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Fair Value of Financial Instruments - Additional Information (Detail) $ in Millions |  | 9 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Sep. 29, 2017 WarrantHolder shares | Sep. 29, 2017 shares WarrantHolder | Sep. 30, 2017 USD ($) | Dec. 31, 2016 USD ($) | May 12, 2016 USD ($)
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Cash equivalents, money market funds |  |  | $ 18.4 | $ 20.5 |
Warrants issued, fair value |  |  |  |  | $ 12.8
Number of warrant holders | shares |  | 4 |  |  |
Fair value of the liability, percentage decrease |  |  | 7.00% |  |
Minimum |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Probabilities of meeting the milestones, percentage decrease |  |  | 5.00% |  |
Fair value of the liability, percentage decrease |  |  | 16.00% |  |
Maximum |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Probabilities of meeting the milestones, percentage decrease |  |  | 10.00% |  |
Fair value of the liability, percentage decrease |  |  | 30.00% |  |
Milestone Rights Liability | Deerfield |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Long term liability |  |  | $ 8.9 |  |
Milestone Rights Liability | Senior convertible notes due December 31, 2019 | Deerfield |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Long term liability |  |  | 7.2 | 8.9 |
Warrant Liability |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Fair value of warrants liability |  |  |  | $ 7.4 |
Valuation technique |  |  |  | Monte Carlo valuation pricing model |
Fair value assumption, risk-free rate |  |  |  | 1.14% |
Warrant liability fair value assumptions, dividend yield |  |  |  | 0.00% |
Warrant liability fair value assumptions, remaining term |  |  |  | 1 year 4 months 25 days |
Fair value assumption, stock price volatility |  |  |  | 118.00% |
Fair Value, Inputs, Level 3 | Milestone Rights Liability |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Fair value of warrants liability |  |  | $ 18.7 |  |
Fair Value, Inputs, Level 3 | Market Approach Valuation Technique | 5.75% Senior convertible notes due August 15, 2018 | Senior Convertible Notes |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Fair value assumption, risk-free rate |  |  | 20.00% |  |
Fair value assumption, stock price volatility |  |  | 107.00% |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Senior convertible notes due December 31, 2019 |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Market discount rate |  |  | 12.00% |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Milestone Rights Liability |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Market discount rate |  |  | 14.00% |  |
Warrant Exchange Agreement |  |  |  |  |
Fair Value of Financial Instruments [Line Items] |  |  |  |  |
Number of warrant holders | WarrantHolder | 4 | 4 |  |  |
Outstanding warrants | shares | 9,700,000 | 9,700,000 |  |  |

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