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Consolidated Statements of Stockholders' Deficit - USD ($) $ in Thousands | Total | At-the-market Placement | Public Offering | Note Payable to Related Party | Facility Financing Obligation | Senior Convertible Notes | Common Stock | Common Stock At-the-market Placement | Common Stock Public Offering | Common Stock Note Payable to Related Party | Common Stock Facility Financing Obligation | Common Stock Senior Convertible Notes | Additional Paid-in Capital | Additional Paid-in Capital At-the-market Placement | Additional Paid-in Capital Public Offering | Additional Paid-in Capital Note Payable to Related Party | Additional Paid-in Capital Facility Financing Obligation | Additional Paid-in Capital Senior Convertible Notes | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
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Beginning Balance at Dec. 31, 2015 | $ (350,329) |  |  |  |  |  | $ 857 |  |  |  |  |  | $ 2,512,063 |  |  |  |  |  | $ (20) | $ (2,863,229)
Beginning Balance (in shares) at Dec. 31, 2015 |  |  |  |  |  |  | 85,735,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of stock options | 467 |  |  |  |  |  | $ 1 |  |  |  |  |  | 466 |  |  |  |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  |  | 55,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common shares from the release of restricted stock units | 0 |  |  |  |  |  | $ 1 |  |  |  |  |  | (1) |  |  |  |  |  |  |
Issuance of common shares from the release of restricted stock units (in shares) |  |  |  |  |  |  | 131,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | 426 |  |  |  |  |  | $ 1 |  |  |  |  |  | 425 |  |  |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan (in shares) |  |  |  |  |  |  | 51,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 5,135 |  |  |  |  |  |  |  |  |  |  |  | 5,135 |  |  |  |  |  |  |
Restricted stock units taxes paid in cash | (165) |  |  |  |  |  |  |  |  |  |  |  | (165) |  |  |  |  |  |  |
Issuance of direct placement — common stock and warrants | 50,000 |  |  |  |  |  | $ 97 |  |  |  |  |  | 49,903 |  |  |  |  |  |  |
Issuance of direct placement - common stock and warrants (in shares) |  |  |  |  |  |  | 9,709,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance costs associated with direct placement | (2,037) |  |  |  |  |  |  |  |  |  |  |  | (2,037) |  |  |  |  |  |  |
Proceeds allocated to warrant liabilities | (12,750) |  |  |  |  |  |  |  |  |  |  |  | (12,750) |  |  |  |  |  |  |
Cumulative translation (loss) gain | (4) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (4) |
Net (loss) income | 125,664 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 125,664
Ending Balance at Dec. 31, 2016 | (183,593) |  |  |  |  |  | $ 957 |  |  |  |  |  | 2,553,039 |  |  |  |  |  | (24) | (2,737,565)
Ending Balance (in shares) at Dec. 31, 2016 |  |  |  |  |  |  | 95,681,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of stock options | 24 |  |  |  |  |  |  |  |  |  |  |  | 24 |  |  |  |  |  |  |
Exercise of stock options (in shares) |  |  |  |  |  |  | 5,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common shares from the release of restricted stock units | 1 |  |  |  |  |  | $ 2 |  |  |  |  |  | (1) |  |  |  |  |  |  |
Issuance of common shares from the release of restricted stock units (in shares) |  |  |  |  |  |  | 135,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | 236 |  |  |  |  |  | $ 1 |  |  |  |  |  | 235 |  |  |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan (in shares) |  |  |  |  |  |  | 103,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 4,847 |  |  |  |  |  |  |  |  |  |  |  | 4,847 |  |  |  |  |  |  |
Restricted stock units taxes paid in cash | (127) |  |  |  |  |  |  |  |  |  |  |  | (127) |  |  |  |  |  |  |
Issuance of shares pursuant to conversion notes | 21,099 |  |  |  |  |  | $ 115 |  |  |  |  |  | 20,984 |  |  |  |  |  |  |
Issuance of shares pursuant to conversion notes (in shares) |  |  |  |  |  |  | 11,496,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of direct placement — common stock | 61,000 |  |  |  |  |  | $ 102 |  |  |  |  |  | 60,898 |  |  |  |  |  |  |
