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Subsequent Events - Additional Information (Detail) |  |  |  | 12 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Jan. 18, 2018 USD ($) d $ / shares shares | Jan. 15, 2018 USD ($) | Oct. 23, 2017 shares | Dec. 31, 2017 $ / shares shares | Dec. 31, 2015 shares | Dec. 13, 2017 $ / shares | Jun. 29, 2017 $ / shares | Apr. 18, 2017 $ / shares | Dec. 31, 2016 $ / shares shares
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |
Common stock, shares issued | shares |  |  |  | 119,053,414 |  |  |  |  | 95,680,831
Common stock, par value |  |  |  | $ 0.01 |  | $ 0.01 |  |  | $ 0.01
Common Stock |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |
Number of shares sold in underwritten public offering | shares |  |  | 973,236 | 173,000 | 1,788,000 |  |  |  |
Senior convertible notes due December 31, 2019 |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |
Exchange price per share |  |  |  |  |  |  | $ 1.45 | $ 1.22 |
Senior convertible notes due December 31, 2019 | Deerfield | Tranche B Exchange Shares |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |
Exchange price per share |  |  |  |  |  |  |  | $ 1.15 |
Subsequent Event | Senior convertible notes due December 31, 2019 | Deerfield | Fifth Amendment to Facility Agreement |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |
Deferred payment of credit facility principal amount | $ |  | $ 4,400,000 |  |  |  |  |  |  |
Subsequent Event | Senior convertible notes due December 31, 2019 | Deerfield | Sixth Amendment to Facility Agreement |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |
Deferred payment of credit facility principal amount | $ | $ 1,250,000 |  |  |  |  |  |  |  |
Common stock, shares issued | shares | 1,267,972 |  |  |  |  |  |  |  |
Common stock, par value | $ 0.01 |  |  |  |  |  |  |  |
Conversion of notes to common shares, value | $ | $ 3,157,251 |  |  |  |  |  |  |  |
Exchange price per share | $ 2.49 |  |  |  |  |  |  |  |
Subsequent Event | Senior convertible notes due December 31, 2019 | Deerfield | Sixth Amendment to Facility Agreement | Tranche B Exchange Shares |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |
Number of trading days | d | 3 |  |  |  |  |  |  |  |
Conversion price of shares | $ 2.75 |  |  |  |  |  |  |  |
Subsequent Event | Senior convertible notes due December 31, 2019 | Deerfield | Sixth Amendment to Facility Agreement | Common Stock | Tranche B Exchange Shares |  |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |  |
Number of shares sold in underwritten public offering | shares | 10,000,000 |  |  |  |  |  |  |  |

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