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Statements of Stockholders' (Deficit) - USD ($)
$ in Thousands
Total
TEL AVIV STOCK EXCHANGE
Common Stock
Common Stock
TEL AVIV STOCK EXCHANGE
Additional Paid-in Capital
Additional Paid-in Capital
TEL AVIV STOCK EXCHANGE
Accumulated Other Comprehensive Income (Loss)
Deficit Accumulated During the Development Stage
Beginning Balance (in shares) at Dec. 31, 2013     73,878,000          
Beginning Balance at Dec. 31, 2013 $ (30,713)   $ 3,697   $ 2,261,996   $ (4) $ (2,296,402)
Exercise of stock options (in shares)     650,000          
Exercise of stock options 10,978   $ 35   10,943      
Issuance of common shares from the release of restricted stock units (in shares)     799,000          
Issuance of common shares from the release of restricted stock units (26,908)   $ 38   (26,946)      
Issuance of common shares pursuant to warrant exercises (in shares)     2,315,000          
Issuance of common shares pursuant to warrant exercises $ 27,779   $ 115   27,664      
Issuance of common shares under Employee Stock Purchase Plan (in shares) 61,015   65,000          
Issuance of common shares under Employee Stock Purchase Plan $ 1,363   $ 2   1,361      
Stock-based compensation expense 25,660       25,660      
Issuance of common shares pursuant to debt conversions by Deerfield (in Shares)     3,505,000          
Issuance of common shares pursuant to debt conversions by Deerfield 93,501   $ 174   93,327      
Remeasurement of performance based grants pursuant to the modification of terms $ 22,962       22,962      
Return of loaned common stock (in shares) (1,800,000)              
Unrealized gain/(loss) on foreign currency translation $ (10)           (10)  
Net income (loss) (198,382)             (198,382)
Ending Balance (in shares) at Dec. 31, 2014     81,212,000          
Ending Balance at Dec. 31, 2014 (73,770)   $ 4,061   2,416,967   (14) (2,494,784)
Exercise of stock options (in shares)     340,000          
Exercise of stock options 3,258   $ 17   3,241      
Issuance of common shares from the release of restricted stock units (in shares)     144,000          
Issuance of common shares from the release of restricted stock units     $ 7   (7)      
Issuance of common shares pursuant to warrant exercises (in shares)     843,000          
Issuance of common shares pursuant to warrant exercises $ 10,123   $ 42   10,081      
Issuance of common shares under Employee Stock Purchase Plan (in shares) 64,245   54,000          
Issuance of common shares under Employee Stock Purchase Plan $ 887   $ 3   884      
Stock-based compensation expense 8,725       8,725      
Restricted stock units taxes paid in cash (1,856)       (1,856)      
Capital contribution 40       40      
Issuance of common shares pursuant to conversions of certain 2015 note holders (in shares)     375,000          
Issuance of common shares pursuant to conversions of certain 2015 notes 7,926   $ 19   7,907      
Issuance of common stock for lender financing fees (in shares)     8,000          
Issuance of common stock for lender financing fees 160       160      
Discount on notes-for-stock exchange 169       169      
Return of loaned common stock (in shares)     (1,800,000)          
Return of loaned common stock     $ (90)   90      
Issuance of common stock 27,843 $ 34,710 $ 89 $ 139 27,754 $ 34,571    
Issuance of common stock (Shares)     1,788,000 2,771,000        
Issuance of warrant liability (202)       (202)      
Reclassification of warrant liability to equity 109       109      
Unrealized gain/(loss) on foreign currency translation (6)           (6)  
Net income (loss) (368,445)             (368,445)
Ending Balance (in shares) at Dec. 31, 2015     85,735,000          
Ending Balance at Dec. 31, 2015 $ (350,329)   $ 4,287   2,508,633   (20) (2,863,229)
Exercise of stock options (in shares) 55,231   55,000          
Exercise of stock options $ 467   $ 3   464      
Issuance of common shares from the release of restricted stock units (in shares)     131,000          
Issuance of common shares from the release of restricted stock units     $ 7   (7)      
Issuance of common shares under Employee Stock Purchase Plan (in shares) 104,758   51,000          
Issuance of common shares under Employee Stock Purchase Plan $ 426   $ 2   424      
Stock-based compensation expense 5,135       5,135      
Restricted stock units taxes paid in cash (165)       (165)      
Issuance of direct placement - common stock and warrants (value) 50,000   $ 485   49,515      
Issuance of direct placement - common stock and warrants (shares)     9,709,000          
Issuance costs associated with direct placement (2,037)       (2,037)      
Issuance of warrant liability (12,750)       (12,750)      
Unrealized gain/(loss) on foreign currency translation (4)           (4)  
Net income (loss) 125,664             125,664
Ending Balance (in shares) at Dec. 31, 2016     95,681,000          
Ending Balance at Dec. 31, 2016 $ (183,593)   $ 4,784   $ 2,549,212   $ (24) $ (2,737,565)