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Condensed Consolidated Statements of Stockholders' Deficit - USD ($)
shares in Thousands, $ in Thousands
Total
Senior Convertible Notes
Facility Financing Obligation
Related Party Notes
At-the-market Issuance
Common Stock
Common Stock
Senior Convertible Notes
Common Stock
Facility Financing Obligation
Common Stock
Related Party Notes
Common Stock
At-the-market Issuance
Additional Paid-in Capital
Additional Paid-in Capital
Senior Convertible Notes
Additional Paid-in Capital
Facility Financing Obligation
Additional Paid-in Capital
Related Party Notes
Additional Paid-in Capital
At-the-market Issuance
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Beginning Balance at Dec. 31, 2017 $ (214,733)         $ 1,191         $ 2,638,992         $ (18) $ (2,854,898)
Beginning Balance (in shares) at Dec. 31, 2017           119,053                      
Adjustment to adopt ASU 2016-09 | Topic 718 1,873                               1,873
Issuance of common shares from the release of restricted stock units (81)         $ 1         (82)            
Issuance of common shares from the release of restricted stock units (in shares)           60                      
Issuance of common shares under Employee Stock Purchase Plan 1         $ 1                      
Issuance of common shares under Employee Stock Purchase Plan (in shares)           137                      
Stock-based compensation expense 1,943                   1,943            
Issuance of shares pursuant to conversion notes     $ 9,407 $ 8,160       $ 35 $ 30       $ 9,372 $ 8,130      
Issuance of shares pursuant to conversion notes (in shares)               3,549 3,000                
Cumulative translation gain 3                             3  
Amortization of shelf fees (5)                   (5)            
Issuance of at-the-market placement         $ 634         $ 2         $ 632    
Issuance of at-the-market placement (in shares)                   214              
Issuance costs associated with at-the- market placement (25)                   (25)            
Net loss (30,385)                               (30,385)
Ending Balance at Mar. 31, 2018 (223,208)         $ 1,260         2,658,957         (15) (2,883,410)
Ending Balance (in shares) at Mar. 31, 2018           126,013                      
Beginning Balance at Dec. 31, 2018 (175,082)         $ 1,870         2,763,067         (19) (2,940,000)
Beginning Balance (in shares) at Dec. 31, 2018           187,030                      
Exercise of stock options 3                   3            
Exercise of stock options (in shares)           3                      
Issuance of common shares from the release of restricted stock units (1)         $ 1         (2)            
Issuance of common shares from the release of restricted stock units (in shares)           63                      
Issuance of common shares under Employee Stock Purchase Plan 317         $ 3         314            
Issuance of common shares under Employee Stock Purchase Plan (in shares)           296                      
Stock-based compensation expense 999                   999            
Restricted stock unit award 105                   105            
Issuance of shares pursuant to conversion notes   $ 538         $ 4         $ 534          
Issuance of shares pursuant to conversion notes (in shares)             386                    
Net loss (14,883)                               (14,883)
Ending Balance at Mar. 31, 2019 $ (188,004)         $ 1,878         $ 2,765,020         $ (19) $ (2,954,883)
Ending Balance (in shares) at Mar. 31, 2019           187,778