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Borrowings - Additional Information (Detail) |  |  |  |  | 3 Months Ended | 12 Months Ended |
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Nov. 06, 2017 USD ($) $ / shares shares | Oct. 23, 2017 USD ($) d $ / shares shares | Jun. 29, 2017 USD ($) $ / shares shares | Apr. 18, 2017 USD ($) $ / shares shares | Sep. 30, 2018 USD ($) | Mar. 31, 2015 USD ($) | Dec. 31, 2017 USD ($) shares | Dec. 31, 2016 USD ($) shares | Dec. 31, 2015 USD ($) shares | Jul. 01, 2013 USD ($)
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  | $ 157,800,000 |  |  |
Cash repayment of senior notes under exchange agreement |  |  |  |  |  |  |  |  | $ 64,287,000 |
Loss on extinguishment of debt |  |  |  |  |  |  | 1,611,000 | $ (72,024,000) | 1,049,000 |
Cash and cash equivalents |  |  |  |  |  |  | 43,946,000 | 22,895,000 |  |
Facility Agreement, total principle payment in 2018 |  |  |  |  |  |  | 24,400,000 |  |  |
Facility Agreement, total principle payment in 2019 |  |  |  |  |  |  | 30,000,000 |  |  |
Interest expense on notes |  |  |  |  |  |  | 9,494,000 | 15,576,000 | 21,231,000 |
Carrying value of the milestone rights liability |  |  |  |  |  |  | 12,449,000 | 7,937,000 |  |
Other liabilities |  |  |  |  |  |  | $ 93,500,000 | $ 123,200,000 |  |
Common stock, shares issued | shares |  |  |  |  |  |  | 119,053,414 | 95,680,831 |  |
Accretion expense - debt discount |  |  |  |  |  |  | $ 1,700,000 | $ 1,722,000 | $ 1,553,000 |
Common Stock |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Number of shares sold in underwritten public offering | shares |  | 973,236 |  |  |  |  | 173,000 |  | 1,788,000 |
Milestone Rights Liability |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Other liabilities |  |  |  |  |  |  | $ 19,100,000 | $ 18,400,000 |  |
Deerfield |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Principal repayment schedule, start date |  |  |  |  |  |  | Jul. 01, 2016 |  |  |
Principal repayment schedule, end date |  |  |  |  |  |  | Dec. 09, 2019 |  |  |
Deerfield | Less portion of commitment asset |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Senior notes, effective interest rate |  |  |  |  |  |  |  | 8.75% |  |
Deerfield | Milestone Rights Liability |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Long term liability |  |  |  |  |  |  | $ 8,900,000 |  |  |
Deerfield | Milestone Rights Liability | Maximum |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Contingent liability for milestone payments |  |  |  |  |  |  | 90,000,000 |  |  | $ 90,000,000
Senior convertible notes due December 31, 2019 |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Exchange price per share | $ / shares |  |  | $ 1.45 | $ 1.22 |  |  |  |  |  |
Loss on extinguishment of debt |  |  | $ 5,000,000 |  |  |  |  |  |  |
Cash repayment |  |  |  | $ 4,000,000 |  |  |  |  |  |
Debt extinguishment amount |  |  | 500,000 |  |  |  |  |  |  |
Debt discount and issuance costs |  |  | 300,000 |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Less portion of commitment asset |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  | 54,407,000 | $ 75,000,000 |  |
Loss on extinguishment of debt |  |  |  | 300,000 |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  | $ 39,400,000 | 55,000,000 |  |
Senior notes, effective interest rate |  |  |  |  |  |  | 9.75% |  |  |
Carrying value of the milestone rights liability |  |  |  |  |  |  | $ 1,600,000 |  |  |
Other liabilities |  |  |  |  |  |  | 8,900,000 | 8,900,000 |  |
Senior convertible notes due December 31, 2019 | Deerfield | Facility Agreement Third Amendment [Member] |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Cash repayment of senior notes under exchange agreement |  |  | 10,000,000 |  |  |  |  |  |  |
Conversion of notes to common shares, value |  |  | $ 5,000,000 |  |  |  |  |  |  |
Conversion Option, shares | shares |  |  | 3,584,230 |  |  |  |  |  |  |
Exchange price per share | $ / shares |  |  | $ 1.395 |  |  |  |  |  |  |
Cash and cash equivalents |  |  | $ 10,000,000 |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Minimum | Facility Agreement Third Amendment [Member] |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents |  |  | $ 25,000,000 |  |  |  | 10,000,000 |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Less portion of commitment asset |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  | $ 15,000,000 | 20,000,000 |  |
Senior notes, effective interest rate |  |  |  |  |  |  | 8.75% |  |  |
Cash repayment of senior notes under exchange agreement |  |  |  | 4,000,000 |  |  |  |  |  |
