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Components of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 524,377 | $ 507,235
Research and development credits | 81,583 | 83,461
Capitalized research | 557 | 1,016
Milestone Rights | 3,521 | 1,908
Accrued expenses | 1,156 | 211
Loss on purchase commitment | 23,194 | 23,654
Non-qualified stock option expense | 2,551 | 7,004
Capitalized patent costs | 5,090 | 5,194
Other | 669 | 795
Depreciation | 22,560 | 23,820
Deferred Product Revenue & Costs | 107 | 0
Total net deferred tax assets | 665,365 | 654,298
Valuation allowance | (665,365) | (654,298)
Net deferred tax assets | $ 0 | $ 0

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