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Components of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 533,448 | $ 531,970
Research and development credits | 79,455 | 80,488
Capitalized research |  | 44
Milestone Rights | 1,547 | 1,528
Accrued expenses | 1,436 | 1,951
Loss on purchase commitment | 23,864 | 22,167
Non-qualified stock option expense | 3,766 | 3,128
Capitalized patent costs | 5,273 | 4,964
Other | 2,093 | 147
Lease liability | 559 | 827
Interest expense limitation | 2,460 | 1,167
Depreciation | 20,735 | 21,132
Deferred Product Revenue & Costs | 1,569 | 2,062
Total net deferred tax assets | 676,205 | 671,575
Valuation allowance | (675,463) | (670,617)
Net deferred tax assets | 742 | 958
Deferred tax liabilities: |  |
Right of use asset | (510) | (751)
Other prepaids | (232) | (207)
Total deferred tax liabilities | $ (742) | $ (958)

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