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Fair Value of Financial Instruments - Additional Information (Detail) - USD ($)	3 Months Ended
	Mar. 31, 2017	Dec. 31, 2016	Jul. 01, 2013
Fair Value of Financial Instruments [Line Items]
Cash equivalents, money market funds	$ 47,400,000	$ 20,500,000
Fair value of the liability, percentage increase	8.00%
Fair value of the liability, percentage decrease	7.00%
Maximum
Fair Value of Financial Instruments [Line Items]
Probabilities of meeting the milestones, percentage decrease	10.00%
Fair value of the liability, percentage decrease	30.00%
Minimum
Fair Value of Financial Instruments [Line Items]
Probabilities of meeting the milestones, percentage decrease	5.00%
Fair value of the liability, percentage decrease	17.00%
Milestone Rights Liability | Deerfield
Fair Value of Financial Instruments [Line Items]
Long term liability	$ 8,900,000
Milestone Rights Liability | Deerfield | Maximum
Fair Value of Financial Instruments [Line Items]
Contingent liability for milestone payments	90,000,000		$ 90,000,000
Milestone Rights Liability | Senior convertible notes due December 31, 2019 | Deerfield
Fair Value of Financial Instruments [Line Items]
Long term liability	7,300,000	8,900,000
Warrant Liability
Fair Value of Financial Instruments [Line Items]
Fair value of warrants liability	$ 800,000	$ 7,400,000
Valuation technique	Monte Carlo valuation pricing model
Fair value assumption, risk-free rate	1.24%
Warrant liability fair value assumptions, dividend yield	0.00%
Warrant liability fair value assumptions, remaining term	1 year 1 month 6 days
Fair value assumption, stock price volatility	100.00%
Fair Value, Inputs, Level 3 | Milestone Rights Liability
Fair Value of Financial Instruments [Line Items]
Fair value of warrants liability	$ 18,900,000
Fair Value, Inputs, Level 3 | Market Approach Valuation Technique | 5.75% Senior convertible notes due August 15, 2018 | Senior Convertible Notes
Fair Value of Financial Instruments [Line Items]
Fair value assumption, risk-free rate	20.00%
Fair value assumption, stock price volatility	115.00%
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Senior convertible notes due December 31, 2019
Fair Value of Financial Instruments [Line Items]
Market discount rate	12.00%
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Milestone Rights Liability
Fair Value of Financial Instruments [Line Items]
Market discount rate	14.50%

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Fair value of liability, percentage decrease.

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Expected dividends to be paid to holders of the underlying shares or financial instruments (expressed as a percentage of the share or instrument's price).

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
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-Topic 820
-SubTopic 10
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Period the instrument, asset or liability is expected to be outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Measure of dispersion, in percentage terms (for instance, the standard deviation or variance), for a given stock price.

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Risk-free interest rate assumption used in valuing an instrument.

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Interest rate used to find the present value of an amount to be paid or received in the future as an input to measure fair value. For example, but not limited to, weighted average cost of capital (WACC), cost of capital, cost of equity and cost of debt.

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Fair value of financial and nonfinancial obligations.

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Investment in short-term money-market instruments (such as commercial paper, banker's acceptances, repurchase agreements, government securities, certificates of deposit, and so forth) which are highly liquid (that is, readily convertible to known amounts of cash) and so near their maturity that they present an insignificant risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify as cash equivalents by definition. Original maturity means an original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three-years ago does not become a cash equivalent when its remaining maturity is three months.

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Amount of long-term debt classified as other, payable after one year or the operating cycle, if longer.

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