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Schedule of Adoption of New Revenue Guidance Impact on Condensed Consolidated Statement of Operations (Detail) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2018 | Jun. 30, 2017 | Jun. 30, 2018 | Jun. 30, 2017
Revenues: |  |  |  |
Net revenue - commercial product sales | $ 3,893 | $ 2,163 | $ 7,358 | $ 5,172
Expenses: |  |  |  |
Cost of goods sold | 5,095 | 5,086 | 9,103 | 7,635
Net loss | (22,675) | (35,339) | (53,060) | (51,663)
Adjustments | Accounting Standards Update 2014-09 |  |  |  |
Expenses: |  |  |  |
Cost of goods sold | (45) |  | (1) |
Net loss | (178) |  | 202 |
Balances Without Adoption of Topic 606 | Accounting Standards Update 2014-09 |  |  |  |
Expenses: |  |  |  |
Cost of goods sold | 5,050 |  | 9,102 |
Net loss | (22,853) |  | (52,858) |
Net revenue - commercial product sales |  |  |  |
Revenues: |  |  |  |
Net revenue - commercial product sales | 3,753 | $ 1,548 | 7,155 | $ 2,745
Net revenue - commercial product sales | Adjustments | Accounting Standards Update 2014-09 |  |  |  |
Revenues: |  |  |  |
Net revenue - commercial product sales | (388) |  | 201 |
Net revenue - commercial product sales | Balances Without Adoption of Topic 606 | Accounting Standards Update 2014-09 |  |  |  |
Revenues: |  |  |  |
Net revenue - commercial product sales | $ 3,365 |  | $ 7,356 |

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