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Income Taxes - Additional Information (Detail) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Aug. 31, 2004 | Dec. 31, 2019 | Dec. 31, 2018
Income Taxes [Line Items] |  |  |
Provision for income taxes |  | $ 0 | $ 240,000
Valuation allowance of deferred tax asset |  | 670,617,000 | 665,365,000
Change in the valuation allowance |  | 5,252,000 | 11,067,000
Federal operating loss carryforwards |  | 2,100,000,000 |
State operating loss carryforwards |  | 1,300,000,000 |
Federal operation loss carryforwards, not subject to expiration |  | $ 117,800,000 |
Operating loss carryforwards, limitations on use |  | Pursuant to Internal Revenue Code (“IRC”) Sections 382 and 383, annual use of the Company’s federal and state net operating loss and research and development credit carryforwards may be limited in the event a cumulative change in ownership of more than 50% occurs within a three-year period. |
Net operating loss carryforwards | $ 216,000,000 |  |
Net operating loss and credit carryforwards, annual use limitation | $ 13,000,000 |  |
Research and development credits |  | $ 80,488,000 | 81,583,000
Research and development credits begin to expire |  | 2020 |
Undistributed earnings from its foreign subsidiaries |  | $ 0 |
Adjustment of deferred tax liability due to adoption of new leases guidance |  | 958,000 |
Adjustment of deferred tax asset due to adoption of new leases guidance |  | 671,575,000 | $ 665,365,000
(“ASC”) Topic 842 – Leases |  |  |
Income Taxes [Line Items] |  |  |
Adjustment of deferred tax liability due to adoption of new leases guidance |  | 700,000 |
Adjustment of deferred tax asset due to adoption of new leases guidance |  | 700,000 |
Federal |  |  |
Income Taxes [Line Items] |  |  |
Research and development credits |  | $ 54,200,000 |
Research and development credits begin to expire |  | 2024 |
New Jersey |  |  |
Income Taxes [Line Items] |  |  |
Research and development credits begin to expire |  | 2020 |
Connecticut |  |  |
Income Taxes [Line Items] |  |  |
Research and development credits |  | $ 900,000 |
Research and development credits not expire |  | 15,700,000 |
State |  |  |
Income Taxes [Line Items] |  |  |
Research and development credits |  | $ 26,300,000 |

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