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Condensed Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Revenues:        
Net revenue-commercial product sales $ 1,548   $ 2,745  
Net revenue-collaboration 63   125  
Revenue-other 552   2,302  
Total revenues 2,163   5,172  
Expenses:        
Cost of goods sold 5,086 $ 4,045 7,635 $ 9,213
Research and development 3,123 4,310 6,251 9,440
Selling, general and administrative 18,566 11,110 33,956 18,460
Property and equipment impairment 111   111  
(Gain) loss on foreign currency translation 6,848 (341) 8,392 2,023
Total expenses 33,734 19,124 56,345 39,136
Loss from operations (31,571) (19,124) (51,173) (39,136)
Other income (expense):        
Change in fair value of warrant liability 147 (5,306) 6,776 (5,306)
Interest income 58 26 114 41
Interest expense on notes (2,422) (4,181) (5,128) (8,401)
Interest expense on note payable to principal stockholder (721) (721) (1,435) (1,443)
Loss on extinguishment of debt (830)   (830)  
Other income   (653) 13 (586)
Total other expense (3,768) (10,835) (490) (15,695)
Loss before benefit for income taxes (35,339) (29,959) (51,663) (54,831)
Income tax benefit 0 0 0 0
Net loss $ (35,339) $ (29,959) $ (51,663) $ (54,831)
Net loss per share-basic and diluted $ (0.35) $ (0.33) $ (0.53) $ (0.62)
Shares used to compute basic and diluted net loss per share 99,864 91,061 97,816 88,416