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Schedule of Revenue from Collaborations and Services (Detail) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 31, 2019 | Mar. 31, 2018
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenues | $ 17,448 | $ 3,465
Research Agreement | United Therapeutics Corporation |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenues | 4,700 |
Collaboration and License Agreement | United Therapeutics Corporation |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenues | 7,600 |
Collaborations and services |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenues | 12,372 | 63
Collaborations and services | License Agreement | United Therapeutics Corporation |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenues | 7,615 |
Collaborations and services | Research Agreement | United Therapeutics Corporation |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenues | 4,658 |
Collaborations and services | Collaboration and License Agreement | Receptor |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenues | 62 | $ 63
Collaborations and services | License and Distribution Agreement | Cipla Ltd |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenues | $ 37 |

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