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Components of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2019 | Dec. 31, 2018
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 531,970 | $ 524,377
Research and development credits | 80,488 | 81,583
Capitalized research | 44 | 557
Milestone Rights | 1,528 | 3,521
Accrued expenses | 1,951 | 1,156
Loss on purchase commitment | 22,167 | 23,194
Non-qualified stock option expense | 3,128 | 2,551
Capitalized patent costs | 4,964 | 5,090
Other | 147 | 669
Lease liability | 827 |
Interest expense limitation | 1,167 |
Depreciation | 21,132 | 22,560
Deferred Product Revenue & Costs | 2,062 | 107
Total net deferred tax assets | 671,575 | 665,365
Valuation allowance | (670,617) | $ (665,365)
Net deferred tax assets | 958 |
Deferred tax liabilities: |  |
Right of use asset | (751) |
Other prepaids | (207) |
Total deferred tax liabilities | $ (958) |

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