Conversion of notes to common shares, value |  |  |  | $ 1,000,000 |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Tranche B Exchange Shares |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Conversion Option, shares | shares |  |  |  | 869,565 |  |  |  |  |  |
Exchange price per share | $ / shares |  |  |  | $ 1.15 |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Tranche B Exchange Shares | Fourth Amendment to Facility Agreement |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Conversion of notes to common shares, value | $ 5,592,750 |  |  |  |  |  |  |  |  |
Conversion Option, shares | shares | 1,720,846 |  |  |  |  |  |  |  |  |
Conversion price of shares | $ / shares | $ 3.25 |  |  |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Tranche 1 Notes |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Conversion of notes to common shares, value |  |  |  | $ 5,000,000 |  |  |  |  |  |
Conversion Option, shares | shares |  |  |  | 4,347,826 |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Milestone Rights Liability |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Short term liability |  |  |  |  |  |  |  |  |  | 3,200,000
Long term liability |  |  |  |  |  |  | $ 7,200,000 | 8,900,000 |  | $ 13,100,000
Interest expense on notes |  |  |  |  |  | $ 5,800,000 |  |  |  |
Required payment pursuant to the terms of the Milestone Agreement |  |  |  |  |  | $ 10,000,000 |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Milestone Rights Liability | Scenario Forecast |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Required payment pursuant to the terms of the Milestone Agreement |  |  |  |  | $ 5,000,000 |  |  |  |  |
2019 Notes and Tranche B Notes |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Other liabilities |  |  |  |  |  |  | 54,600,000 | 74,500,000 |  |
2019 Notes and Tranche B Notes | Fourth Amendment to Facility Agreement |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Deferred payment of credit facility principal amount |  | $ 10,000,000 |  |  |  |  |  |  |  |
2019 Notes and Tranche B Notes | Deerfield | Tranche B Exchange Shares | Fourth Amendment to Facility Agreement |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Number of trading days | d |  | 3 |  |  |  |  |  |  |  |
Conversion price of shares | $ / shares |  | $ 3.25 |  |  |  |  |  |  |  |
2019 Notes and Tranche B Notes | Deerfield | Tranche B Exchange Shares | Maximum | Common Stock | Fourth Amendment to Facility Agreement |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Number of shares sold in underwritten public offering | shares |  | 4,000,000 |  |  |  |  |  |  |  |
5.75% Senior convertible notes due August 15, 2018 |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Principal amount |  | $ 27,690,000 |  |  |  |  |  |  |  |
Senior notes, effective interest rate |  | 5.75% |  |  |  |  |  |  |  |
Loss on extinguishment of debt |  |  |  |  |  |  | 800,000 |  |  |
Debt discount and issuance costs |  |  |  |  |  |  | 200,000 | 300,000 |  |
Conversion price of shares | $ / shares |  | $ 34 |  |  |  |  |  |  |  |
Other liabilities |  |  |  |  |  |  |  | 22,900,000 |  |
Unamortized debt issuance costs |  |  |  |  |  |  | 300,000 |  |  |
Unamortized premium |  |  |  |  |  |  | 200,000 |  |  |
Accretion expense - debt discount |  |  |  |  |  |  | 200,000 | 200,000 |  |
5.75% Senior convertible notes due October 23, 2021 |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Principal amount |  | $ 23,690,000 |  |  |  |  | 23,690,000 | 27,690,000 |  |
Senior notes, effective interest rate |  | 5.75% |  |  |  |  |  |  |  |
Number of trading days | d |  | 10 |  |  |  |  |  |  |  |
Conversion price of shares | $ / shares |  | $ 5.15 |  |  |  |  |  |  |  |
Other liabilities |  |  |  |  |  |  | 19,800,000 |  |  |
Unamortized debt issuance costs |  |  |  |  |  |  |  | 481,000 |  |
Unamortized premium |  | $ 800,000 |  |  |  |  | 721,000 | $ 426,000 |  |
No of convertible shares |  | 194.1748 |  |  |  |  |  |  |  |
Principal amount per share | $ / shares |  | $ 1,000 |  |  |  |  |  |  |  |
Percentage of repurchase price |  | 100.00% |  |  |  |  |  |  |  |
Percentage of conversion price equaling stock price |  | 120.00% |  |  |  |  |  |  |  |
Consecutive trading days | d |  | 20 |  |  |  |  |  |  |  |
Debt instrument, convertible, threshold business days |  | 5 years |  |  |  |  |  |  |  |
Accretion expense - debt discount |  |  |  |  |  |  | $ 30,000 |  |  |
5.75% Senior convertible notes due October 23, 2021 | Maximum |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Common stock, shares issued | shares |  | 13,648,300 |  |  |  |  |  |  |  |

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