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Collaboration Arrangements - Additional Information (Detail) - USD ($) |  | 1 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | ---
Dec. 30, 2016 | May 31, 2018 | Jan. 31, 2017 | Sep. 30, 2018 | Oct. 16, 2018 | Dec. 31, 2016
Sanofi-Aventis Deutschland GmbH | Put Option |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Payment for insulin put option |  |  | $ 30,600,000 |  |  |
Collaboration and License Agreement | United Therapeutics Corporation |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Revenue recognized during the period |  |  |  | $ 0 |  |
Collaboration and License Agreement | United Therapeutics Corporation | Subsequent Event |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Upfront payment received |  |  |  |  | $ 45,000,000 |
Collaboration and License Agreement | United Therapeutics Corporation | Maximum |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Potential milestone payments to be receive |  |  |  | 50,000,000 |  |
Additional option exercise and development milestone payments to be receive |  |  |  | $ 40,000,000 |  |
Collaboration and License Agreement | Receptor |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Deferred revenue - nonrefundable license fee |  |  |  |  |  | $ 1,000,000
Deferred revenue recognition period |  |  |  | 4 years |  |
Nonrefundable option exercise and license fee | $ 1,000,000 |  |  |  |  |
Deferred payments from collaboration |  |  |  | $ 600,000 |  |
Deferred payments from collaboration, current |  |  |  | 300,000 |  |
Distribution Agreement | Foreign Country | India Tax Authority |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Income Taxes Paid |  |  |  | $ 200,000 |  |
Distribution Agreement | Cipla Ltd |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Marketing and distribution agreement date |  | 2018-05 |  |  |  |
Deferred revenue - nonrefundable license fee |  | $ 2,200,000 |  |  |  |
Deferred revenue recognition period |  |  |  | 15 years |  |
Research Agreement | United Therapeutics Corporation |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Revenue recognized during the period |  |  |  | $ 0 |  |
Upfront payment received |  |  |  | 10,000,000 |  |
Research Agreement | United Therapeutics Corporation | Maximum |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Additional milestone payments to be received |  |  |  | $ 30,000,000 |  |

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