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Condensed Consolidated Statements of Stockholders' Deficit - USD ($) $ in Thousands | Total | Convertible Note Mann Group | Convertible Note Interest Mann Group | 2024 Convertible Notes | 2024 Convertible Note Interest | At The Market Offering | Common Stock | Common Stock Convertible Note Mann Group | Common Stock Convertible Note Interest Mann Group | Common Stock 2024 Convertible Notes | Common Stock 2024 Convertible Note Interest | Common Stock At The Market Offering | Additional Paid-in Capital | Additional Paid-in Capital Convertible Note Mann Group | Additional Paid-in Capital Convertible Note Interest Mann Group | Additional Paid-in Capital 2024 Convertible Notes | Additional Paid-in Capital 2024 Convertible Note Interest | Additional Paid-in Capital At The Market Offering | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning Balance at Dec. 31, 2019 | $ (190,526) |  |  |  |  |  | $ 2,118 |  |  |  |  |  | $ 2,799,278 |  |  |  |  |  | $ (19) | $ (2,991,903)
Beginning Balance (in shares) at Dec. 31, 2019 |  |  |  |  |  |  | 211,788,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 318 |  |  |  |  |  | $ 3 |  |  |  |  |  | 315 |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  |  |  |  | 333,727 |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 1,128 |  |  |  |  |  |  |  |  |  |  |  | 1,128 |  |  |  |  |  |  |
Issuance of common stock associated with debt interest payment | 144 |  |  |  |  |  | $ 1 |  |  |  |  |  | 143 |  |  |  |  |  |  |
Issuance of common stock associated with debt interest payment (in shares) |  |  |  |  |  |  | 99,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units | (317) |  |  |  |  |  | $ 5 |  |  |  |  |  | (322) |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units (in shares) |  |  |  |  |  |  | 504,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock |  |  |  |  |  | $ 522 |  |  |  |  |  | $ 4 |  |  |  |  |  | $ 518 |  |
Issuance of common stock (in shares) |  |  |  |  |  |  |  |  |  |  |  | 413,000 |  |  |  |  |  |  |  |
Issuance cost associated with at-the-market offering | (16) |  |  |  |  |  |  |  |  |  |  |  | (16) |  |  |  |  |  |  |
Write-off of cumulative translation loss | 19 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 19 |
Net loss | (9,322) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (9,322)
Ending Balance at Mar. 31, 2020 | (198,050) |  |  |  |  |  | $ 2,131 |  |  |  |  |  | 2,801,044 |  |  |  |  |  |  | (3,001,225)
Ending Balance (in shares) at Mar. 31, 2020 |  |  |  |  |  |  | 213,138,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning Balance at Dec. 31, 2020 | (180,419) |  |  |  |  |  | $ 2,421 |  |  |  |  |  | 2,866,303 |  |  |  |  |  |  | (3,049,143)
Beginning Balance (in shares) at Dec. 31, 2020 |  |  |  |  |  |  | 242,118,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 390 |  |  |  |  |  | $ 3 |  |  |  |  |  | 387 |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  |  |  |  | 292,981 |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 1,935 |  |  |  |  |  |  |  |  |  |  |  | 1,935 |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units | 397 |  |  |  |  |  | $ 4 |  |  |  |  |  | 393 |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units (in shares) |  |  |  |  |  |  | 390,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock pursuant to conversion notes |  | $ 9,573 | $ 427 | $ 5,000 |  |  |  | $ 38 | $ 2 | $ 17 |  |  |  | $ 9,535 | $ 425 | $ 4,983 |  |  |  |
Issuance of common stock pursuant to conversion notes (in shares) |  |  |  |  |  |  |  | 3,830,000 | 170,000 | 1,667,000 |  |  |  |  |  |  |  |  |  |
Issuance of common stock pursuant to payoff of the 2024 convertible note interest |  |  |  |  | $ 143 |  |  |  |  |  |  |  |  |  |  |  | $ 143 |  |  |
Issuance of common stock pursuant to payoff of the 2024 convertible note interest (in shares) |  |  |  |  |  |  |  |  |  |  | 27,000 |  |  |  |  |  |  |  |  |
Issuance of common stock |  |  |  |  |  | $ 1,886 |  |  |  |  |  | $ 6 |  |  |  |  |  | $ 1,880 |  |
Issuance of common stock (in shares) |  |  |  |  |  |  |  |  |  |  |  | 578,000 |  |  |  |  |  |  |  |
Issuance cost associated with at-the-market offering | (38) |  |  |  |  |  |  |  |  |  |  |  | (38) |  |  |  |  |  |  |
Net loss | (12,916) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (12,916)
Ending Balance at Mar. 31, 2021 | $ (173,622) |  |  |  |  |  | $ 2,491 |  |  |  |  |  | $ 2,885,946 |  |  |  |  |  |  | $ (3,062,059)
Ending Balance (in shares) at Mar. 31, 2021 |  |  |  |  |  |  | 249,073,000 |  |  |  |  |  |  |  |  |  |  |  |  |

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