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Schedule of Adoption of New Revenue Guidance Impact on Condensed Consolidated Statement of Cash Flows (Detail) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2018 | Jun. 30, 2017 | Jun. 30, 2018 | Jun. 30, 2017
Cash Flows from Operating Activities |  |  |  |
Net loss | $ (22,675) | $ (35,339) | $ (53,060) | $ (51,663)
Changes in operating assets and liabilities: |  |  |  |
Accounts receivable, net |  |  | (170) | (1,010)
Deferred costs from commercial product sales |  |  |  | 191
Accrued expenses and other current liabilities |  |  | 818 | (483)
Deferred revenue, net |  |  |  | $ (827)
Cash (used in) provided by operating activities |  |  | (48,800) |
Adjustments | Accounting Standards Update 2014-09 |  |  |  |
Cash Flows from Operating Activities |  |  |  |
Net loss | (178) |  | 202 |
Changes in operating assets and liabilities: |  |  |  |
Accounts receivable, net |  |  | (188) |
Deferred costs from commercial product sales |  |  | (1) |
Accrued expenses and other current liabilities |  |  | 170 |
Deferred revenue, net |  |  | (348) |
Cash (used in) provided by operating activities |  |  | (165) |
Balances Without Adoption of Topic 606 | Accounting Standards Update 2014-09 |  |  |  |
Cash Flows from Operating Activities |  |  |  |
Net loss | $ (22,853) |  | (52,858) |
Changes in operating assets and liabilities: |  |  |  |
Accounts receivable, net |  |  | (358) |
Deferred costs from commercial product sales |  |  | (1) |
Accrued expenses and other current liabilities |  |  | 988 |
Deferred revenue, net |  |  | (348) |
Cash (used in) provided by operating activities |  |  | $ (48,965) |

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