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Borrowings - Additional Information (Detail)									1 Months Ended	3 Months Ended
	Mar. 12, 2018 USD ($) shares	Mar. 06, 2018 USD ($) d $ / shares shares	Jan. 18, 2018 USD ($) d $ / shares shares	Jan. 15, 2018 USD ($)	Nov. 06, 2017 USD ($) $ / shares shares	Oct. 23, 2017 USD ($) d $ / shares shares	Jun. 29, 2017 USD ($) $ / shares shares	Apr. 18, 2017 USD ($) $ / shares shares	Feb. 28, 2015 USD ($)	Mar. 31, 2018 USD ($) $ / shares shares	Dec. 31, 2017 USD ($) $ / shares shares	Mar. 31, 2017 USD ($)	Mar. 09, 2018 $ / shares	Sep. 30, 2017 USD ($)	Jul. 01, 2013 USD ($)
Debt Instrument [Line Items]
Principal amount										$ 140,200,000
Loss on extinguishment of debt										825,000
Cash and cash equivalents										$ 26,706,000	$ 43,946,000
Common stock, shares issued | shares										126,013,051	119,053,414
Common stock, par value | $ / shares										$ 0.01	$ 0.01
Other liabilities										$ 156,600,000	$ 93,500,000
Interest expense on notes									$ 5,800,000	1,794,000		$ 2,706,000
Required payment pursuant to the terms of the Milestone Agreement									$ 10,000,000
Common Stock
Debt Instrument [Line Items]
Number of shares sold in underwritten public offering | shares						973,236
Deerfield
Debt Instrument [Line Items]
Principal amount											39,400,000
Tranche B Notes
Debt Instrument [Line Items]
Principal amount										$ 10,000,000
Senior notes, effective interest rate										8.75%
Tranche B Notes | Deerfield
Debt Instrument [Line Items]
Principal amount											15,000,000
Tranche B Exchange Shares | Deerfield
Debt Instrument [Line Items]
Senior notes, effective interest rate	8.75%
Conversion of notes to common shares, value	$ 5,000,000
Conversion Option, shares | shares	1,838,236
Exchange price per share | $ / shares													$ 2.72
Milestone Rights Liability
Debt Instrument [Line Items]
Other liabilities										$ 17,800,000	19,100,000
Milestone Rights Liability | Deerfield | Maximum
Debt Instrument [Line Items]
Contingent liability for milestone payments										90,000,000					$ 90,000,000
5.75% Senior convertible notes due October 23, 2021
Debt Instrument [Line Items]
Principal amount						$ 23,700,000				$ 23,690,000	23,690,000
Senior notes, effective interest rate						5.75%				5.75%
Maturity date										Oct. 23, 2021
Conversion price of shares | $ / shares						$ 5.15
Other liabilities										$ 19,900,000	19,800,000
Unamortized premium										678,000	721,000
5.75% Senior convertible notes due October 23, 2021 | Maximum
Debt Instrument [Line Items]
Common stock, shares issued | shares						13,648,300
Senior convertible notes due December 31, 2019
Debt Instrument [Line Items]
Principal amount										$ 35,000,000
Senior notes, effective interest rate										9.75%
Conversion of notes to common shares, value		$ 1,300,000
Exchange price per share | $ / shares		$ 2.83					$ 1.45	$ 1.22
Loss on extinguishment of debt							$ 500,000
Cash repayment								$ 4,000,000
Debt extinguishment amount							5,000,000
Debt discount and issuance costs							300,000
Number of trading days | d		3
Senior convertible notes due December 31, 2019 | Common Stock
Debt Instrument [Line Items]
Conversion Option, shares | shares		441,618
Senior convertible notes due December 31, 2019 | Deerfield
Debt Instrument [Line Items]
Senior notes, effective interest rate										9.75%
Accrued expenses										$ 1,600,000
Other current liabilities										1,600,000
Other liabilities											8,900,000
Senior convertible notes due December 31, 2019 | Deerfield | Facility Agreement Third Amendment
Debt Instrument [Line Items]
Cash repayment of senior notes under exchange agreement							10,000,000
Conversion of notes to common shares, value							$ 5,000,000
Conversion Option, shares | shares							3,584,230
Exchange price per share | $ / shares							$ 1.395
Cash and cash equivalents							$ 10,000,000
Senior convertible notes due December 31, 2019 | Deerfield | Minimum | Facility Agreement Third Amendment
Debt Instrument [Line Items]
Cash and cash equivalents							$ 25,000,000							$ 10,000,000
Senior convertible notes due December 31, 2019 | Tranche B Notes
Debt Instrument [Line Items]
Principal amount										$ 45,000,000	54,407,000
Loss on extinguishment of debt								300,000
Senior convertible notes due December 31, 2019 | Tranche B Notes | Deerfield
Debt Instrument [Line Items]
Senior notes, effective interest rate										8.75%
Cash repayment of senior notes under exchange agreement								4,000,000
Conversion of notes to common shares, value								$ 1,000,000
Senior convertible notes due December 31, 2019 | Tranche B Exchange Shares | Deerfield
Debt Instrument [Line Items]
