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Common and Preferred Stock - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands |  |  |  |  |  |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Feb. 25, 2021 | Jan. 01, 2021 | Dec. 07, 2020 | Oct. 09, 2020 | Jun. 24, 2020 | Dec. 26, 2019 | Dec. 23, 2019 | Feb. 28, 2021 | Jan. 31, 2021 | Dec. 31, 2020 | Jul. 31, 2019 | Dec. 31, 2018 | Feb. 28, 2018 | Dec. 31, 2020 | Dec. 31, 2020 | Dec. 31, 2019
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares authorized |  |  |  |  |  |  |  |  |  | 400,000,000 |  |  |  | 400,000,000 | 400,000,000 | 280,000,000
Common stock, par value |  |  |  |  |  |  |  |  |  | $ 0.01 |  |  |  | $ 0.01 | $ 0.01 | $ 0.01
Undesignated preferred stock, shares authorized |  |  |  |  |  |  |  |  |  | 10,000,000 |  |  |  | 10,000,000 | 10,000,000 | 10,000,000
Undesignated preferred stock, par value |  |  |  |  |  |  |  |  |  | $ 0.01 |  |  |  | $ 0.01 | $ 0.01 | $ 0.01
Common stock, shares issued |  |  |  |  |  |  |  |  |  | 242,117,089 |  |  |  | 242,117,089 | 242,117,089 | 211,787,573
Common stock, shares outstanding |  |  |  |  |  |  |  |  |  | 242,117,089 |  |  |  | 242,117,089 | 242,117,089 | 211,787,573
Undesignated preferred stock, shares outstanding |  |  |  |  |  |  |  |  |  | 0 |  |  |  | 0 | 0 | 0
Other expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (9,545) | $ (7,306)
QrumPharma |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of common stock issued |  |  | 3,067,179 |  |  |  |  |  |  | 3,067,179 |  |  |  |  |  |
MidCap Credit Facility |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase of common stock |  |  |  |  |  |  |  |  |  | 111,853 |  |  |  | 111,853 | 111,853 |
Warrants expiration date |  |  |  |  |  |  |  |  |  | Dec. 01, 2027 |  |  |  | Dec. 01, 2027 | Dec. 01, 2027 |
Convertible Promissory Note | The Mann Group |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock to note holders |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,800,000 |  |
Conversion of notes accrued interest to common shares, value |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 3,000 |  |
Conversion of notes accrued interest to common shares |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,200,000 |  |
Conversion of notes to common shares, value |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 7,000 |  |
Convertible Promissory Note | Subsequent Event | The Mann Group |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock to note holders | 4,000,000.0 |  |  |  |  |  |  |  | 4,000,000.0 |  |  |  |  |  |  |
Conversion of notes accrued interest to common shares, value |  |  |  |  |  |  |  |  | $ 400 |  |  |  |  |  |  |
Conversion of notes to common shares, value | $ 9,600 |  |  |  |  |  |  |  | $ 9,600 |  |  |  |  |  |  |
2024 Convertible Notes | Scenario Forecast |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock to note holders |  |  |  |  |  |  |  | 1,700,000 |  |  |  |  |  |  |  |
Conversion of notes to common shares, value |  |  |  |  |  |  |  | $ 5,000 |  |  |  |  |  |  |  |
2024 Convertible Notes | Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock to note holders |  | 1,666,667 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of notes to common shares, value |  | $ 5,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock | June 2020 Note |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock to note holders |  |  |  |  | 1,235,094 |  |  |  |  |  |  |  |  |  |  |
Common Stock | December 2020 Note |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock to note holders |  |  |  | 1,377,356 |  |  |  |  |  |  |  |  |  |  |  |
Contolled Equity Offering Sales Agreement | Cantor Fitzgerald |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock purchase agreements date |  |  |  |  |  |  |  |  |  |  |  |  | Feb. 28, 2018 |  |  |
Contolled Equity Offering Sales Agreement | Cantor Fitzgerald | Common Stock | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities |  |  |  |  |  |  |  |  |  |  |  |  | $ 50,000 |  |  |
At Market Issuance Sales Agreement | Cantor Fitzgerald | Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 23,500 | $ 3,200
Number of shares sold during the period |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 11,851,566 | 2,584,964
Exchange price per share |  |  |  |  |  |  |  |  |  | $ 1.99 |  |  |  | $ 1.99 | $ 1.99 | $ 1.24
Underwriting Agreement with Leerink Partners LLC |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock purchase agreements date |  |  |  |  |  |  |  |  |  |  |  | Dec. 31, 2018 |  |  |  |
Exercise price of warrants |  |  |  |  |  |  | $ 1.311 |  |  |  |  |  |  |  |  |
Warrants expiration, date |  |  |  |  |  |  | Jun. 26, 2020 |  |  |  |  | Dec. 26, 2019 |  |  |  |
Warrants modified |  |  |  |  |  |  | 11,750,000 |  |  |  |  |  |  |  |  |
Warrants exercised |  |  |  |  |  |  | 4,500,000 |  |  |  |  |  |  |  |  |
Warrants expired unexercised |  |  |  |  |  | 11,583,333 |  |  |  |  |  |  |  |  |  |
Remaining warrants available for purchase |  |  |  |  |  | 7,250,000 |  |  |  |  |  |  |  |  | 7,250,000 |
Underwriting Agreement with Leerink Partners LLC | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercised |  |  |  |  |  |  | 4,500,000 |  |  |  |  |  |  |  |  |
Underwriting Agreement with Leerink Partners LLC | Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities |  |  |  |  |  |  |  |  |  |  |  | $ 37,300 |  |  |  |
Exchange price per share |  |  |  |  |  |  |  |  |  |  |  | $ 1.50 |  |  |  |
Underwriting Agreement with Leerink Partners LLC | Common Stock | Initial Public Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares sold during the period |  |  |  |  |  |  |  |  |  |  |  | 26,666,667 |  |  |  |
Underwriting Agreement with Leerink Partners LLC | Warrant |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount of net proceeds from issuance of securities |  |  |  |  |  |  | $ 5,900 |  |  |  |  |  |  |  |  |
Exercise price of warrants |  |  |  |  |  | $ 1.60 |  |  |  | $ 1.60 |  | $ 1.60 |  | $ 1.60 | $ 1.60 |
Repurchase of common stock , shares |  |  |  |  |  |  |  |  |  |  | 3,333,334 |  |  |  |  |
Repurchase of common stock , value |  |  |  |  |  |  |  |  |  |  | $ 400 |  |  |  |  |
Additional paid-in capital |  |  |  |  |  |  | $ 700 |  |  |  | 200 |  |  |  |  |
Other expense |  |  |  |  |  |  |  |  |  |  | $ 200 |  |  |  |  |
Remained available warrants expiration period |  |  |  |  |  |  |  |  |  |  |  | 2020-06 |  |  |  |
Underwriting Agreement with Leerink Partners LLC | Warrant | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase of common stock |  |  |  |  |  |  |  |  |  |  |  | 26,666,667 |  |  |  |

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