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Schedule of Adoption of New Revenue Guidance Impact on Condensed Consolidated Statement of Cash Flows (Detail) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2018 | Sep. 30, 2017 | Sep. 30, 2018 | Sep. 30, 2017
Cash Flows from Operating Activities |  |  |  |
Net loss | $ (24,168) | $ (32,886) | $ (77,224) | $ (84,549)
Changes in operating assets and liabilities: |  |  |  |
Accounts receivable, net |  |  | (74) | (1,502)
Deferred costs from commercial product sales |  |  |  | 234
Accrued expenses and other current liabilities |  |  | 560 | 2,889
Deferred revenue, net |  |  |  | $ (398)
Cash (used in) provided by operating activities |  |  | (62,719) |
Adjustments | Accounting Standards Update 2014-09 |  |  |  |
Cash Flows from Operating Activities |  |  |  |
Net loss | (137) |  | (196) |
Changes in operating assets and liabilities: |  |  |  |
Accounts receivable, net |  |  | 111 |
Deferred costs from commercial product sales |  |  | 358 |
Accrued expenses and other current liabilities |  |  | (588) |
Deferred revenue, net |  |  | (563) |
Cash (used in) provided by operating activities |  |  | (878) |
Balances Without Adoption of Topic 606 | Accounting Standards Update 2014-09 |  |  |  |
Cash Flows from Operating Activities |  |  |  |
Net loss | $ (24,305) |  | (77,420) |
Changes in operating assets and liabilities: |  |  |  |
Accounts receivable, net |  |  | 37 |
Deferred costs from commercial product sales |  |  | 358 |
Accrued expenses and other current liabilities |  |  | (28) |
Deferred revenue, net |  |  | (563) |
Cash (used in) provided by operating activities |  |  | $ (63,597) |

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