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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net loss $ (16,324) $ (24,873)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:    
Depreciation, amortization and accretion 908 1,023
Stock-based compensation expense 1,267 1,273
Loss on foreign currency translation 1,545 2,364
Interest incurred through borrowings under Sanofi Loan Facility   1,168
Interest on note payable to principal stockholder 714 721
Change in fair value of warrant liability (6,629)  
Other, net   696
Changes in operating assets and liabilities:    
Accounts receivable, net (136) (121)
Receivable from Sanofi 30,557  
Inventory (1,367)  
Deferred costs from commercial product sales (163)  
Prepaid expenses and other current assets 856 1,211
Other assets 39 (86)
Accounts payable (1,665) (14,799)
Accrued expenses and other current liabilities 1,077 488
Deferred payments from collaboration (63) 177
Deferred revenue - net (1,575)  
Recognized loss on purchase commitments (534)  
Net cash provided by (used in) operating activities 8,507 (30,758)
CASH FLOWS FROM INVESTING ACTIVITIES:    
Purchase of property and equipment   (1,144)
Net proceeds from sale of property and equipment 16,651 17
Net cash provided by (used in) investing activities 16,651 (1,127)
CASH FLOWS FROM FINANCING ACTIVITIES:    
Proceeds from issuance of common stock   467
Payment of employment taxes related to vested restricted stock units (75) (3)
Net cash provided by (used in) financing activities (75) 464
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS 25,083 (31,421)
CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD 22,895 59,074
CASH AND CASH EQUIVALENTS, END OF PERIOD 47,978 27,653
SUPPLEMENTAL CASH FLOWS DISCLOSURES:    
Interest paid in cash, net of amounts capitalized $ 2,550 2,713
Cost incurred for construction in progress included in accounts payable and accrued liabilities   $ 558