Debt Securities
Financial liabilities:
Financial liabilities fair value	22.9	21.3
Estimate of Fair Value Measurement | Facility Financing Obligation
Financial liabilities:
Financial liabilities fair value	74.5	78.4
Estimate of Fair Value Measurement | Facility Financing Obligation | Fair Value, Inputs, Level 3
Financial liabilities:
Financial liabilities fair value	$ 74.5	$ 78.4

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- Definition

Fair value of financial obligations, including, but not limited to, debt instruments, derivative liabilities, federal funds purchased and sold under agreements to repurchase, securities loaned or sold under agreements to repurchase, financial instruments sold not yet purchased, guarantees, line of credit, loans and notes payable, servicing liability, and trading liabilities.

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