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Borrowings - Additional Information (Detail)
3 Months Ended 12 Months Ended
Aug. 10, 2015
d
$ / shares
Mar. 31, 2017
USD ($)
Mar. 31, 2016
USD ($)
Dec. 31, 2014
USD ($)
shares
Dec. 31, 2016
USD ($)
Jul. 28, 2015
USD ($)
Jul. 01, 2013
USD ($)
Debt Instrument [Line Items]              
Facility Agreement, total principle payment in 2017   $ 20,000,000          
Facility Agreement, total principle payment in 2018   20,000,000          
Facility Agreement, total principle payment in 2019   35,000,000          
Other liabilities   117,600,000     $ 123,200,000    
Milestone Rights Liability              
Debt Instrument [Line Items]              
Other liabilities   18,900,000     18,400,000    
Less portion of commitment asset              
Debt Instrument [Line Items]              
Cash repayment of senior notes under exchange agreement   4,000,000          
Conversion of debt   $ 1,000,000          
Deerfield              
Debt Instrument [Line Items]              
Principal repayment schedule, start date   Jul. 01, 2016          
Principal repayment schedule, end date   Dec. 09, 2019          
Conversion Option, value       $ 93,500,000      
Conversion Option, shares | shares       3,464,616      
Amortization of notes premium   $ 447,000 $ 419,000        
Deerfield | Milestone Rights Liability              
Debt Instrument [Line Items]              
Long term liability   8,900,000          
Deerfield | Milestone Rights Liability | Maximum              
Debt Instrument [Line Items]              
Contingent liability for milestone payments   90,000,000         $ 90,000,000
Deerfield | Tranche 1 Notes              
Debt Instrument [Line Items]              
Conversion Option, value       $ 20,000,000      
Deerfield | Tranche 2 note              
Debt Instrument [Line Items]              
Conversion Option, value       33,500,000      
Deerfield | Tranche 3 note              
Debt Instrument [Line Items]              
Conversion Option, value       $ 40,000,000      
Senior convertible notes due December 31, 2019              
Debt Instrument [Line Items]              
Debt facility principal amount   75,000,000     75,000,000    
Conversion of debt   5,000,000          
Carrying value   71,795,000     71,339,000    
Senior convertible notes due December 31, 2019 | Deerfield              
Debt Instrument [Line Items]              
Debt facility principal amount   $ 55,000,000          
Senior notes, effective interest rate   9.75%          
Accrued expenses   $ 1,600,000          
Other current liabilities   1,600,000          
Other liabilities   8,900,000          
Senior convertible notes due December 31, 2019 | Deerfield | Milestone Rights Liability              
Debt Instrument [Line Items]              
Long term liability   7,300,000     8,900,000    
Senior convertible notes due December 31, 2019 | Deerfield | Milestone Rights Liability | Danbury Facility              
Debt Instrument [Line Items]              
Carrying value   28,500,000          
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset              
Debt Instrument [Line Items]              
Debt facility principal amount   $ 20,000,000          
Senior notes, effective interest rate   8.75%          
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset | Minimum              
Debt Instrument [Line Items]              
Available amount of credit facility under covenant restrictions   $ 25,000,000          
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset | Minimum | Facility Agreement              
Debt Instrument [Line Items]              
Available amount of credit facility under covenant restrictions   25,000,000          
5.75% Senior convertible notes due August 15, 2018              
Debt Instrument [Line Items]              
Debt facility principal amount   27,690,000     27,690,000    
Senior notes, effective interest rate 5.75%            
Carrying value   $ 27,642,000     $ 27,635,000    
No of convertible shares 29            
Principal amount per share | $ / shares $ 1,000            
Conversion price of shares | $ / shares $ 34.00            
Percentage of repurchase price 100.00%            
Debt Instrument, redemption description   On or after the date that is one year following the original issue date of the 2018 notes, the Company will have the right to redeem for cash all or part of the 2018 notes if the last reported sale price of its common stock exceeds 130% of the conversion price then in effect for 20 or more trading days during the 30 consecutive trading day period ending on the trading day immediately prior to the date of the redemption notice. The redemption price will equal the sum of 100% of the principal amount of the 2018 notes to be redeemed, plus accrued and unpaid interest.          
Percentage of conversion price equaling stock price 130.00%            
Number of trading days | d 20            
Consecutive trading days 30 days            
Debt Issuance Cost           $ 800,000  
Amortization of notes premium   $ 59,000 57,000        
Accretion of debt issuance costs   $ 66,000 $ 62,000