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Collaboration and Licensing Arrangements - Additional Information (Detail 1) - USD ($) $ in Millions | Dec. 31, 2019 | May 31, 2018 | Dec. 31, 2016
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Collaboration and License Agreement | Receptor | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date: 2017-01-01 |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Deferred revenue recognition period |  |  | 4 years
Deferred revenue - nonrefundable license fee |  |  | $ 1.0
Collaboration and License Agreement | United Therapeutics Corporation |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Deferred revenue - nonrefundable license fee | $ 101.4 |  |
Collaboration and License Agreement | United Therapeutics Corporation | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date: 2018-10-01 |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Deferred revenue recognition period | 39 months |  |
License and Distribution Agreement | Cipla Ltd | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date: 2018-06-01 |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Deferred revenue recognition period |  | 15 years |
Deferred revenue - nonrefundable license fee |  | $ 2.2 |

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