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Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018
CASH FLOWS FROM OPERATING ACTIVITIES: |  |
Net loss | $ (51,903,000) | $ (86,975,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Payment-in-kind interest on promissory notes | (32,822,000) |
Interest expense on promissory notes | 4,712,000 | 4,488,000
Stock-based compensation expense | 6,203,000 | 6,857,000
Gain on foreign currency translation | (1,913,000) | (4,468,000)
(Gain) loss on extinguishment of debt | (3,529,000) | 765,000
Amortization of right-of-use assets | 1,182,000 |
Depreciation, amortization and accretion | 972,000 | 2,857,000
Loss on warrant transactions | 868,000 |
Gain on sale, abandonment/disposal or impairment of property and equipment |  | (114,000)
Write-off of inventory | 0 | 2,212,000
Other, net | 107,000 | (35,000)
Changes in operating assets and liabilities: |  |
Accounts receivable, net | 504,000 | (1,339,000)
Inventory | (558,000) | (3,152,000)
Prepaid expenses and other current assets | (333,000) | 454,000
Other assets | (549,000) | 200,000
Accounts payable | (593,000) | (1,605,000)
Accrued expenses and other current liabilities | 3,498,000 | 2,249,000
Deferred revenue | (6,717,000) | 46,814,000
Recognized loss on purchase commitments | (4,395,000) | (6,939,000)
Operating lease liabilities | (1,672,000) |
Accrued interest on Mann Group promissory notes | (1,545,000) |
Net cash used in operating activities | (88,483,000) | (37,731,000)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |
Purchase of treasury bills | (44,971,000) |
Proceeds from sale of treasury bills | 24,993,000 |
Purchase of property and equipment | (2,565,000) | (354,000)
Proceeds from sale of property and equipment |  | 120,000
Purchase of limited liability company ownership interest | (300,000) |
Net cash used in investing activities | (22,843,000) | (234,000)
CASH FLOWS FROM FINANCING ACTIVITIES: |  |
Proceeds from promissory notes | 70,051,000 |
Proceeds from MidCap Credit Facility | 40,000,000 |
Proceeds from senior convertible notes | 9,910,000 |
Principal payments on Mann Group promissory notes | (38,264,000) |
Principal payments on senior convertible notes | (11,081,000) |
Principal payments on facility financing obligation | (6,920,000) | (5,000,000)
Issuance of common stock from the exercise of warrants | 5,900,000 |
Proceeds from public offering |  | 40,000,000
Milestone payment | (1,643,000) |
Issuance cost associated with MidCap Credit Facility | (886,000) |
Issuance cost associated with Mann Group promissory notes | (33,000) |
Repurchase of warrants | (433,000) |
Exercise of stock options | 124,000 |
Proceeds from direct placement |  | 28,000,000
Proceeds from market price stock purchase plan |  | 430,000
Issuance cost associated with direct placement |  | (1,610,000)
Other |  | 7,000
Net cash provided by financing activities | 69,864,000 | 61,294,000
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH | (41,462,000) | 23,329,000
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD | 71,684,000 | 48,355,000
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD | 30,222,000 | 71,684,000
SUPPLEMENTAL CASH FLOWS DISCLOSURES: |  |
Interest paid in cash, net of amounts capitalized | 1,757,000 | 3,759,000
Income taxes paid in cash |  | 240,000
NON-CASH INVESTING AND FINANCING ACTIVITIES: |  |
Payment on promissory notes through issuance of common stock | 8,000,000 | 8,160,000
Addition of right-of-use assets upon adoption of new lease guidance | 5,192,000 |
Payment of facility obligation through common stock issuance | 4,575,000 | 37,912,000
Payment of senior convertible notes through common stock issuance | 4,500,000 | 5,000,000
Payment of interest on senior convertible notes through common stock issuance | 1,075,000 |
Common stock issuance to settle employee stock purchase plan liability | 656,000 |
Issuance of warrants associated with MidCap Credit Facility | 1,854,000 |
Public Offering |  |
CASH FLOWS FROM FINANCING ACTIVITIES: |  |
Issuance costs |  | (2,538,000)
At The Market Issuance |  |
CASH FLOWS FROM FINANCING ACTIVITIES: |  |
Proceeds from public offering | 3,199,000 | 2,089,000
Issuance costs | $ (60,000) | $ (84,000)

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