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Borrowings - Additional Information (Detail) |  |  |  |  |  |  |  |  | 1 Months Ended | 3 Months Ended |  |  |
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Mar. 12, 2018 USD ($) shares | Mar. 06, 2018 USD ($) d $ / shares shares | Jan. 18, 2018 USD ($) d $ / shares shares | Jan. 15, 2018 USD ($) | Nov. 06, 2017 USD ($) $ / shares shares | Oct. 23, 2017 USD ($) d $ / shares shares | Jun. 29, 2017 USD ($) $ / shares shares | Apr. 18, 2017 USD ($) $ / shares shares | Feb. 28, 2015 USD ($) | Mar. 31, 2018 USD ($) $ / shares shares | Dec. 31, 2017 USD ($) $ / shares shares | Mar. 31, 2017 USD ($) | Mar. 09, 2018 $ / shares | Sep. 30, 2017 USD ($) | Jul. 01, 2013 USD ($)
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  |  |  |  | $ 140,200,000 |  |  |  |  |
Loss on extinguishment of debt |  |  |  |  |  |  |  |  |  | 825,000 |  |  |  |  |
Cash and cash equivalents |  |  |  |  |  |  |  |  |  | $ 26,706,000 | $ 43,946,000 |  |  |  |
Common stock, shares issued | shares |  |  |  |  |  |  |  |  |  | 126,013,051 | 119,053,414 |  |  |  |
Common stock, par value | $ / shares |  |  |  |  |  |  |  |  |  | $ 0.01 | $ 0.01 |  |  |  |
Other liabilities |  |  |  |  |  |  |  |  |  | $ 156,600,000 | $ 93,500,000 |  |  |  |
Interest expense on notes |  |  |  |  |  |  |  |  | $ 5,800,000 | 1,794,000 |  | $ 2,706,000 |  |  |
Required payment pursuant to the terms of the Milestone Agreement |  |  |  |  |  |  |  |  | $ 10,000,000 |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares sold in underwritten public offering | shares |  |  |  |  |  | 973,236 |  |  |  |  |  |  |  |  |
Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  |  |  |  |  | 39,400,000 |  |  |  |
Tranche B Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  |  |  |  | $ 10,000,000 |  |  |  |  |
Senior notes, effective interest rate |  |  |  |  |  |  |  |  |  | 8.75% |  |  |  |  |
Tranche B Notes | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  |  |  |  |  | 15,000,000 |  |  |  |
Tranche B Exchange Shares | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Senior notes, effective interest rate | 8.75% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of notes to common shares, value | $ 5,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion Option, shares | shares | 1,838,236 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exchange price per share | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  | $ 2.72 |  |
Milestone Rights Liability |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Other liabilities |  |  |  |  |  |  |  |  |  | $ 17,800,000 | 19,100,000 |  |  |  |
Milestone Rights Liability | Deerfield | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent liability for milestone payments |  |  |  |  |  |  |  |  |  | 90,000,000 |  |  |  |  | $ 90,000,000
5.75% Senior convertible notes due October 23, 2021 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  | $ 23,700,000 |  |  |  | $ 23,690,000 | 23,690,000 |  |  |  |
Senior notes, effective interest rate |  |  |  |  |  | 5.75% |  |  |  | 5.75% |  |  |  |  |
Maturity date |  |  |  |  |  |  |  |  |  | Oct. 23, 2021 |  |  |  |  |
Conversion price of shares | $ / shares |  |  |  |  |  | $ 5.15 |  |  |  |  |  |  |  |  |
Other liabilities |  |  |  |  |  |  |  |  |  | $ 19,900,000 | 19,800,000 |  |  |  |
Unamortized premium |  |  |  |  |  |  |  |  |  | 678,000 | 721,000 |  |  |  |
5.75% Senior convertible notes due October 23, 2021 | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares issued | shares |  |  |  |  |  | 13,648,300 |  |  |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  |  |  |  | $ 35,000,000 |  |  |  |  |
Senior notes, effective interest rate |  |  |  |  |  |  |  |  |  | 9.75% |  |  |  |  |
Conversion of notes to common shares, value |  | $ 1,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Exchange price per share | $ / shares |  | $ 2.83 |  |  |  |  | $ 1.45 | $ 1.22 |  |  |  |  |  |  |
Loss on extinguishment of debt |  |  |  |  |  |  | $ 500,000 |  |  |  |  |  |  |  |
Cash repayment |  |  |  |  |  |  |  | $ 4,000,000 |  |  |  |  |  |  |
Debt extinguishment amount |  |  |  |  |  |  | 5,000,000 |  |  |  |  |  |  |  |
