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Collaboration, Licensing and Other Arrangements - Additional Information (Detail) - USD ($) | 1 Months Ended | 3 Months Ended | 12 Months Ended | 20 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Dec. 31, 2020 | Sep. 30, 2019 | May 31, 2018 | Sep. 30, 2020 | Jun. 30, 2019 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018 | Nov. 30, 2020 | Oct. 16, 2018 | Sep. 30, 2018
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue' collaborations and services |  |  |  |  |  | $ 65,144,000 | $ 63,038,000 |  |  |  |
Deferred revenue | $ 34,937,000 |  |  |  |  | 34,937,000 | 40,847,000 | $ 47,565,000 |  |  |
Deferred revenue - current | 33,275,000 |  |  |  |  | 33,275,000 | 32,503,000 |  |  |  |
Deferred revenue - long term | 1,662,000 |  |  |  |  | 1,662,000 | 8,344,000 |  |  |  |
Collaborations and services |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue' collaborations and services |  |  |  |  |  | 32,820,000 | 37,734,000 |  |  |  |
Commercial product sales |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue' collaborations and services |  |  |  |  |  | 32,324,000 | 25,304,000 |  |  |  |
Collaboration and License Agreement | United Therapeutics Corporation |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Upfront payment received |  |  |  |  |  |  |  |  |  | $ 45,000,000.0 |
Milestone Payment Received |  |  |  |  |  |  |  |  | $ 12,500,000 |  |
Total transaction price | 105,800,000 |  |  |  |  | 105,800,000 |  |  |  |  |
Increase in total consideration | 2,700,000 |  |  |  |  |  |  |  |  |  |
Deferred revenue | 33,100,000 |  |  |  |  | 33,100,000 |  |  |  |  |
Collaboration and License Agreement | United Therapeutics Corporation | Clinical Supplies |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Deferred revenue - current | 1,200,000 |  |  |  |  | 1,200,000 |  |  |  |  |
Collaboration and License Agreement | United Therapeutics Corporation | Maximum |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Additional option exercise and development milestone payments to be receive | 40,000,000.0 |  |  |  |  | 40,000,000.0 |  |  |  |  |
Collaboration and License Agreement | United Therapeutics Corporation | Collaborations and services |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue' collaborations and services |  |  |  | $ 400,000 |  |  |  |  |  |  |
Research Agreement | United Therapeutics Corporation |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Upfront payment received |  |  |  |  |  |  |  |  |  |  | $ 10,000,000.0
Total transaction price | 10,000,000.0 |  |  |  |  | 10,000,000.0 |  |  |  |  |
Research Agreement | United Therapeutics Corporation | Maximum |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Potential milestone payments to be receive | 30,000,000.0 |  |  |  |  | 30,000,000.0 |  |  |  |  |
Research Agreement | United Therapeutics Corporation | Collaborations and services |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue' collaborations and services |  |  |  |  |  | 210,000 | 6,032,000 |  |  |  |
Research Agreement | United Therapeutics Corporation | Engineering Consulting Services |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total transaction price | 1,000,000.0 |  |  |  |  | $ 1,000,000.0 |  |  |  |  |
Revenue performance obligation, method used |  |  |  |  |  | The revenue for the engineering consulting services was recognized using a ratable method until the obligation was satisfied. The Company believed that this method best reflected the measure of progress toward complete satisfaction of the performance obligation. |  |  |  |  |
Research Agreement | United Therapeutics Corporation | Product Prototype |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total transaction price | 9,000,000.0 |  |  |  |  | $ 9,000,000.0 |  |  |  |  |
Revenue performance obligation, method used |  |  |  |  |  | The revenue for the product prototype was recognized using an output method (based on project milestones achieved and surveys of performance completed to date). The Company believed that this method best reflected the measure of progress toward complete satisfaction of the performance obligation. |  |  |  |  |
Supply and Distribution Agreement | Commercial product sales | Biomm |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue' collaborations and services |  | $ 700,000 |  |  | $ 200,000 | $ 0 |  |  |  |  |
License and Distribution Agreement | Foreign Country | India Tax Authority |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Income Taxes Paid |  |  |  |  |  |  |  | $ 200,000 |  |  |
License and Distribution Agreement | Cipla Ltd |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Deferred revenue | 1,800,000 |  |  |  |  | 1,800,000 |  |  |  |  |
Deferred revenue - current | 100,000 |  |  |  |  | 100,000 |  |  |  |  |
Marketing and distribution agreement date |  |  | 2018-05 |  |  |  |  |  |  |  |
Deferred revenue - long term | $ 1,700,000 |  |  |  |  | 1,700,000 |  |  |  |  |
License and Distribution Agreement | Collaborations and services | Cipla Ltd |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue' collaborations and services |  |  |  |  |  | $ 147,000 | $ 148,000 |  |  |  |

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