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Schedule of Adoption of New Revenue Guidance Impact on Condensed Consolidated Statement of Operations (Detail) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Revenues:    
Net revenue - commercial product sales $ 3,402 $ 1,196
Expenses:    
Cost of goods sold 4,008 2,548
Net loss (30,385) $ (16,324)
Adjustments | Accounting Standards Update 2014-09    
Revenues:    
Net revenue - commercial product sales 589  
Expenses:    
Cost of goods sold 44  
Net loss 545  
Balances Without Adoption of Topic 606 | Accounting Standards Update 2014-09    
Revenues:    
Net revenue - commercial product sales 3,991  
Expenses:    
Cost of goods sold 4,052  
Net loss $ (29,840)