Debt discount and issuance costs |  |  |  |  |  |  | 300,000 |  |  |  |  |  |  |  |
Number of trading days | d |  | 3 |  |  |  |  |  |  |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion Option, shares | shares |  | 441,618 |  |  |  |  |  |  |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Senior notes, effective interest rate |  |  |  |  |  |  |  |  |  | 9.75% |  |  |  |  |
Accrued expenses |  |  |  |  |  |  |  |  |  | $ 1,600,000 |  |  |  |  |
Other current liabilities |  |  |  |  |  |  |  |  |  | 1,600,000 |  |  |  |  |
Other liabilities |  |  |  |  |  |  |  |  |  |  | 8,900,000 |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Facility Agreement Third Amendment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash repayment of senior notes under exchange agreement |  |  |  |  |  |  | 10,000,000 |  |  |  |  |  |  |  |
Conversion of notes to common shares, value |  |  |  |  |  |  | $ 5,000,000 |  |  |  |  |  |  |  |
Conversion Option, shares | shares |  |  |  |  |  |  | 3,584,230 |  |  |  |  |  |  |  |
Exchange price per share | $ / shares |  |  |  |  |  |  | $ 1.395 |  |  |  |  |  |  |  |
Cash and cash equivalents |  |  |  |  |  |  | $ 10,000,000 |  |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Deerfield | Minimum | Facility Agreement Third Amendment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents |  |  |  |  |  |  | $ 25,000,000 |  |  |  |  |  |  | $ 10,000,000 |
Senior convertible notes due December 31, 2019 | Tranche B Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  |  |  |  | $ 45,000,000 | 54,407,000 |  |  |  |
Loss on extinguishment of debt |  |  |  |  |  |  |  | 300,000 |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Tranche B Notes | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Senior notes, effective interest rate |  |  |  |  |  |  |  |  |  | 8.75% |  |  |  |  |
Cash repayment of senior notes under exchange agreement |  |  |  |  |  |  |  | 4,000,000 |  |  |  |  |  |  |
Conversion of notes to common shares, value |  |  |  |  |  |  |  | $ 1,000,000 |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Tranche B Exchange Shares | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion Option, shares | shares |  |  |  |  |  |  |  | 869,565 |  |  |  |  |  |  |
Exchange price per share | $ / shares |  |  |  |  |  |  |  | $ 1.15 |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Tranche 1 Notes | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of notes to common shares, value |  |  |  |  |  |  |  | $ 5,000,000 |  |  |  |  |  |  |
Conversion Option, shares | shares |  |  |  |  |  |  |  | 4,347,826 |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Milestone Rights Liability | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Long term liability |  |  |  |  |  |  |  |  |  | $ 7,200,000 | 8,900,000 |  |  |  |
Senior convertible notes due December 31, 2019 | Notes Due and Payable On July 2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  |  |  |  | 15,000,000 |  |  |  |  |
Senior convertible notes due December 31, 2019 | Notes Due and Payable On July 2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  |  |  |  | 15,000,000 |  |  |  |  |
Senior convertible notes due December 31, 2019 | Notes Due and Payable On December 2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  |  |  |  | 5,000,000 |  |  |  |  |
Senior convertible notes due December 31, 2019 | Fourth Amendment to Facility Agreement | Tranche B Exchange Shares | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of notes to common shares, value |  |  |  |  | $ 5,600,000 |  |  |  |  |  |  |  |  |  |
Conversion Option, shares | shares |  |  |  |  | 1,720,846 |  |  |  |  |  |  |  |  |  |
Conversion price of shares | $ / shares |  |  |  |  | $ 3.25 |  |  |  |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Fifth Amendment to Facility Agreement | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred payment of credit facility principal amount |  |  |  | $ 4,400,000 |  |  |  |  |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Sixth Amendment to Facility Agreement | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of notes to common shares, value |  |  | $ 3,200,000 |  |  |  |  |  |  |  |  |  |  |  |
