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Borrowings - Additional Information (Detail) |  |  |  |  | 3 Months Ended | 9 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Oct. 23, 2017 USD ($) d $ / shares | Jun. 29, 2017 USD ($) $ / shares shares | Apr. 18, 2017 USD ($) $ / shares shares | Aug. 10, 2015 d $ / shares | Sep. 30, 2017 USD ($) | Sep. 30, 2016 USD ($) | Sep. 30, 2017 USD ($) | Sep. 30, 2016 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($) | Jul. 01, 2013 USD ($)
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Loss on extinguishment of debt |  |  |  |  |  |  | $ 830,000 |  |  |  |
Cash and cash equivalents |  |  |  |  | $ 20,092,000 | $ 35,530,000 | 20,092,000 | $ 35,530,000 | $ 22,895,000 | $ 59,074,000 |
Facility Agreement, total principle payment in 2017 |  |  |  |  | 10,000,000 |  | 10,000,000 |  |  |  |
Facility Agreement, total principle payment in 2018 |  |  |  |  | 20,000,000 |  | 20,000,000 |  |  |  |
Facility Agreement, total principle payment in 2019 |  |  |  |  | 30,000,000 |  | 30,000,000 |  |  |  |
Other liabilities |  |  |  |  | 103,400,000 |  | 103,400,000 |  | 123,200,000 |  |
Milestone Rights Liability |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Other liabilities |  |  |  |  | 18,700,000 |  | $ 18,700,000 |  | 18,400,000 |  |
Deerfield |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Principal repayment schedule, start date |  |  |  |  |  |  | Jul. 01, 2016 |  |  |  |
Principal repayment schedule, end date |  |  |  |  |  |  | Dec. 09, 2019 |  |  |  |
Deerfield | Milestone Rights Liability |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Long term liability |  |  |  |  | 8,900,000 |  | $ 8,900,000 |  |  |  |
Deerfield | Milestone Rights Liability | Maximum |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contingent liability for milestone payments |  |  |  |  | 90,000,000 |  | 90,000,000 |  |  |  | $ 90,000,000
Senior convertible notes due December 31, 2019 |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Exchange price per share | $ / shares |  | $ 1.45 | $ 1.22 |  |  |  |  |  |  |  |
Loss on extinguishment of debt |  | $ 500,000 |  |  |  |  |  |  |  |  |
Cash repayment |  |  | $ 4,000,000 |  |  |  |  |  |  |  |
Debt extinguishment amount |  | 5,000,000 |  |  |  |  |  |  |  |  |
Debt discount and issuance costs |  | 300,000 |  |  |  |  |  |  |  |  |
Debt facility principal amount |  |  |  |  | 60,000,000 |  | 60,000,000 |  | 75,000,000 |  |
Carrying value |  |  |  |  | 57,942,000 |  | 57,942,000 |  | 71,339,000 |  |
Senior convertible notes due December 31, 2019 | Less portion of commitment asset |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Loss on extinguishment of debt |  |  | 300,000 |  |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Debt facility principal amount |  |  |  |  | $ 45,000,000 |  | $ 45,000,000 |  |  |  |
Senior notes, effective interest rate |  |  |  |  | 9.75% |  | 9.75% |  |  |  |
Accrued expenses |  |  |  |  | $ 1,600,000 |  | $ 1,600,000 |  |  |  |
Other current liabilities |  |  |  |  | 1,600,000 |  | 1,600,000 |  |  |  |
Other liabilities |  |  |  |  | 8,900,000 |  | 8,900,000 |  | 8,900,000 |  |
Senior convertible notes due December 31, 2019 | Deerfield | Facility Agreement Third Amendment [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Cash repayment of senior notes under exchange agreement |  | 10,000,000 |  |  |  |  |  |  |  |  |
Conversion of notes to common shares, value |  | $ 5,000,000 |  |  |  |  |  |  |  |  |
Conversion Option, shares | shares |  | 3,584,230 |  |  |  |  |  |  |  |  |
Exchange price per share | $ / shares |  | $ 1.395 |  |  |  |  |  |  |  |  |
Cash and cash equivalents |  | $ 10,000,000 |  |  |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Minimum | Facility Agreement Third Amendment [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents |  | $ 25,000,000 |  |  | 10,000,000 |  | 10,000,000 |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Cash repayment of senior notes under exchange agreement |  |  | 4,000,000 |  |  |  |  |  |  |  |
Conversion of notes to common shares, value |  |  | $ 1,000,000 |  |  |  |  |  |  |  |
Debt facility principal amount |  |  |  |  | $ 15,000,000 |  | $ 15,000,000 |  |  |  |
