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Income Taxes -Additional Information (Detail) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Aug. 31, 2004 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Income Taxes [Line Items] |  |  |  |
Provision for income taxes |  | $ 240,000 | $ 51,000 | $ 0
Valuation allowance of deferred tax asset |  | 665,365,000 | 654,298,000 |
Change in the valuation allowance |  | 11,100,000 | (260,200,000) |
Federal operating loss carryforwards |  | 2,100,000,000 |  |
State operating loss carryforwards |  | 2,400,000,000 |  |
Federal operation loss carryforwards, not subject to expiration |  | $ 77,000,000 |  |
Operating loss carryforwards, limitations on use |  | Pursuant to Internal Revenue Code (“IRC”) Sections 382 and 383, annual use of the Company’s federal and California net operating loss and research and development credit carryforwards may be limited in the event a cumulative change in ownership of more than 50% occurs within a three-year period. |  |
Net operating loss carryforwards | $ 216,000,000 |  |  |
Net operating loss and credit carryforwards, annual use limitation | $ 13,000,000 |  |  |
Research and development credits |  | $ 81,583,000 | $ 83,461,000 |
Undistributed earnings from its foreign subsidiaries |  | $ 0 |  |
Effective income tax rate |  | 21.00% | 35.00% | 35.00%
Decrease of deferred tax assets |  | $ 301,000,000 |  |
Decrease in valuation allowance |  | 301,000,000 |  |
Additional income tax expense or benefit |  | 0 |  |
Change in tax rate deferred tax asset and liability provisional amount |  |  | $ 301,000,000 |
Federal |  |  |  |
Income Taxes [Line Items] |  |  |  |
Research and development credits |  | $ 54,200,000 |  |
Federal research and development credits begin to expire |  | 2024 |  |
State |  |  |  |
Income Taxes [Line Items] |  |  |  |
Research and development credits |  | $ 27,400,000 |  |
Topic 606 |  |  |  |
Income Taxes [Line Items] |  |  |  |
Adjustment of deferred tax liability due to adoption of new revenue guidance |  | $ 400,000 |  |

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