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Common and Preferred Stock - Additional Information (Detail) $ / shares in Units, $ in Thousands |  |  |  |  |  |  | 3 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Dec. 19, 2018 USD ($) $ / shares shares | Apr. 05, 2018 USD ($) $ / shares shares | Feb. 28, 2018 USD ($) | Oct. 23, 2017 shares | Oct. 10, 2017 USD ($) $ / shares shares | Mar. 01, 2017 | Dec. 31, 2017 USD ($) $ / shares shares | Dec. 31, 2018 USD ($) $ / shares shares | Dec. 31, 2016 USD ($) | Dec. 13, 2017 $ / shares shares | Dec. 12, 2017 shares
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Reverse stock split, description |  |  |  |  |  |  |  | On March 1, 2017, the Company effected a 1-for-5 reverse stock split of the Company’s outstanding common stock. As a result, prior to March 1, 2017, all common stock share amounts included in these consolidated financial statements have been retroactively reduced by a factor of five, and all common stock per share amounts have been increased by a factor of five, with the exception of the Company’s common stock par value. |  |  |
Common stock, shares authorized |  |  |  |  |  |  | 280,000,000 | 280,000,000 |  | 280,000,000 | 140,000,000
Common stock, par value | $ / shares |  |  |  |  |  |  | $ 0.01 | $ 0.01 |  | $ 0.01 |
Undesignated preferred stock, shares authorized |  |  |  |  |  |  | 10,000,000 | 10,000,000 |  | 10,000,000 |
Undesignated preferred stock, par value | $ / shares |  |  |  |  |  |  | $ 0.01 | $ 0.01 |  | $ 0.01 |
Common stock, shares issued |  |  |  |  |  |  | 119,053,414 | 187,029,967 |  |  |
Common stock, shares outstanding |  |  |  |  |  |  | 119,053,414 | 187,029,967 |  |  |
Undesignated preferred stock, shares outstanding |  |  |  |  |  |  | 0 | 0 |  |  |
Amount of net proceeds from issuance of securities | $ |  |  |  |  |  |  |  |  | $ 893 |  |
At Market Issuance Sales Agreement |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of shares sold during the period |  |  |  |  |  |  |  | 230,445 |  |  |
Amount of net proceeds from issuance of securities | $ |  |  |  |  |  |  |  | $ 400 |  |  |
Purchase Agreements |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Stock purchase agreements date |  | Apr. 05, 2018 | Feb. 28, 2018 |  | Oct. 10, 2017 |  |  |  |  |  |
Placement agent fees |  |  |  |  | 5.00% |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Stock split of common stock |  |  |  |  |  | 0.2 |  |  |  |  |
Number of shares sold during the period |  |  |  | 973,236 |  |  |  |  |  |  |
Common Stock | Public Offering |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of shares sold during the period |  |  |  |  |  |  |  | 26,667,000 |  |  |
Common Stock | Underwriting Agreement with Leerink Partners LLC |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Exchange price per share | $ / shares | $ 1.50 |  |  |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities | $ | $ 37,300 |  |  |  |  |  |  |  |  |  |
Closing of Offering Date | Dec. 26, 2018 |  |  |  |  |  |  |  |  |  |
Common Stock | Underwriting Agreement with Leerink Partners LLC | Public Offering |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of shares sold during the period | 26,666,667 |  |  |  |  |  |  |  |  |  |
Common Stock | Purchase Agreements |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of shares sold during the period |  | 14,000,000 |  |  | 10,166,600 |  |  |  |  |  |
Exchange price per share | $ / shares |  | $ 2.00 |  |  | $ 6.00 |  |  |  |  |  |
Amount of net proceeds from issuance of securities | $ |  | $ 26,400 |  |  | $ 57,700 |  |  |  |  |  |
Common Stock | Charitable Foundation | Chairman of Board of Directors |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of shares sold during the period |  |  |  |  | 166,600 |  |  |  |  |  |
Common Stock | FBR Capital Markets & Co. | At Market Issuance Sales Agreement |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of shares sold during the period |  |  |  |  |  |  | 173,327 |  |  |  |
Exchange price per share | $ / shares |  |  |  |  |  |  | $ 3.15 |  |  |  |
Amount of net proceeds from issuance of securities | $ |  |  |  |  |  |  | $ 500 |  |  |  |
Common Stock | Cantor Fitzgerald | At Market Issuance Sales Agreement |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of shares sold during the period |  |  |  |  |  |  |  | 1,028,432 |  |  |
Exchange price per share | $ / shares |  |  |  |  |  |  |  | $ 2.03 |  |  |
Amount of net proceeds from issuance of securities | $ |  |  |  |  |  |  |  | $ 2,100 |  |  |
Common Stock | Cantor Fitzgerald | Contolled Equity Offering Sales Agreement | Maximum |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities | $ |  |  | $ 50,000 |  |  |  |  |  |  |  |
Warrants | Underwriting Agreement with Leerink Partners LLC |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants | $ / shares | $ 1.60 |  |  |  |  |  |  |  |  |  |
Warrants expiration, date | Dec. 26, 2019 |  |  |  |  |  |  |  |  |  |
Warrants | Underwriting Agreement with Leerink Partners LLC | Maximum |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase common stock | 26,666,667 |  |  |  |  |  |  |  |  |  |
Warrants | Purchase Agreements |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants | $ / shares |  | $ 2.38 |  |  |  |  |  |  |  |  |
Warrants expiration, date |  | Apr. 09, 2019 |  |  |  |  |  |  |  |  |
Closing of Offering Date |  | Apr. 09, 2018 |  |  |  |  |  |  |  |  |
Warrants | Purchase Agreements | Maximum |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase common stock |  | 14,000,000 |  |  |  |  |  |  |  |  |

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