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Schedule of Adoption of New Revenue Guidance Impact on Condensed Consolidated Statement of Cash Flows (Detail) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Cash Flows from Operating Activities
Net loss	$ (22,675)	$ (35,339)	$ (53,060)	$ (51,663)
Changes in operating assets and liabilities:
Accounts receivable, net			(170)	(1,010)
Deferred costs from commercial product sales				191
Accrued expenses and other current liabilities			818	(483)
Deferred revenue, net				$ (827)
Cash (used in) provided by operating activities			(48,800)
Adjustments | Accounting Standards Update 2014-09
Cash Flows from Operating Activities
Net loss	(178)		202
Changes in operating assets and liabilities:
Accounts receivable, net			(188)
Deferred costs from commercial product sales			(1)
Accrued expenses and other current liabilities			170
Deferred revenue, net			(348)
Cash (used in) provided by operating activities			(165)
Balances Without Adoption of Topic 606 | Accounting Standards Update 2014-09
Cash Flows from Operating Activities
Net loss	$ (22,853)		(52,858)
Changes in operating assets and liabilities:
Accounts receivable, net			(358)
Deferred costs from commercial product sales			(1)
Accrued expenses and other current liabilities			988
Deferred revenue, net			(348)
Cash (used in) provided by operating activities			$ (48,965)

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