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Collaboration Arrangements - Additional Information (Detail) - USD ($) |  |  |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Dec. 30, 2016 | Nov. 09, 2016 | Feb. 10, 2016 | Jan. 04, 2016 | Jan. 31, 2017 | Sep. 30, 2016 | Mar. 31, 2017 | Mar. 31, 2016 | Dec. 31, 2016 | Dec. 31, 2015 | Sep. 23, 2014
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Net revenue from collaboration |  |  |  |  |  |  | $ 63,000 |  |  |  |
Paid-in-kind interest |  |  |  |  |  |  |  | $ 1,168,000 |  |  |
Insulin Put |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Net revenue from collaboration |  |  |  |  |  |  |  |  | $ 10,200,000 |  |
Sanofi-Aventis Deutschland GmbH | Put Option |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Payment for insulin put option |  |  |  |  | $ 30,600,000 |  |  |  | $ 30,600,000 |  |
Aventisub LLC |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Outstanding loan balance forgiven |  | $ 72,000,000 |  |  |  |  |  |  |  |  |
License and Collaboration Agreement with Sanofi |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Profits and losses sharing percentage |  |  |  |  |  |  | 35.00% |  |  |  |
Termination date |  |  |  | Apr. 04, 2016 |  |  |  |  |  |  |
Maximum secured loan facility |  |  |  |  |  |  |  |  |  |  | $ 175,000,000
Senior notes, effective interest rate |  |  |  |  |  |  |  |  |  |  | 8.50%
Gain on extinguishment of debt |  | $ 500,000 |  |  |  |  |  |  |  |  |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Deferred revenue - nonrefundable license fee |  |  |  |  |  |  | $ 150,000,000 |  |  |  |
Net revenue from collaboration |  |  |  |  |  |  | $ 172,000,000 |  |  |  |
Profits and losses sharing percentage |  |  |  |  |  |  | 65.00% |  |  |  |
Milestone receivable |  |  |  |  |  |  | $ 25,000,000 |  |  |  |
Deferred cost |  |  |  |  |  |  |  |  |  | $ 13,500,000 |
Secured loan facility, amount borrowed |  |  | $ 17,900,000 |  |  |  |  |  |  | 44,500,000 |
Secured loan facility, amount owed |  |  |  |  |  | $ 71,200,000 |  |  |  |  |
Paid-in-kind interest |  |  |  |  |  | $ 5,800,000 |  |  |  |  |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH | Up Front Payment [Member] |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Net revenue from collaboration |  |  |  |  |  |  | 150,000,000 |  |  |  |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH | Milestone Payment One |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Net revenue from collaboration |  |  |  |  |  |  | 25,000,000 |  |  |  |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH | Milestone Payment Two |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Net revenue from collaboration |  |  |  |  |  |  | 25,000,000 |  |  |  |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH | AFREZZA product sales |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Deferred revenue - nonrefundable license fee |  |  |  |  |  |  |  |  |  | 17,500,000 |
Net revenue from collaboration |  |  |  |  |  |  | 17,500,000 |  |  |  |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH | Insulin Put |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Net revenue from collaboration |  |  |  |  |  |  | 19,400,000 |  |  |  |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH | Operating loss Sharing |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Net revenue from collaboration |  |  |  |  |  |  | (64,900,000) |  |  |  |
Company's total portion of loss sharing |  |  |  |  |  |  |  |  |  | $ 57,700,000 |
Receptor |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Nonrefundable payments |  |  |  |  |  |  | 400,000 |  |  |  |
Nonrefundable option exercise and license fee | $ 1,000,000 |  |  |  |  |  |  |  |  |  |
Reduction in research and development expense |  |  |  |  |  |  | 400,000 |  |  |  |
Deferred revenue - nonrefundable license fee |  |  |  |  |  |  | $ 1,000,000 |  |  |  |
Deferred revenue recognition period |  |  |  |  |  |  | 4 years |  |  |  |
Net revenue from collaboration |  |  |  |  |  |  | $ 100,000 |  |  |  |

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