Exchange price per share | $ / shares |  |  | $ 2.49 |  |  |  |  |  |  |  |  |  |  |  |
Deferred payment of credit facility principal amount |  |  | $ 1,300,000 |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares issued | shares |  |  | 1,267,972 |  |  |  |  |  |  |  |  |  |  |  |
Common stock, par value | $ / shares |  |  | $ 0.01 |  |  |  |  |  |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Sixth Amendment to Facility Agreement | Tranche B Exchange Shares | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of trading days | d |  |  | 3 |  |  |  |  |  |  |  |  |  |  |  |
Conversion price of shares | $ / shares |  |  | $ 2.75 |  |  |  |  |  |  |  |  |  |  |  |
Senior convertible notes due December 31, 2019 | Sixth Amendment to Facility Agreement | Tranche B Exchange Shares | Deerfield | Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares sold in underwritten public offering | shares |  |  | 10,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Notes Due and Payable On May 2019 | Tranche B Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  |  |  |  | 5,000,000 |  |  |  |  |
Notes Due and Payable On December 2019 | Tranche B Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  |  |  |  |  | 5,000,000 |  |  |  |  |
2019 Notes and Tranche B Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Other liabilities |  |  |  |  |  |  |  |  |  | $ 50,100,000 | 54,600,000 |  |  |  |
2019 Notes and Tranche B Notes | Fourth Amendment to Facility Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred payment of credit facility principal amount |  |  |  |  |  | $ 10,000,000 |  |  |  |  |  |  |  |  |
2019 Notes and Tranche B Notes | Fourth Amendment to Facility Agreement | Tranche B Exchange Shares | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of trading days | d |  |  |  |  |  | 3 |  |  |  |  |  |  |  |  |
Conversion price of shares | $ / shares |  |  |  |  |  | $ 3.25 |  |  |  |  |  |  |  |  |
2019 Notes and Tranche B Notes | Fourth Amendment to Facility Agreement | Tranche B Exchange Shares | Deerfield | Maximum | Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares sold in underwritten public offering | shares |  |  |  |  |  | 4,000,000 |  |  |  |  |  |  |  |  |
5.75% Senior convertible notes due August 15, 2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount |  |  |  |  |  | $ 27,700,000 |  |  |  |  |  |  |  |  |
Senior notes, effective interest rate |  |  |  |  |  | 5.75% |  |  |  |  |  |  |  |  |
Loss on extinguishment of debt |  |  |  |  |  |  |  |  |  |  | 800,000 |  |  |  |
Number of trading days | d |  |  |  |  |  | 10 |  |  |  |  |  |  |  |  |
Conversion price of shares | $ / shares |  |  |  |  |  | $ 34 |  |  |  |  |  |  |  |  |
Debt issuance costs |  |  |  |  |  |  |  |  |  |  | 300,000 |  |  |  |
Unamortized premium |  |  |  |  |  |  |  |  |  |  | $ 200,000 |  |  |  |
No of convertible shares |  |  |  |  |  | 194.1748 |  |  |  |  |  |  |  |  |
Principal amount per share | $ / shares |  |  |  |  |  | $ 1,000 |  |  |  |  |  |  |  |  |
Percentage of repurchase price |  |  |  |  |  | 100.00% |  |  |  |  |  |  |  |  |
Debt Instrument, redemption description |  |  |  |  |  |  |  |  |  | The Company may elect at its option to cause all or any portion of the 2021 notes to be mandatorily converted in whole or part at any time prior to the close of business on the business day immediately preceding the maturity date, if the last reported sale price of its common stock exceeds 120% of the conversion price then in effect for at least 10 trading days in any 20 consecutive trading day period, ending within five business days prior to the date of the mandatory conversion notice. The redemption price is equal the sum of 100% of the principal amount of the 2021 notes to be redeemed, plus accrued and unpaid interest. |  |  |  |  |
Percentage of conversion price equaling stock price |  |  |  |  |  | 120.00% |  |  |  |  |  |  |  |  |
Consecutive trading days |  |  |  |  |  | 20 days |  |  |  |  |  |  |  |  |
Debt Issuance Cost |  |  |  |  |  |  |  |  |  | $ 800,000 |  |  |  |  |

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