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Description of Business and Significant Accounting Policies (Tables) | 9 Months Ended
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Sep. 30, 2018
Summary Of Significant Accounting Policies [Line Items] |
Schedule of Potentially Dilutive Common Stock Equivalent Securities | The computation of basic and diluted net loss per share for the nine months ended September 30, 2018 and 2017 excludes the common stock equivalents of the following potentially dilutive securities because their inclusion would be anti-dilutive:
|  | September 30, |
|  | 2018 |  |  | 2017 |
Vesting of restricted stock units |  |  | 1,169,340 |  |  |  | 1,147,688 |
Employee stock purchase plan |  |  | 97,598 |  |  |  | 142,888 |
Exercise of common stock options |  |  | 11,431,526 |  |  |  | 7,183,837 |
Conversion of convertible notes into common stock |  |  | 3,629,627 |  |  |  | 814,561 |
Conversion of convertible related party notes into common stock |  |  | 21,909,541 |  |  |  | — |
Exercise of common stock warrants |  |  | 31,856 |  |  |  | 31,856 |
Exercise of warrants associated with direct placement |  |  | 14,000,000 |  |  |  | — |
|  |  | 52,269,488 |  |  |  | 9,320,830 |
Accounting Standards Update 2014-09 |
Summary Of Significant Accounting Policies [Line Items] |
Schedule of Cumulative Effect of Changes to Condensed Consolidated Balance Sheet for Adoption of New Revenue Guidance | The cumulative effect of the changes made to the condensed consolidated January 1, 2018 balance sheet for the adoption of the new revenue guidance was as follows (in thousands):
|  | Balance at December 31, 2017 |  |  | Adjustments due to new revenue guidance |  |  |  | Balance at January 1, 2018 |
Assets |  |  |  |  |  |  |  |  |  |  |  |  |
Accounts receivable, net |  | $ | 2,789 |  |  | $ | (111 | ) | (1) |  | $ | 2,678 |
Deferred costs from commercial product sales |  |  | 405 |  |  |  | (405 | ) | (2) |  |  | — |
Liabilities |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued expenses and other current liabilities |  | $ | 12,449 |  |  | $ | 649 |  | (3) |  | $ | 13,098 |
Deferred revenue, net |  |  | 3,038 |  |  |  | (3,038 | ) | (4) |  |  | — |
Equity |  |  |  |  |  |  |  |  |  |  |  |  |
Accumulated deficit |  | $ | (2,854,898 | ) |  | $ | 1,873 |  | (5) |  | $ | (2,853,025 | )
| (1) | To establish a reserve for product returns
| (2) | To eliminate deferred costs from commercial product sales previously required by the sell-through method
| (3) | To record additional accrual for estimated voucher payments related to inventory remaining in the distribution channel at January 1, 2018
| (4) | To eliminate deferred revenue previously required by the sell-through method
| (5) | To record the net impact of (1)-(4) in opening accumulated deficit
Schedule of Adoption of New Revenue Guidance Impact on Financial Statements | In accordance with the new revenue guidance, the disclosure of the impact of adoption on the condensed consolidated balance sheet and the condensed consolidated statement of operations and cash flows was as follows (in thousands):
Condensed Consolidated Balance Sheet |  |  |  |  |  |  |  |  |  |  |  |
|  | For the nine months ended September 30, 2018 |
|  | As Reported |  |  | Adjustments |  |  | Balances without adoption of Topic 606 |
Assets |  |  |  |  |  |  |  |  |  |  |  |
Accounts receivable, net |  | $ | 2,752 |  |  | $ | 417 |  |  | $ | 3,169 |
Deferred costs from commercial product sales |  |  | — |  |  |  | 763 |  |  |  | 763 |
Liabilities |  |  |  |  |  |  |  |  |  |  |  |
Accrued expenses and other current liabilities |  | $ | 13,434 |  |  | $ | (588 | ) |  | $ | 12,846 |
Deferred revenue, net |  |  | — |  |  |  | 3,601 |  |  |  | 3,601 |
Equity |  |  |  |  |  |  |  |  |  |  |  |
Accumulated deficit |  | $ | (2,930,249 | ) |  | $ | (1,833 | ) |  | $ | (2,932,082 | )
Condensed Consolidated Statement of Operations |  |  |  |  |  |  |  |  |  |  |  |
|  | For the nine months ended September 30, 2018 |
|  | As Reported |  |  | Adjustments |  |  | Balances without adoption of Topic 606 |
Revenue |  |  |  |  |  |  |  |  |  |  |  |
Net revenue - commercial product sales |  | $ | 11,542 |  |  | $ | (778 | ) |  | $ | 10,764 |
Expenses |  |  |  |  |  |  |  |  |  |  |  |
Cost of goods sold |  | $ | 14,406 |  |  | $ | (975 | ) |  | $ | 13,431 |
Net loss |  |  | (77,224 | ) |  |  | (196 | ) |  |  | (77,420 | )
|  | For the three months ended September 30, 2018 |
|  | As Reported |  |  | Adjustments |  |  | Balances without adoption of Topic 606 |
Revenue |  |  |  |  |  |  |  |  |  |  |  |
Net revenue - commercial product sales |  | $ | 4,387 |  |  | $ | (654 | ) |  | $ | 3,733 |
Expenses |  |  |  |  |  |  |  |  |  |  |  |
Cost of goods sold |  | $ | 5,303 |  |  | $ | (790 | ) |  | $ | 4,513 |
Net loss |  |  | (24,168 | ) |  |  | (137 | ) |  |  | (24,305 | )
|  | For the nine months ended September 30, 2018 |
|  | As Reported |  |  | Adjustments |  |  | Balances without adoption of Topic 606 |
Cash Flows from Operating Activities |  |  |  |  |  |  |  |  |  |  |  |
Net loss |  |  | (77,224 | ) |  | $ | (196 | ) |  | $ | (77,420 | )
Change in: |  |  |  |  |  |  |  |  |  |  |  |
Accounts receivable, net |  |  | (74 | ) |  |  | 111 |  |  |  | 37 |
Deferred costs from commercial product sales |  |  | — |  |  |  | 358 |  |  |  | 358 |
Accrued expenses and other current liabilities |  |  | 560 |  |  |  | (588 | ) |  |  | (28 | )
Deferred revenue, net |  |  | — |  |  |  | (563 | ) |  |  | (563 | )
Cash (used in) provided by operating activities |  |  | (62,719 | ) |  |  | (878 | ) |  |  | (63,597 | )

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