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Collaboration, Licensing and Other Arrangements - Additional Information (Detail 1) - USD ($) $ in Millions	Dec. 31, 2020	May 31, 2018	Dec. 31, 2016
Collaboration and License Agreement | Receptor CLA | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date: 2017-01-01
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Deferred revenue recognition period			4 years
Deferred revenue - nonrefundable license fee			$ 1.0
Collaboration and License Agreement | United Therapeutics Corporation
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Deferred revenue - nonrefundable license fee	$ 105.8
Collaboration and License Agreement | United Therapeutics Corporation | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date: 2018-10-01
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Deferred revenue recognition period	39 months
License and Distribution Agreement | Cipla Ltd | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date: 2018-06-01
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Deferred revenue recognition period		15 years
Deferred revenue - nonrefundable license fee		$ 2.2

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
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