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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2018
Income Tax Disclosure [Abstract] |
Loss from Continuing Operations Before Provision for Income Tax | Loss from continuing operations before provision for income tax for the Company’s domestic and international operations was as follows (in thousands):
|  | December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
US |  | $ | (84,207 | ) |  | $ | (113,679 | ) |  | $ | 129,361 |
Foreign |  |  | (2,528 | ) |  |  | (3,603 | ) |  |  | (3,697 | )
Loss before provision for income taxes |  | $ | (86,735 | ) |  | $ | (117,282 | ) |  | $ | 125,664 |
Provision for Income Taxes | The provision for income taxes consists of the following (in thousands):
|  | Year Ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Current |  |  |  |  |  |  |  |  |  |  |  |
U.S. federal |  | $ | — |  |  | $ | — |  |  | $ | — |
U.S. state |  |  | — |  |  |  | — |  |  |  | — |
Non-U.S. |  |  | 240 |  |  |  | 51 |  |  |  | — |
Total current |  |  | 240 |  |  |  | 51 |  |  |  | — |
Deferred |  |  |  |  |  |  |  |  |  |  |  |
U.S. federal |  |  | (9,164 | ) |  |  | 244,801 |  |  |  | (43,814 | )
U.S. state |  |  | (1,903 | ) |  |  | 15,398 |  |  |  | (4,311 | )
Non-U.S. |  |  | — |  |  |  | — |  |  |  | — |
Total deferred |  |  | (11,067 | ) |  |  | 260,199 |  |  |  | (48,125 | )
Valuation allowance |  |  | 11,067 |  |  |  | (260,199 | ) |  |  | 48,125 |
Total |  | $ | 240 |  |  | $ | 51 |  |  | $ | — |
Components of Net Deferred Tax Assets | Components of the net deferred tax assets as of December 31, 2018 and 2017, are as follows (in thousands):
|  | December 31, |
|  | 2018 |  |  | 2017 |
Deferred tax assets: |  |  |  |  |  |  |  |
Net operating loss carryforwards |  | $ | 524,377 |  |  | $ | 507,235 |
Research and development credits |  |  | 81,583 |  |  |  | 83,461 |
Capitalized research |  |  | 557 |  |  |  | 1,016 |
Milestone Rights |  |  | 3,521 |  |  |  | 1,908 |
Accrued expenses |  |  | 1,156 |  |  |  | 211 |
Loss on purchase commitment |  |  | 23,194 |  |  |  | 23,654 |
Non-qualified stock option expense |  |  | 2,551 |  |  |  | 7,004 |
Capitalized patent costs |  |  | 5,090 |  |  |  | 5,194 |
Other |  |  | 669 |  |  |  | 795 |
Depreciation |  |  | 22,560 |  |  |  | 23,820 |
Deferred Product Revenue & Costs |  |  | 107 |  |  |  |  |
Total net deferred tax assets |  |  | 665,365 |  |  |  | 654,298 |
Valuation allowance |  |  | (665,365 | ) |  |  | (654,298 | )
Net deferred tax assets |  | $ | — |  |  | $ | — |
Effective Income Tax Rate | The Company’s effective income tax rate differs from the statutory federal income tax rate as follows for the years ended December 31, 2018, 2017 and 2016:
|  | December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Federal tax benefit rate |  |  | 21.0 | % |  |  | 35.0 | % |  |  | 35.0 | %
Permanent items |  |  | 1.0 |  |  |  | 6.2 |  |  |  | (1.9 | )
Intercompany transfer of intellectual property |  |  | — |  |  |  | — |  |  |  | 0.9 |
Tax law changes |  |  | (0.7 | ) |  |  | (265 | ) |  |  | — |
Stock based compensation |  |  | (6.5 | ) |  |  | (5.0 | ) |  |  | — |
Tax attribute expirations |  |  | (1.6 | ) |  |  | (2.8 | ) |  |  | — |
Foreign withholding tax |  |  | (0.3 | ) |  |  | — |  |  |  | — |
Valuation allowance |  |  | (13.2 | ) |  |  | 231.6 |  |  |  | (34.0 | )
Effective income tax rate |  |  | -0.3 | % |  |  | — | % |  |  | — | %

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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319 + Details
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