Issuance of direct placement — common stock (in shares) |  |  |  |  |  |  | 10,167,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance costs associated with direct placement | (3,310) |  |  |  |  |  |  |  |  |  |  |  | (3,310) |  |  |  |  |  |  |
Issuance of stock |  | $ 564 |  |  |  |  |  | $ 2 |  |  |  |  |  | $ 562 |  |  |  |  |  |
Issuance of at-the-market placement (in shares) |  |  |  |  |  |  |  | 173,000 |  |  |  |  |  |  |  |  |  |  |  |
Issuance costs associated with at-the-market placement | (17) |  |  |  |  |  |  |  |  |  |  |  | (17) |  |  |  |  |  |  |
Reclassification of warrant liability to equity | 1,893 |  |  |  |  |  | $ 13 |  |  |  |  |  | 1,880 |  |  |  |  |  |  |
Reclassification of warrant liability to equity (in shares) |  |  |  |  |  |  | 1,293,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization of shelf fees | (22) |  |  |  |  |  |  |  |  |  |  |  | (22) |  |  |  |  |  |  |
Cumulative translation (loss) gain | 6 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6 |
Net (loss) income | (117,333) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (117,333)
Ending Balance at Dec. 31, 2017 | (214,732) |  |  |  |  |  | $ 1,192 |  |  |  |  |  | 2,638,992 |  |  |  |  |  | (18) | (2,854,898)
Ending Balance (in shares) at Dec. 31, 2017 |  |  |  |  |  |  | 119,053,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of stock options | $ 7 |  |  |  |  |  |  |  |  |  |  |  | 7 |  |  |  |  |  |  |
Exercise of stock options (in shares) | 6,880 |  |  |  |  |  | 7,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common shares from the release of restricted stock units | $ 1 |  |  |  |  |  | $ 2 |  |  |  |  |  | (1) |  |  |  |  |  |  |
Issuance of common shares from the release of restricted stock units (in shares) |  |  |  |  |  |  | 193,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan | 345 |  |  |  |  |  | $ 3 |  |  |  |  |  | 342 |  |  |  |  |  |  |
Issuance of common shares under Employee Stock Purchase Plan (in shares) |  |  |  |  |  |  | 400,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 6,857 |  |  |  |  |  |  |  |  |  |  |  | 6,857 |  |  |  |  |  |  |
Issuance of shares pursuant to conversion notes |  |  |  | $ 8,160 | $ 38,128 | $ 4,980 |  |  |  | $ 30 | $ 197 | $ 27 |  |  |  | $ 8,130 | $ 37,931 | $ 4,953 |  |
Issuance of shares pursuant to conversion notes (in shares) |  |  |  |  |  |  |  |  |  | 3,000,000 | 19,726,000 | 2,726,000 |  |  |  |  |  |  |  |
Issuance of direct placement — common stock | 28,000 |  |  |  |  |  | $ 140 |  |  |  |  |  | 27,860 |  |  |  |  |  |  |
Issuance of direct placement — common stock (in shares) |  |  |  |  |  |  | 14,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance costs associated with direct placement | (1,610) |  |  |  |  |  |  |  |  |  |  |  | (1,610) |  |  |  |  |  |  |
Issuance cost associated with public offering | (2,538) |  |  |  |  |  |  |  |  |  |  |  | (2,538) |  |  |  |  |  |  |
Issuance of stock |  | $ 2,089 | $ 40,000 |  |  |  |  | $ 10 | $ 267 |  |  |  |  | $ 2,079 | $ 39,733 |  |  |  |  |
Issuance of at-the-market placement (in shares) |  |  |  |  |  |  |  | 1,028,000 | 26,667,000 |  |  |  |  |  |  |  |  |  |  |
Issuance costs associated with at-the-market placement | (84) |  |  |  |  |  |  |  |  |  |  |  | (84) |  |  |  |  |  |  |
Issuance of shares under Market Price Stock Purchase Plan | 430 |  |  |  |  |  | $ 2 |  |  |  |  |  | 428 |  |  |  |  |  |  |
Issuance of shares under Market Price Stock Purchase Plan (in shares) |  |  |  |  |  |  | 230,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization of shelf fees | (12) |  |  |  |  |  |  |  |  |  |  |  | (12) |  |  |  |  |  |  |
Cumulative translation (loss) gain | (1) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (1) |
Adjustment to adopt ASU 2014-09 (Topic 606) | Topic 606 | 1,873 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,873
Net (loss) income | (86,975) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (86,975)
Ending Balance at Dec. 31, 2018 | $ (175,082) |  |  |  |  |  | $ 1,870 |  |  |  |  |  | $ 2,763,067 |  |  |  |  |  | $ (19) | $ (2,940,000)
Ending Balance (in shares) at Dec. 31, 2018 |  |  |  |  |  |  | 187,030,000 |  |  |  |  |  |  |  |  |  |  |  |  |

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