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Schedule of Adoption of New Revenue Guidance Impact on Consolidated Statement of Cash Flows (Detail) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2018 | Sep. 30, 2018 | Jun. 30, 2018 | Mar. 31, 2018 | Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Cash Flows from Operating Activities |  |  |  |  |  |  |  |  |  |  |
Net loss | $ (9,747) | $ (24,168) | $ (22,675) | $ (30,385) | $ (32,784) | $ (32,886) | $ (35,339) | $ (16,324) | $ (86,975) | $ (117,333) | $ 125,664
Changes in operating assets and liabilities: |  |  |  |  |  |  |  |  |  |  |
Accounts receivable, net |  |  |  |  |  |  |  |  | (1,339) | (2,487) | (302)
Deferred costs from commercial product sales |  |  |  |  |  |  |  |  |  | 96 | 309
Accrued expenses and other current liabilities |  |  |  |  |  |  |  |  | 2,249 | 2,932 | 348
Deferred revenue, net |  |  |  |  |  |  |  |  |  | $ (381) | $ 3,419
Cash (used in) provided by operating activities |  |  |  |  |  |  |  |  | (37,731) |  |
Adjustments | Accounting Standards Update 2014-09 |  |  |  |  |  |  |  |  |  |  |
Cash Flows from Operating Activities |  |  |  |  |  |  |  |  |  |  |
Net loss |  |  |  |  |  |  |  |  | (267) |  |
Changes in operating assets and liabilities: |  |  |  |  |  |  |  |  |  |  |
Accounts receivable, net |  |  |  |  |  |  |  |  | 2,567 |  |
Deferred costs from commercial product sales |  |  |  |  |  |  |  |  | 470 |  |
Accrued expenses and other current liabilities |  |  |  |  |  |  |  |  | (751) |  |
Deferred revenue, net |  |  |  |  |  |  |  |  | (899) |  |
Cash (used in) provided by operating activities |  |  |  |  |  |  |  |  | 1,120 |  |
Balances Without Adoption of Topic 606 | Accounting Standards Update 2014-09 |  |  |  |  |  |  |  |  |  |  |
Cash Flows from Operating Activities |  |  |  |  |  |  |  |  |  |  |
Net loss |  |  |  |  |  |  |  |  | (87,242) |  |
Changes in operating assets and liabilities: |  |  |  |  |  |  |  |  |  |  |
Accounts receivable, net |  |  |  |  |  |  |  |  | 1,228 |  |
Deferred costs from commercial product sales |  |  |  |  |  |  |  |  | 470 |  |
Accrued expenses and other current liabilities |  |  |  |  |  |  |  |  | 1,498 |  |
Deferred revenue, net |  |  |  |  |  |  |  |  | (899) |  |
Cash (used in) provided by operating activities |  |  |  |  |  |  |  |  | $ (36,611) |  |

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