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Commitments and Contingencies - Additional Information (Detail) $ / shares in Units, € in Millions |  |  |  |  |  | 3 Months Ended | 12 Months Ended |  |  |  |  |  |  |  |
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Dec. 19, 2018 USD ($) $ / shares shares | Apr. 05, 2018 USD ($) $ / shares shares | Nov. 29, 2017 USD ($) | Oct. 23, 2017 shares | May 05, 2017 USD ($) | Dec. 31, 2018 USD ($) | Jun. 30, 2018 USD ($) Vehicle | Dec. 31, 2018 USD ($) | Dec. 31, 2018 EUR (€) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2018 EUR (€) | Sep. 07, 2018 $ / shares | Sep. 06, 2018 $ / shares | Jul. 12, 2018 $ / shares | Jun. 08, 2018 $ / shares | Mar. 08, 2018 USD ($) | Apr. 18, 2017 $ / shares | Jul. 01, 2013 USD ($)
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase commitment amount under Insulin Supply Agreement | € |  |  |  |  |  |  |  |  | € 90.3 |  |  |  |  |  |  |  |  |  |
Long Term Purchase Commitment Remaining Amount | € |  |  |  |  |  |  |  |  |  |  |  | € 85.8 |  |  |  |  |  |  |
Supply Agreement expiration period |  |  |  |  |  |  |  | Dec. 31, 2024 | Dec. 31, 2024 |  |  |  |  |  |  |  |  |  |
Supply Agreement renewal period |  |  |  |  |  |  |  | 2 years | 2 years |  |  |  |  |  |  |  |  |  |
Purchase requirement amount for remaining current year | € |  |  |  |  |  |  |  |  |  |  |  | € 4.4 |  |  |  |  |  |  |
Realized currency loss |  |  |  |  |  |  |  | $ 4,468,000 |  | $ (13,641,000) | $ 3,433,000 |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities |  |  |  |  |  |  |  |  |  |  | 893,000 |  |  |  |  |  |  |  |
Operating lease rent expenses |  |  |  |  |  |  |  | $ 500,000 |  | $ 400,000 | $ 400,000 |  |  |  |  |  |  |  |
Lease Agreement with Enterprise | Vehicle Leases |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of vehicle leases | Vehicle |  |  |  |  |  |  | 100 |  |  |  |  |  |  |  |  |  |  |  |
Operating lease rent expenses |  |  |  |  |  |  | $ 83,000 |  |  |  |  |  |  |  |  |  |  |  |
Lease expiration period |  |  |  |  |  |  | 48 months |  |  |  |  |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares sold in underwritten public offering | shares |  |  |  | 973,236 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase Agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock purchase agreements date |  | Apr. 05, 2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase Agreements | Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares sold in underwritten public offering | shares |  | 14,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities |  | $ 26,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exchange price per share | $ / shares |  | $ 2.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase Agreements | Warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase of common stock | shares |  | 14,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants | $ / shares |  | $ 2.38 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Foreign Currency Hedging Transaction |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Foreign currency hedging transaction renewable period |  |  |  |  |  |  |  | 90 days | 90 days |  |  |  |  |  |  |  |  |  |
Cost of Goods Sold |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amendment fee |  |  |  |  |  | $ 2,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Other Income and Expense | Foreign Currency Hedging Transaction |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Realized currency loss |  |  |  |  |  |  |  | $ 600,000 |  |  |  |  |  |  |  |  |  |  |
Standby Letter of Credit | Vehicle Leases |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum borrowing capacity |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 500,000 |  |
Collateralized amount under letter of credit |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 500,000 |  |
Amount drawn down on letter of credit |  |  |  |  |  | 0 |  | 0 |  |  |  |  |  |  |  |  |  |  |
Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exchange price per share | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.78 | $ 2.04 | $ 1.80 | $ 1.96 |  | $ 1.15 |
Deerfield | Milestone Rights Liability | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent liability for milestone payments |  |  |  |  |  | $ 90,000,000 |  | $ 90,000,000 |  |  |  |  |  |  |  |  |  |  | $ 90,000,000
Leerink Partners LLC | Underwriting Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock purchase agreements date | Dec. 19, 2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant expiration date | Dec. 26, 2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Leerink Partners LLC | Underwriting Agreement | Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares sold in underwritten public offering | shares | 26,666,667 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities | $ 37,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exchange price per share | $ / shares | $ 1.50 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Leerink Partners LLC | Underwriting Agreement | Warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase of common stock | shares | 26,666,667 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants | $ / shares | $ 1.60 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Russell Ranch Road II LLC |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating lease rent expenses |  |  | $ 35,969 |  | $ 40,951 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of annual increase in lease payment |  |  | 3.00% |  | 3.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lease expiration date |  |  | Jan. 31, 2023 |  | Jan. 31, 2023 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lease renewal option |  |  | 5 years |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum reimbursable amount for tenant improvements |  |  | $ 56,325 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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