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Common and Preferred Stock - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 3 Months Ended 12 Months Ended
Feb. 25, 2021
Jan. 01, 2021
Dec. 07, 2020
Oct. 09, 2020
Jun. 24, 2020
Dec. 26, 2019
Dec. 23, 2019
Feb. 28, 2021
Jan. 31, 2021
Dec. 31, 2020
Jul. 31, 2019
Dec. 31, 2018
Feb. 28, 2018
Dec. 31, 2020
Dec. 31, 2020
Dec. 31, 2019
Class of Stock [Line Items]                                
Common stock, shares authorized                   400,000,000       400,000,000 400,000,000 280,000,000
Common stock, par value                   $ 0.01       $ 0.01 $ 0.01 $ 0.01
Undesignated preferred stock, shares authorized                   10,000,000       10,000,000 10,000,000 10,000,000
Undesignated preferred stock, par value                   $ 0.01       $ 0.01 $ 0.01 $ 0.01
Common stock, shares issued                   242,117,089       242,117,089 242,117,089 211,787,573
Common stock, shares outstanding                   242,117,089       242,117,089 242,117,089 211,787,573
Undesignated preferred stock, shares outstanding                   0       0 0 0
Other expense                             $ (9,545) $ (7,306)
QrumPharma                                
Class of Stock [Line Items]                                
Number of common stock issued     3,067,179             3,067,179            
MidCap Credit Facility                                
Class of Stock [Line Items]                                
Warrants to purchase of common stock                   111,853       111,853 111,853  
Warrants expiration date                   Dec. 01, 2027       Dec. 01, 2027 Dec. 01, 2027  
Convertible Promissory Note | The Mann Group                                
Class of Stock [Line Items]                                
Issuance of common stock to note holders                           2,800,000    
Conversion of notes accrued interest to common shares, value                           $ 3,000    
Conversion of notes accrued interest to common shares                           1,200,000    
Conversion of notes to common shares, value                           $ 7,000    
Convertible Promissory Note | Subsequent Event | The Mann Group                                
Class of Stock [Line Items]                                
Issuance of common stock to note holders 4,000,000.0               4,000,000.0              
Conversion of notes accrued interest to common shares, value                 $ 400              
Conversion of notes to common shares, value $ 9,600               $ 9,600              
2024 Convertible Notes | Scenario Forecast                                
Class of Stock [Line Items]                                
Issuance of common stock to note holders               1,700,000                
Conversion of notes to common shares, value               $ 5,000                
2024 Convertible Notes | Subsequent Event                                
Class of Stock [Line Items]                                
Issuance of common stock to note holders   1,666,667                            
Conversion of notes to common shares, value   $ 5,000                            
Common Stock | June 2020 Note                                
Class of Stock [Line Items]                                
Issuance of common stock to note holders         1,235,094                      
Common Stock | December 2020 Note                                
Class of Stock [Line Items]                                
Issuance of common stock to note holders       1,377,356                        
Contolled Equity Offering Sales Agreement | Cantor Fitzgerald                                
Class of Stock [Line Items]                                
Stock purchase agreements date                         Feb. 28, 2018      
Contolled Equity Offering Sales Agreement | Cantor Fitzgerald | Common Stock | Maximum                                
Class of Stock [Line Items]                                
Amount of net proceeds from issuance of securities                         $ 50,000      
At Market Issuance Sales Agreement | Cantor Fitzgerald | Common Stock                                
Class of Stock [Line Items]                                
Amount of net proceeds from issuance of securities                             $ 23,500 $ 3,200
Number of shares sold during the period                             11,851,566 2,584,964
Exchange price per share                   $ 1.99       $ 1.99 $ 1.99 $ 1.24
Underwriting Agreement with Leerink Partners LLC                                
Class of Stock [Line Items]                                
Stock purchase agreements date                       Dec. 31, 2018        
Exercise price of warrants             $ 1.311                  
Warrants expiration, date             Jun. 26, 2020         Dec. 26, 2019        
Warrants modified             11,750,000                  
Warrants exercised             4,500,000                  
Warrants expired unexercised           11,583,333                    
Remaining warrants available for purchase           7,250,000                 7,250,000  
Underwriting Agreement with Leerink Partners LLC | Minimum                                
Class of Stock [Line Items]                                
Warrants exercised             4,500,000                  
Underwriting Agreement with Leerink Partners LLC | Common Stock                                
Class of Stock [Line Items]                                
Amount of net proceeds from issuance of securities                       $ 37,300        
Exchange price per share                       $ 1.50        
Underwriting Agreement with Leerink Partners LLC | Common Stock | Initial Public Offering                                
Class of Stock [Line Items]                                
Number of shares sold during the period                       26,666,667        
Underwriting Agreement with Leerink Partners LLC | Warrant                                
Class of Stock [Line Items]                                
Amount of net proceeds from issuance of securities             $ 5,900                  
Exercise price of warrants           $ 1.60       $ 1.60   $ 1.60   $ 1.60 $ 1.60  
Repurchase of common stock , shares                     3,333,334          
Repurchase of common stock , value                     $ 400          
Additional paid-in capital             $ 700       200          
Other expense                     $ 200          
Remained available warrants expiration period                       2020-06        
Underwriting Agreement with Leerink Partners LLC | Warrant | Maximum                                
Class of Stock [Line Items]                                
Warrants to purchase of common stock                       26,666,667