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Selected Quarterly Financial Data - Additional Information (Detail) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Nov. 09, 2016
Dec. 31, 2016
Sep. 30, 2016
Dec. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Interim Reporting [Line Items]            
Asset impairment charges       $ 242,700    
Net revenue from collaboration         $ 171,965  
Gain (loss) on extinguishment of debt         72,024 $ (1,049)
License and Collaboration Agreement with Sanofi            
Interim Reporting [Line Items]            
Gain (loss) on extinguishment of debt $ 500          
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH            
Interim Reporting [Line Items]            
Net revenue from collaboration   $ 10,200 $ 161,800   $ 172,000  
Gain (loss) on extinguishment of debt   $ 72,000