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Fair Value of Financial Instruments - Additional Information (Detail) - USD ($) | 3 Months Ended |  |
--- | --- | --- | ---
Mar. 31, 2017 | Dec. 31, 2016 | Jul. 01, 2013
Fair Value of Financial Instruments [Line Items] |  |  |
Cash equivalents, money market funds | $ 47,400,000 | $ 20,500,000 |
Fair value of the liability, percentage increase | 8.00% |  |
Fair value of the liability, percentage decrease | 7.00% |  |
Maximum |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |
Probabilities of meeting the milestones, percentage decrease | 10.00% |  |
Fair value of the liability, percentage decrease | 30.00% |  |
Minimum |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |
Probabilities of meeting the milestones, percentage decrease | 5.00% |  |
Fair value of the liability, percentage decrease | 17.00% |  |
Milestone Rights Liability | Deerfield |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |
Long term liability | $ 8,900,000 |  |
Milestone Rights Liability | Deerfield | Maximum |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |
Contingent liability for milestone payments | 90,000,000 |  | $ 90,000,000
Milestone Rights Liability | Senior convertible notes due December 31, 2019 | Deerfield |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |
Long term liability | 7,300,000 | 8,900,000 |
Warrant Liability |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |
Fair value of warrants liability | $ 800,000 | $ 7,400,000 |
Valuation technique | Monte Carlo valuation pricing model |  |
Fair value assumption, risk-free rate | 1.24% |  |
Warrant liability fair value assumptions, dividend yield | 0.00% |  |
Warrant liability fair value assumptions, remaining term | 1 year 1 month 6 days |  |
Fair value assumption, stock price volatility | 100.00% |  |
Fair Value, Inputs, Level 3 | Milestone Rights Liability |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |
Fair value of warrants liability | $ 18,900,000 |  |
Fair Value, Inputs, Level 3 | Market Approach Valuation Technique | 5.75% Senior convertible notes due August 15, 2018 | Senior Convertible Notes |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |
Fair value assumption, risk-free rate | 20.00% |  |
Fair value assumption, stock price volatility | 115.00% |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Senior convertible notes due December 31, 2019 |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |
Market discount rate | 12.00% |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Milestone Rights Liability |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |
Market discount rate | 14.50% |  |

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- Definition Expected dividends to be paid to holders of the underlying shares or financial instruments (expressed as a percentage of the share or instrument's price). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bbb) -URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258 + Details
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