Senior notes, effective interest rate |  |  |  |  | 8.75% |  | 8.75% |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset | Facility Agreement |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Available amount of credit facility under covenant restrictions |  |  |  |  | $ 10,000,000 |  | $ 10,000,000 |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset | Minimum |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Available amount of credit facility under covenant restrictions |  |  |  |  | 25,000,000 |  | 25,000,000 |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset | Minimum | Facility Agreement |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Available amount of credit facility under covenant restrictions |  |  |  |  | 25,000,000 |  | 25,000,000 |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Tranche B Exchange Shares |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Conversion Option, shares | shares |  |  | 869,565 |  |  |  |  |  |  |  |
Exchange price per share | $ / shares |  |  | $ 1.15 |  |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Tranche 1 Notes |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Conversion of notes to common shares, value |  |  | $ 5,000,000 |  |  |  |  |  |  |  |
Conversion Option, shares | shares |  |  | 4,347,826 |  |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Milestone Rights Liability |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Long term liability |  |  |  |  | 7,200,000 |  | 7,200,000 |  | 8,900,000 |  |
Senior convertible notes due December 31, 2019 | Deerfield | Milestone Rights Liability | Assets Including Property and Equipment |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Carrying value |  |  |  |  | 27,400,000 |  | 27,400,000 |  |  |  |
5.75% Senior convertible notes due August 15, 2018 |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Debt discount and issuance costs |  |  |  |  | 70,000 | $ 65,000 | 204,000 | $ 190,000 |  |  |
Debt facility principal amount |  |  |  |  | 27,690,000 |  | 27,690,000 |  | 27,690,000 |  |
Senior notes, effective interest rate |  |  |  | 5.75% |  |  |  |  |  |  |
Carrying value |  |  |  |  | 27,657,000 |  | $ 27,657,000 |  | $ 27,635,000 |  |
No of convertible shares |  |  |  | 29 |  |  |  |  |  |  |
Principal amount per share | $ / shares |  |  |  | $ 1,000 |  |  |  |  |  |  |
Percentage of repurchase price |  |  |  | 100.00% |  |  |  |  |  |  |
Debt Instrument, redemption description |  |  |  |  |  |  | On or after the date that is one year following the original issue date of the 2018 notes, the Company would have had the right to redeem for cash all or part of the 2018 notes if the last reported sale price of its common stock exceeds 130% of the conversion price then in effect for 20 or more trading days during the 30 consecutive trading day period ending on the trading day immediately prior to the date of the redemption notice. The redemption price was equal the sum of 100% of the principal amount of the 2018 notes to be redeemed, plus accrued and unpaid interest. |  |  |  |
Percentage of conversion price equaling stock price |  |  |  | 130.00% |  |  |  |  |  |  |
Number of trading days | d |  |  |  | 20 |  |  |  |  |  |  |
Consecutive trading days |  |  |  | 30 days |  |  |  |  |  |  |
Debt Issuance Cost |  |  |  |  | $ 800,000 |  | $ 800,000 |  |  |  |
5.75% Senior convertible notes due August 15, 2018 | Subsequent Event |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Debt facility principal amount | $ 27,690,000 |  |  |  |  |  |  |  |  |  |
5.75% Senior convertible notes due October 23, 2021 | Subsequent Event |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Debt facility principal amount | $ 23,690,000 |  |  |  |  |  |  |  |  |  |
Senior notes, effective interest rate | 5.75% |  |  |  |  |  |  |  |  |  |
No of convertible shares | 194.1748 |  |  |  |  |  |  |  |  |  |
Principal amount per share | $ / shares | $ 1,000 |  |  |  |  |  |  |  |  |  |
Percentage of repurchase price | 100.00% |  |  |  |  |  |  |  |  |  |
Percentage of conversion price equaling stock price | 120.00% |  |  |  |  |  |  |  |  |  |
Number of trading days | d | 10 |  |  |  |  |  |  |  |  |  |

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