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Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
CASH FLOWS FROM OPERATING ACTIVITIES: |  |  |
Net (loss) income | $ (86,975,000) | $ (117,333,000) | $ 125,664,000
Adjustments to reconcile net (loss) income to net cash used in operating activities: |  |  |
Depreciation, amortization and accretion | 2,857,000 | 3,528,000 | 4,158,000
Stock-based compensation expense | 6,857,000 | 4,847,000 | 5,135,000
Change in fair value of warrant liability |  | (5,488,000) | (5,369,000)
(Gain) Loss on foreign currency translation | (4,468,000) | 13,641,000 | (3,433,000)
(Gain) Loss on extinguishment of debt | 765,000 | 1,611,000 | (72,024,000)
Interest incurred through borrowings under Sanofi Loan Facility |  |  | 4,478,000
Interest on note payable to related party | 4,488,000 | 3,782,000 | 2,901,000
Series A warrant issuance cost |  |  | 653,000
Other, net | (25,000) | 100,000 | 19,000
(Gain) loss on sale, abandonment/disposal or impairment of property and equipment | (114,000) | 203,000 | 1,259,000
Gain on purchase commitments | (10,000) | (215,000) | (2,265,000)
Write-off of inventory | 2,212,000 | 2,971,000 | 0
Changes in operating assets and liabilities: |  |  |
Accounts receivable, net | (1,339,000) | (2,487,000) | (302,000)
Receivable from Sanofi |  | 30,557,000 | (30,534,000)
Inventory | (3,152,000) | (3,297,000) | (2,331,000)
Deferred costs from commercial product sales |  | (96,000) | (309,000)
Deferred costs from collaboration |  |  | 13,539,000
Prepaid expenses and other current assets | 454,000 | 1,354,000 | (346,000)
Other assets | 200,000 | 188,000 | 361,000
Accounts payable | (1,605,000) | 3,800,000 | (12,118,000)
Accrued expenses and other current liabilities | 2,249,000 | 2,932,000 | 348,000
Deferred revenue |  | (381,000) | 3,419,000
Deferred payments from collaboration | 46,814,000 | (250,000) | (134,056,000)
Deferred sales from collaboration |  |  | (17,503,000)
Loss on purchase commitments | (6,939,000) | (4,745,000) | 40,566,000
Net cash used in operating activities | (37,731,000) | (64,778,000) | (78,090,000)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |  |
Purchase of property and equipment | (354,000) |  | (1,144,000)
Net proceeds from sale of asset held for sale |  | 16,651,000 |
Proceeds from sale of property and equipment | 120,000 | 24,000 | 17,000
Net cash provided by (used in) investing activities | (234,000) | 16,675,000 | (1,127,000)
CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |
Proceeds from direct placement of common stock | 28,000,000 | 61,000,000 | 50,000,000
Issuance cost associated with direct placement | (1,610,000) | (3,310,000) | (2,690,000)
Proceeds from issuance of common stock |  |  | 893,000
Principal payments on facility financing obligation | (5,000,000) | (4,000,000) | (5,000,000)
Payment of employment taxes related to vested restricted stock units |  | (127,000) | (165,000)
Borrowings on note payable to related party |  | 19,429,000 |
Proceeds from market price stock purchase plan | 430,000 |  |
Other | 7,000 | 24,000 |
Net cash provided by financing activities | 61,294,000 | 73,563,000 | 43,038,000
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH | 23,329,000 | 25,460,000 | (36,179,000)
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD | 48,355,000 | 22,895,000 | 59,074,000
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD | 71,684,000 | 48,355,000 | 22,895,000
SUPPLEMENTAL CASH FLOWS DISCLOSURES: |  |  |
Income taxes paid in cash | 240,000 | 51,000 |
Interest paid in cash, net of amounts capitalized | 3,759,000 | 7,728,000 | 8,991,000
NON-CASH INVESTING AND FINANCING ACTIVITIES: |  |  |
Payment of note obligations and interest through issuance of common stock | 42,912,000 | 20,593,000 |
Payment of note payable to related party through issuance of common stock | 8,160,000 |  |
Capitalization of interest on note payable to related party |  | 10,716,000 |
Non-cash construction in progress and property and equipment |  |  | 588,000
Reclassification of deferred payments from collaboration to Sanofi Loan Facility and loss share obligation |  |  | 5,174,000
Reclassification of property and equipment to asset held for sale |  |  | $ 17,294,000
Reclassification of warrant liability to additional paid-in capital |  | 1,880,000 |
Public Offering |  |  |
CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |
Proceeds from issuance of common stock | 40,000,000 |  |
Issuance costs | (2,538,000) |  |
At-the-market Issuance |  |  |
CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |
Proceeds from issuance of common stock | 2,089,000 | 564,000 |
Issuance costs | $ (84,000) | $ (17,000) |

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