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Income Taxes -Additional Information (Detail) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Aug. 31, 2004 | Dec. 31, 2017 | Mar. 31, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Income Taxes [Line Items] |  |  |  |  |  |  |
Provision for income taxes |  |  |  |  | $ 51 | $ 0 | $ 0
Valuation allowance of deferred tax asset |  | $ 654,298 |  |  | 654,298 | 914,498 |
Change in the valuation allowance |  |  |  |  | (260,200) | (48,100) |
Federal operating loss carryforwards |  | 2,000,000 |  |  | 2,000,000 |  |
State operating loss carryforwards |  | 2,200,000 |  |  | 2,200,000 |  |
Net operating loss carryforwards | $ 216,000 |  |  |  |  |  |
Net operating loss and credit carryforwards, annual use limitation | $ 13,000 |  |  |  |  |  |
Research and development credits |  | 83,461 |  |  | 83,461 | $ 77,998 |
Undistributed earnings from its foreign subsidiaries |  | 0 |  |  | $ 0 |  |
Effective income tax rate |  |  |  |  | 35.00% | 35.00% | 35.00%
Additional income tax expense or benefit |  | 0 |  |  | $ 0 |  |
Reduction for employee remuneration |  |  |  |  | 301,000 |  |
Decrease in valuation allowance |  |  |  |  | 301,000 |  |
Provisional amount recorded related to mandatory deemed repatriation of foreign earnings |  |  |  |  | 0 |  |
Scenario Forecast |  |  |  |  |  |  |
Income Taxes [Line Items] |  |  |  |  |  |  |
Effective income tax rate |  |  |  | 21.00% |  |  |
ASU 2016-09 |  |  |  |  |  |  |
Income Taxes [Line Items] |  |  |  |  |  |  |
Attributable to excess tax benefits on stock compensation |  |  | $ 10,800 |  |  |  |
Federal |  |  |  |  |  |  |
Income Taxes [Line Items] |  |  |  |  |  |  |
Research and development credits |  | 55,100 |  |  | $ 55,100 |  |
Federal research and development credits begin to expire |  |  |  |  | 2024 |  |
State |  |  |  |  |  |  |
Income Taxes [Line Items] |  |  |  |  |  |  |
Research and development credits |  | $ 28,400 |  |  | $ 28,400 |  |

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