Conversion Option, shares | shares								869,565
Exchange price per share | $ / shares								$ 1.15
Senior convertible notes due December 31, 2019 | Tranche 1 Notes | Deerfield
Debt Instrument [Line Items]
Conversion of notes to common shares, value								$ 5,000,000
Conversion Option, shares | shares								4,347,826
Senior convertible notes due December 31, 2019 | Milestone Rights Liability | Deerfield
Debt Instrument [Line Items]
Long term liability										$ 7,200,000	8,900,000
Senior convertible notes due December 31, 2019 | Notes Due and Payable On July 2018
Debt Instrument [Line Items]
Principal amount										15,000,000
Senior convertible notes due December 31, 2019 | Notes Due and Payable On July 2019
Debt Instrument [Line Items]
Principal amount										15,000,000
Senior convertible notes due December 31, 2019 | Notes Due and Payable On December 2019
Debt Instrument [Line Items]
Principal amount										5,000,000
Senior convertible notes due December 31, 2019 | Fourth Amendment to Facility Agreement | Tranche B Exchange Shares | Deerfield
Debt Instrument [Line Items]
Conversion of notes to common shares, value					$ 5,600,000
Conversion Option, shares | shares					1,720,846
Conversion price of shares | $ / shares					$ 3.25
Senior convertible notes due December 31, 2019 | Fifth Amendment to Facility Agreement | Deerfield
Debt Instrument [Line Items]
Deferred payment of credit facility principal amount				$ 4,400,000
Senior convertible notes due December 31, 2019 | Sixth Amendment to Facility Agreement | Deerfield
Debt Instrument [Line Items]
Conversion of notes to common shares, value			$ 3,200,000
Exchange price per share | $ / shares			$ 2.49
Deferred payment of credit facility principal amount			$ 1,300,000
Common stock, shares issued | shares			1,267,972
Common stock, par value | $ / shares			$ 0.01
Senior convertible notes due December 31, 2019 | Sixth Amendment to Facility Agreement | Tranche B Exchange Shares | Deerfield
Debt Instrument [Line Items]
Number of trading days | d			3
Conversion price of shares | $ / shares			$ 2.75
Senior convertible notes due December 31, 2019 | Sixth Amendment to Facility Agreement | Tranche B Exchange Shares | Deerfield | Common Stock
Debt Instrument [Line Items]
Number of shares sold in underwritten public offering | shares			10,000,000
Notes Due and Payable On May 2019 | Tranche B Notes
Debt Instrument [Line Items]
Principal amount										5,000,000
Notes Due and Payable On December 2019 | Tranche B Notes
Debt Instrument [Line Items]
Principal amount										5,000,000
2019 Notes and Tranche B Notes
Debt Instrument [Line Items]
Other liabilities										$ 50,100,000	54,600,000
2019 Notes and Tranche B Notes | Fourth Amendment to Facility Agreement
Debt Instrument [Line Items]
Deferred payment of credit facility principal amount						$ 10,000,000
2019 Notes and Tranche B Notes | Fourth Amendment to Facility Agreement | Tranche B Exchange Shares | Deerfield
Debt Instrument [Line Items]
Number of trading days | d						3
Conversion price of shares | $ / shares						$ 3.25
2019 Notes and Tranche B Notes | Fourth Amendment to Facility Agreement | Tranche B Exchange Shares | Deerfield | Maximum | Common Stock
Debt Instrument [Line Items]
Number of shares sold in underwritten public offering | shares						4,000,000
5.75% Senior convertible notes due August 15, 2018
Debt Instrument [Line Items]
Principal amount						$ 27,700,000
Senior notes, effective interest rate						5.75%
Loss on extinguishment of debt											800,000
Number of trading days | d						10
Conversion price of shares | $ / shares						$ 34
Debt issuance costs											300,000
Unamortized premium											$ 200,000
No of convertible shares						194.1748
Principal amount per share | $ / shares						$ 1,000
Percentage of repurchase price						100.00%
Debt Instrument, redemption description										The Company may elect at its option to cause all or any portion of the 2021 notes to be mandatorily converted in whole or part at any time prior to the close of business on the business day immediately preceding the maturity date, if the last reported sale price of its common stock exceeds 120% of the conversion price then in effect for at least 10 trading days in any 20 consecutive trading day period, ending within five business days prior to the date of the mandatory conversion notice. The redemption price is equal the sum of 100% of the principal amount of the 2021 notes to be redeemed, plus accrued and unpaid interest.
Percentage of conversion price equaling stock price						120.00%
Consecutive trading days						20 days
Debt Issuance Cost										$ 800,000

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