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Description of Business - Additional Information (Detail) |  | 12 Months Ended |  |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Mar. 01, 2017 shares | Dec. 31, 2017 USD ($) shares | Dec. 13, 2017 shares | Jun. 29, 2017 USD ($) | Dec. 31, 2016 USD ($) shares | Sep. 30, 2016 shares | Dec. 31, 2015 USD ($) | Jan. 01, 2015 USD ($)
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Accumulated deficit |  | $ (2,854,898,000) |  |  | $ (2,737,565,000) |  |  |
Cash and cash equivalents |  | 43,946,000 |  |  | $ 22,895,000 |  |  |
Principal amount of outstanding borrowings |  | $ 157,800,000 |  |  |  |  |  |
Stock split of common stock | 0.2 |  |  |  |  |  |  |
Reverse stock split, description |  | The Company’s board of directors approved a 1-for-5 reverse stock split of its outstanding common stock. On March 1, 2017, the Company filed with the Secretary of State of the State of Delaware a Certificate of Amendment of the Company’s Amended and Restated Certificate of Incorporation (the “Charter Amendment”) to effect the 1-for-5 reverse stock split of the Company’s outstanding common stock (the “Reverse Stock Split”) and to reduce the authorized number of shares of the Company’s common stock from 700,000,000 to 140,000,000 shares. The Company’s common stock began trading on the NASDAQ Global Market on a split-adjusted basis when the market opened on March 3, 2017. As a result, all common stock share amounts included in these consolidated financial statements have been retroactively reduced by a factor of five, and all common stock per share amounts have been increased by a factor of five, with the exception of the Company’s common stock par value. |  |  |  |  |  |
Common stock, shares authorized | shares | 140,000,000 | 280,000,000 | 280,000,000 |  | 140,000,000 | 700,000,000 |  |
Common stock |  | $ 1,192,000 |  |  | $ 957,000 |  |  |
Additional paid-in capital |  | 2,638,992,000 |  |  | 2,553,039,000 |  |  |
Adjustments |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Common stock |  |  |  |  | (3,800,000) |  | $ (3,400,000) | $ (3,200,000)
Additional paid-in capital |  |  |  |  | 3,800,000 |  | $ 3,400,000 | $ 3,200,000
Maximum |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Common stock, shares authorized | shares |  |  | 280,000,000 |  |  |  |  |
Minimum |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Common stock, shares authorized | shares |  |  | 140,000,000 |  |  |  |  |
Senior convertible notes due December 31, 2019 | Less portion of commitment asset |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Principal amount of outstanding borrowings |  | $ 54,407,000 |  |  | $ 75,000,000 |  |  |
Deerfield | Less portion of commitment asset |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Senior notes, effective interest rate |  |  |  |  | 8.75% |  |  |
Deerfield | Senior convertible notes due December 31, 2019 |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Senior notes, effective interest rate |  | 9.75% |  |  |  |  |  |
Principal amount of outstanding borrowings |  | $ 39,400,000 |  |  | $ 55,000,000 |  |  |
Deerfield | Senior convertible notes due December 31, 2019 | Less portion of commitment asset |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Senior notes, effective interest rate |  | 8.75% |  |  |  |  |  |
Principal amount of outstanding borrowings |  | $ 15,000,000 |  |  | $ 20,000,000 |  |  |
Deerfield | Senior convertible notes due December 31, 2019 | Minimum | Less portion of commitment asset |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Available amount of credit facility under covenant restrictions |  | $ 25,000,000 |  |  |  |  |  |
Deerfield | Senior convertible notes due December 31, 2019 | Minimum | Less portion of commitment asset | Third Amendment [Member] |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |
Available amount of credit facility under covenant restrictions |  |  |  | $ 10,000,000 |  |  |  |

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