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v3.19.3.a.u2

Common and Preferred Stock - Additional Information (Detail) - USD ($) |  |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Dec. 26, 2019 | Dec. 23, 2019 | Jul. 31, 2019 | Dec. 31, 2018 | Apr. 30, 2018 | Feb. 28, 2018 | Dec. 31, 2019 | Dec. 31, 2018
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Common stock, shares authorized |  |  |  | 280,000,000 |  |  | 280,000,000 | 280,000,000
Common stock, par value |  |  |  | $ 0.01 |  |  | $ 0.01 | $ 0.01
Undesignated preferred stock, shares authorized |  |  |  | 10,000,000 |  |  | 10,000,000 | 10,000,000
Undesignated preferred stock, par value |  |  |  | $ 0.01 |  |  | $ 0.01 | $ 0.01
Common stock, shares issued |  |  |  | 187,029,967 |  |  | 211,787,573 | 187,029,967
Common stock, shares outstanding |  |  |  | 187,029,967 |  |  | 211,787,573 | 187,029,967
Undesignated preferred stock, shares outstanding |  |  |  | 0 |  |  | 0 | 0
Other expense |  |  |  |  |  |  | $ (7,306,000) | $ (10,140,000)
Common Stock | Public Offering |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Number of shares sold during the period |  |  |  |  |  |  |  | 26,667,000
Purchase Agreements |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Stock purchase agreements date |  |  |  |  | Apr. 30, 2018 | Feb. 28, 2018 |  |
Purchase Agreements | Common Stock |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities |  |  |  |  | $ 26,400,000 |  |  |
Number of shares sold during the period |  |  |  |  | 14,000,000 |  |  |
Exchange price per share |  |  |  |  | $ 2.00 |  |  |
Purchase Agreements | Warrants |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Exercise price of warrants |  |  |  |  | $ 2.38 |  |  |
Warrants expiration, date |  |  |  |  | Apr. 09, 2019 |  |  |
Closing of Offering Date |  |  |  |  | Apr. 09, 2018 |  |  |
Purchase Agreements | Warrants | Maximum |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Warrants to purchase common stock |  |  |  |  | 14,000,000 |  |  |
Contolled Equity Offering Sales Agreement | Cantor Fitzgerald | Common Stock | Maximum |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities |  |  |  |  |  | $ 50,000,000 |  |
At Market Issuance Sales Agreement |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities |  |  |  |  |  |  | $ 0 | $ 400,000
Number of shares sold during the period |  |  |  |  |  |  | 0 | 230,445
At Market Issuance Sales Agreement | Cantor Fitzgerald | Common Stock |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities |  |  |  |  |  |  | $ 3,200,000 | $ 2,100,000
Number of shares sold during the period |  |  |  |  |  |  | 2,584,964 | 1,028,432
Exchange price per share |  |  |  | $ 2.03 |  |  | $ 1.24 | $ 2.03
Underwriting Agreement with Leerink Partners LLC |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Stock purchase agreements date |  |  |  | Dec. 31, 2018 |  |  |  |
Exercise price of warrants |  | $ 1.311 |  |  |  |  |  |
Warrants expiration, date |  | Jun. 26, 2020 |  | Dec. 26, 2019 |  |  |  |
Warrants modified |  | 11,750,000 |  |  |  |  |  |
Warrants exercised |  | 4,500,000 |  |  |  |  |  |
Warrants expired unexercised | 11,583,333 |  |  |  |  |  |  |
Remaining warrants available for purchase |  |  |  |  |  |  | 7,250,000 |
Underwriting Agreement with Leerink Partners LLC | Minimum |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Warrants exercised |  | 4,500,000 |  |  |  |  |  |
Underwriting Agreement with Leerink Partners LLC | Common Stock |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities |  |  |  | $ 37,300,000 |  |  |  |
Exchange price per share |  |  |  | $ 1.50 |  |  |  | 1.50
Underwriting Agreement with Leerink Partners LLC | Common Stock | Public Offering |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Number of shares sold during the period |  |  |  | 26,666,667 |  |  |  |
Underwriting Agreement with Leerink Partners LLC | Warrants |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities |  | $ 5,900,000 |  |  |  |  |  |
Exercise price of warrants |  |  |  | $ 1.60 |  |  | $ 1.60 | $ 1.60
Closing of Offering Date |  |  |  |  |  |  | Jun. 26, 2020 |
Repurchase of common stock , shares |  |  | 3,333,334 |  |  |  |  |
Repurchase of common stock , value |  |  | $ 400,000 |  |  |  |  |
Additional paid-in capital |  | $ 700,000 | 200,000 |  |  |  |  |
Other expense |  |  | $ 200,000 |  |  |  |  |
Underwriting Agreement with Leerink Partners LLC | Warrants | Maximum |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Warrants to purchase common stock |  |  |  | 26,666,667 |  |  |  | 26,666,667

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