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Summary of Stock Options Outstanding (Detail) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2016 USD ($) $ / shares shares
Number of Shares
Outstanding at January 1, 2016 | shares	3,955,845
Granted | shares	2,236,693
Exercised | shares	(55,231)
Forfeited | shares	(407,161)
Expired | shares	(199,890)
Outstanding at December 31, 2016 | shares	5,530,256
Vested and expected to vest at December 31, 2016 | shares	5,399,777
Exercisable at December 31, 2016 | shares	3,414,586
Weighted Average Exercise Price per Share
Outstanding at January 1, 2016 | $ / shares	$ 22.70
Granted | $ / shares	4.50
Exercised | $ / shares	8.45
Forfeited | $ / shares	13.60
Expired | $ / shares	23.65
Outstanding at December 31, 2016 | $ / shares	16.10
Vested and expected to vest at December 31, 2016 | $ / shares	16.35
Exercisable at December 31, 2016 | $ / shares	$ 22.50
Aggregate Intrinsic Value
Outstanding at December 31, 2016 | $	$ 2
Vested and expected to vest at December 31, 2016 | $	2
Exercisable at December 31, 2016 | $	$ 0

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Share-based Compensation Arrangement by Share-based Payment Award, Options, Aggregate Intrinsic Value [Abstract]

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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Number of options or other stock instruments for which the right to exercise has lapsed under the terms of the plan agreements.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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Gross number of share options (or share units) granted during the period.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of fully vested and expected to vest options outstanding.

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As of the balance sheet date, the number of shares into which fully vested and expected to vest stock options outstanding can be converted under the option plan.

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As of the balance sheet date, the weighted-average exercise price for outstanding stock options that are fully vested or expected to vest.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options of the plan that expired.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options that were terminated.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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