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Fair Value of Financial Instruments - Additional Information (Detail) - USD ($) | 12 Months Ended |  |
--- | --- | --- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Jul. 01, 2013
Fair Value Of Financial Instruments [Line Items] |  |  |
Cash equivalents, money market funds | $ 41,000,000 | $ 20,500,000 |
Fair value of the liability, percentage decrease | 4.00% |  |
Milestone Rights Liability | Deerfield |  |  |
Fair Value Of Financial Instruments [Line Items] |  |  |
Long term liability | $ 8,900,000 |  |
Minimum |  |  |
Fair Value Of Financial Instruments [Line Items] |  |  |
Probabilities of meeting the milestones, amount | $ 50,000,000 |  |
Probabilities of meeting the milestones, percentage decrease | 5.00% |  |
Fair value of the liability, percentage decrease | 14.00% |  |
Maximum |  |  |
Fair Value Of Financial Instruments [Line Items] |  |  |
Probabilities of meeting the milestones, amount | $ 200,000,000 |  |
Probabilities of meeting the milestones, percentage decrease | 10.00% |  |
Fair value of the liability, percentage decrease | 28.00% |  |
Senior convertible notes due December 31, 2019 | Milestone Rights Liability | Deerfield |  |  |
Fair Value Of Financial Instruments [Line Items] |  |  |
Long term liability | $ 7,200,000 | $ 8,900,000 | $ 13,100,000
Fair Value, Inputs, Level 3 | Milestone Rights Liability |  |  |
Fair Value Of Financial Instruments [Line Items] |  |  |
Fair value of warrants liability | $ 19,100,000 |  |
Fair Value, Inputs, Level 3 | Market Approach Valuation Technique | 5.75% Senior convertible notes due October 23, 2021 | Senior Convertible Notes |  |  |
Fair Value Of Financial Instruments [Line Items] |  |  |
Fair value assumption, risk-free rate | 20.00% |  |
Fair value assumption, stock price volatility | 102.00% |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Milestone Rights Liability |  |  |
Fair Value Of Financial Instruments [Line Items] |  |  |
Market discount rate | 14.00% |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Senior convertible notes due December 31, 2019 | Minimum |  |  |
Fair Value Of Financial Instruments [Line Items] |  |  |
Market discount rate | 12.00% |  |
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Senior convertible notes due December 31, 2019 | Maximum |  |  |
Fair Value Of Financial Instruments [Line Items] |  |  |
Market discount rate | 13.00% |  |

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- Definition Fair value of liability percentage decrease if probabilities of meeting milestones percentage decrease. + References No definition available. + Details
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- Definition Measure of dispersion, in percentage terms (for instance, the standard deviation or variance), for a given stock price. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bbb) -URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258 + Details
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- Definition Interest rate used to find the present value of an amount to be paid or received in the future as an input to measure fair value. For example, but not limited to, weighted average cost of capital (WACC), cost of capital, cost of equity and cost of debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bbb) -URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258 + Details
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- Definition Investment in short-term money-market instruments (such as commercial paper, banker's acceptances, repurchase agreements, government securities, certificates of deposit, and so forth) which are highly liquid (that is, readily convertible to known amounts of cash) and so near their maturity that they present an insignificant risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify as cash equivalents by definition. Original maturity means an original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three-years ago does not become a cash equivalent when its remaining maturity is three months. + References No definition available. + Details
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