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Schedule of Adoption of New Revenue Guidance Impact on Condensed Consolidated Statement of Cash Flows (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Cash Flows from Operating Activities
Net loss	$ (24,168)	$ (32,886)	$ (77,224)	$ (84,549)
Changes in operating assets and liabilities:
Accounts receivable, net			(74)	(1,502)
Deferred costs from commercial product sales				234
Accrued expenses and other current liabilities			560	2,889
Deferred revenue, net				$ (398)
Cash (used in) provided by operating activities			(62,719)
Adjustments | Accounting Standards Update 2014-09
Cash Flows from Operating Activities
Net loss	(137)		(196)
Changes in operating assets and liabilities:
Accounts receivable, net			111
Deferred costs from commercial product sales			358
Accrued expenses and other current liabilities			(588)
Deferred revenue, net			(563)
Cash (used in) provided by operating activities			(878)
Balances Without Adoption of Topic 606 | Accounting Standards Update 2014-09
Cash Flows from Operating Activities
Net loss	$ (24,305)		(77,420)
Changes in operating assets and liabilities:
Accounts receivable, net			37
Deferred costs from commercial product sales			358
Accrued expenses and other current liabilities			(28)
Deferred revenue, net			(563)
Cash (used in) provided by operating activities			$ (63,597)

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