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Schedule of Adoption of New Revenue Guidance Impact on Condensed Consolidated Statement of Cash Flows (Detail) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net loss $ (30,385) $ (16,324)
Changes in operating assets and liabilities:    
Accounts receivable, net 1,128 (136)
Deferred costs from commercial product sales   163
Accrued expenses and other current liabilities 2,675 1,077
Deferred revenue, net   (1,575)
Cash (used in) provided by operating activities (21,650) $ 8,507
Adjustments | Accounting Standards Update 2014-09    
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net loss 545  
Changes in operating assets and liabilities:    
Accounts receivable, net (18)  
Deferred costs from commercial product sales 44  
Accrued expenses and other current liabilities 171  
Deferred revenue, net (740)  
Cash (used in) provided by operating activities 2  
Balances Without Adoption of Topic 606 | Accounting Standards Update 2014-09    
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net loss (29,840)  
Changes in operating assets and liabilities:    
Accounts receivable, net 1,110  
Deferred costs from commercial product sales 44  
Accrued expenses and other current liabilities 2,846  
Deferred revenue, net (740)  
Cash (used in) provided by operating activities $ (21,648)