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Collaboration, Licensing and Other Arrangements - Additional Information (Detail) - USD ($) | 1 Months Ended | 3 Months Ended | 12 Months Ended | 20 Months Ended |
--- | --- | --- | --- | --- | ---
Dec. 31, 2020 | Sep. 30, 2019 | May 31, 2018 | Mar. 31, 2021 | Jun. 30, 2020 | Mar. 31, 2020 | Dec. 31, 2020 | Nov. 30, 2020 | Oct. 31, 2018
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Revenue' collaborations and services |  |  |  | $ 17,436,000 |  | $ 16,235,000 |  |  |
Deferred revenue - current | $ 33,275,000 |  |  | 25,880,000 |  |  | $ 33,275,000 |  |
Deferred revenue - long term | 1,662,000 |  |  | 1,626,000 |  |  | 1,662,000 |  |
Commercial product sales |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Revenue' collaborations and services |  |  |  | 8,099,000 |  | $ 8,000,000 |  |  |
Collaboration and License Agreement | United Therapeutics Corporation |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upfront payment received |  |  |  |  |  |  |  |  | $ 45,000,000.0
Milestone Payment Received |  |  |  |  |  |  |  | $ 12,500,000 |
Deferred revenue |  |  |  | 25,600,000 |  |  |  |  |
Increase in total consideration | $ 2,700,000 |  |  |  |  |  |  |  |
Collaboration and License Agreement | United Therapeutics Corporation | Clinical Supplies |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Total transaction price |  |  |  | 105,800,000 |  |  |  |  |
Collaboration and License Agreement | United Therapeutics Corporation | Maximum |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Additional option exercise and development milestone payments to be receive |  |  |  | 40,000,000.0 |  |  |  |  |
Co-Promotion Agreement | Vertice Pharma LLC |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Total transaction price |  |  |  | 6,300,000 |  |  |  |  |
Supply and Distribution Agreement | Biomm | Commercial product sales |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Revenue' collaborations and services |  | $ 700,000 |  | 0 | $ 200,000 |  | $ 0 |  |
License and Distribution Agreement | Cipla Ltd |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Deferred revenue |  |  |  | 1,800,000 |  |  |  |  |
Marketing and distribution agreement date |  |  | 2018-05 |  |  |  |  |  |
Deferred revenue - current |  |  |  | 200,000 |  |  |  |  |
Deferred revenue - long term |  |  |  | $ 1,600,000 |  |  |  |  |

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