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Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2018 | Jun. 30, 2017
CASH FLOWS FROM OPERATING ACTIVITIES: |  |
Net loss | $ (53,060) | $ (51,663)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities: |  |
Depreciation, amortization and accretion | 1,459 | 1,787
Stock-based compensation expense | 4,152 | 2,516
Loss on extinguishment of debt, net | 53 | 830
Loss on sale, abandonment/disposal or impairment of property and equipment |  | 87
(Gain) Loss on foreign currency translation | (2,379) | 8,392
Interest on note payable to related party | 2,219 | 1,435
Change in fair value of warrant liability |  | (6,776)
Write-off of inventory | 779 | 1,460
Other, net | 106 | 3
Changes in operating assets and liabilities: |  |
Accounts receivable, net | (170) | (1,010)
Receivable from Sanofi |  | 30,557
Inventory | (1,798) | (2,301)
Deferred costs from commercial product sales |  | (191)
Prepaid expenses and other current assets | 440 | 1,800
Other assets | 79 | 125
Accounts payable | 2,253 | 3,357
Accrued expenses and other current liabilities | 818 | (483)
Deferred revenue |  | (827)
Deferred payments from collaboration | 2,049 | (125)
Recognized loss on purchase commitments | (5,800) | (500)
Net cash used in operating activities | (48,800) | (11,527)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |
Net proceeds from sale of asset held for sale |  | 16,651
Proceeds from sale of property and equipment |  | 24
Net cash provided by investing activities |  | 16,675
CASH FLOWS FROM FINANCING ACTIVITIES: |  |
Proceeds from direct placement of common stock | 28,000 |
Issuance cost associated with direct placement | (1,610) |
Principal payments on facility financing obligation |  | (4,000)
Borrowings on note payable to related party |  | 19,429
Payment of employment taxes related to vested restricted stock units | (184) | (88)
Proceeds from issuance of common stock pursuant to at-the-market issuance | 634 |
Issuance cost of at-the-market transactions | (25) |
Proceeds from executive stock purchase plan | 335 |
Net cash provided by financing activities | 27,150 | 15,341
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH | (21,650) | 20,489
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD | 48,355 | 22,895
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD | 26,705 | 43,384
SUPPLEMENTAL CASH FLOWS DISCLOSURES: |  |
Interest paid in cash, net of amounts capitalized | 1,860 | 4,141
NON-CASH INVESTING AND FINANCING ACTIVITIES: |  |
Payment of note obligations through common stock issuance, net of issuance costs | 20,405 | 11,000
Payment of note payable to related party through common stock issuance | 8,160 |
Capitalization of interest on note payable to related party |  | $ 10,716
Accrued but unpaid debt issuance costs | $ 156 |

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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the amount received from entity's raising of capital via private rather than public placement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash inflow from a long-term borrowing made from related parties where one party can exercise control or significant influence over another party; including affiliates, owners or officers and their immediate families, pension trusts, and so forth. Alternate caption: Proceeds from Advances from Affiliates. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash inflow from the sale of property, plant and equipment (capital expenditures), software, and other intangible assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3179-108585 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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