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Selected Quarterly Financial Data - Additional Information (Detail) - USD ($) $ in Thousands |  | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Nov. 09, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Interim Reporting [Line Items] |  |  |  |  |  |  |
Net revenue - collaboration |  |  |  |  | $ 250 | $ 171,965 |
(Loss) gain on extinguishment of debt |  |  |  |  | (1,611) | 72,024 | $ (1,049)
Net revenue - commercial product sales |  | $ 1,200 |  |  | $ 9,192 | 1,895 |
License and Collaboration Agreement with Sanofi |  |  |  |  |  |  |
Interim Reporting [Line Items] |  |  |  |  |  |  |
(Loss) gain on extinguishment of debt | $ 500 |  |  |  |  |  |
License and Collaboration Agreement with Sanofi | Sanofi-Aventis Deutschland GmbH |  |  |  |  |  |  |
Interim Reporting [Line Items] |  |  |  |  |  |  |
Net revenue - collaboration |  |  | $ 10,200 | $ 161,800 |  | $ 172,000 |
(Loss) gain on extinguishment of debt |  |  | $ 72,000 |  |  |  |

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- Definition Difference between the fair value of payments made and the carrying amount of debt which is extinguished prior to maturity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 50 -Section 40 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=49170532&loc=d3e12317-112629 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 50 -Section 40 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=49170532&loc=d3e12355-112629 + Details
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