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Commitments and Contingencies - Additional Information (Detail)
 1 Months Ended 3 Months Ended 12 Months Ended
Dec. 26, 2019
$ / shares
shares
Dec. 23, 2019
$ / shares
Aug. 31, 2019
Dec. 31, 2018
$ / shares
shares
Nov. 30, 2017
USD ($)
May 31, 2017
USD ($)
Jun. 30, 2018
USD ($)
Vehicle
Dec. 31, 2020
USD ($)
$ / shares
shares
Dec. 31, 2019
USD ($)
Vehicle
Nov. 30, 2020
$ / shares
shares
Aug. 06, 2019
$ / shares
shares
Jan. 01, 2019
USD ($)
Jul. 01, 2013
USD ($)
Commitments And Contingencies [Line Items]                          
Purchase obligation extended term     2026                    
Supply Agreement expiration period               Dec. 31, 2026          
Supply Agreement renewal period               2 years          
Foreign currency hedging transactions period               90 days          
Operating lease, non-current liabilities               $ 1,202,000 $ 2,514,000        
Operating lease costs               1,400,000 1,500,000        
Operating lease, cash paid               1,800,000 1,800,000        
Variable lease costs               $ 400,000 $ 400,000        
Operating lease, weighted average discount rate               7.50% 7.50%        
Operating lease, weighted-average remaining lease term               1 year 10 months 24 days 3 years        
Underwriting Agreement with Leerink Partners LLC                          
Commitments And Contingencies [Line Items]                          
Exercise price of warrants | $ / shares   $ 1.311                      
Stock purchase agreements date       Dec. 31, 2018                  
Warrants expiration, date   Jun. 26, 2020   Dec. 26, 2019                  
Warrants expired unexercised | shares 11,583,333                        
Remaining warrants available for purchase | shares 7,250,000             7,250,000          
Underwriting Agreement with Leerink Partners LLC | Common Stock                          
Commitments And Contingencies [Line Items]                          
Exchange price per share | $ / shares       $ 1.50                  
Underwriting Agreement with Leerink Partners LLC | Warrant                          
Commitments And Contingencies [Line Items]                          
Exercise price of warrants | $ / shares $ 1.60     $ 1.60       $ 1.60          
Underwriting Agreement with Leerink Partners LLC | Initial Public Offering | Common Stock                          
Commitments And Contingencies [Line Items]                          
Number of shares sold during the period | shares       26,666,667                  
Lease Agreement with Enterprise | Vehicle Leases                          
Commitments And Contingencies [Line Items]                          
Number of vehicle leases | Vehicle             119   90        
Operating lease rent expenses             $ 83,000   $ 70,000        
Number of vehicle leases removed | Vehicle                 29        
Gain or loss recorded for leases removed                 $ 0        
Lease expiration period             48 months            
Operating lease right-of-use assets                       $ 1,600,000  
Operating lease liabilities                       1,900,000  
Operating lease, non-current other assets                       1,600,000  
Operating lease, other current liabilities                       600,000  
Operating lease, non-current liabilities                       1,300,000  
Cost of Goods Sold                          
Commitments And Contingencies [Line Items]                          
Payment of long term purchase commitment, amendment fees               $ 0 $ 2,800,000        
Maximum | Underwriting Agreement with Leerink Partners LLC | Warrant                          
Commitments And Contingencies [Line Items]                          
Warrants to purchase of common stock | shares       26,666,667                  
MidCap Credit Facility                          
Commitments And Contingencies [Line Items]                          
Exercise price of warrants | $ / shares                   $ 2.91 $ 1.11    
Warrants to purchase of common stock | shares                   111,853 1,171,614    
Deerfield | Milestone Rights Liability                          
Commitments And Contingencies [Line Items]                          
Contingent liability remain payable               70,000,000.0          
Accrued expenses and other current liabilities               1,300,000          
Milestone rights and other liabilities               $ 5,900,000          
Deerfield | Milestone Rights Liability | Maximum                          
Commitments And Contingencies [Line Items]                          
Contingent liability for milestone payments                         $ 90,000,000.0
Russell Ranch Road II LLC | Office Lease                          
Commitments And Contingencies [Line Items]                          
Operating lease rent expenses         $ 35,969 $ 40,951              
Operating lease right-of-use assets                       3,200,000  
Operating lease liabilities                       3,500,000  
Operating lease, other current liabilities                       900,000  
Operating lease, non-current liabilities                       $ 2,600,000  
Percentage of annual increase in lease payment         3.00% 3.00%              
Lease expiration date         Jan. 31, 2023 Jan. 31, 2023              
Lease renewal option         5 years 5 years              
Reimbursement amount received for tenant improvements         $ 56,325