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Components of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 507,235 | $ 712,124
Research and development credits | 83,461 | 77,998
Capitalized research | 1,016 | 5,117
Milestone Rights | 1,908 | 3,242
Accrued expenses | 211 | 440
Loss on purchase commitment | 23,654 | 36,775
Non-qualified stock option expense | 7,004 | 17,331
Capitalized patent costs | 5,194 | 8,781
Other | 795 | 7,380
Depreciation | 23,820 | 45,310
Total net deferred tax assets | 654,298 | 914,498
Valuation allowance | (654,298) | (914,498)
Net deferred tax assets | $ 0 | $ 0

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