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Collaboration, Licensing and Other Arrangements - Additional Information (Detail) - USD ($)	1 Months Ended			3 Months Ended			12 Months Ended	20 Months Ended
	Dec. 31, 2020	Sep. 30, 2019	May 31, 2018	Mar. 31, 2021	Jun. 30, 2020	Mar. 31, 2020	Dec. 31, 2020	Nov. 30, 2020	Oct. 31, 2018
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenue' collaborations and services				$ 17,436,000		$ 16,235,000
Deferred revenue - current	$ 33,275,000			25,880,000			$ 33,275,000
Deferred revenue - long term	1,662,000			1,626,000			1,662,000
Commercial product sales
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenue' collaborations and services				8,099,000		$ 8,000,000
Collaboration and License Agreement | United Therapeutics Corporation
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront payment received									$ 45,000,000.0
Milestone Payment Received								$ 12,500,000
Deferred revenue				25,600,000
Increase in total consideration	$ 2,700,000
Collaboration and License Agreement | United Therapeutics Corporation | Clinical Supplies
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Total transaction price				105,800,000
Collaboration and License Agreement | United Therapeutics Corporation | Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Additional option exercise and development milestone payments to be receive				40,000,000.0
Co-Promotion Agreement | Vertice Pharma LLC
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Total transaction price				6,300,000
Supply and Distribution Agreement | Biomm | Commercial product sales
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenue' collaborations and services		$ 700,000		0	$ 200,000		$ 0
License and Distribution Agreement | Cipla Ltd
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Deferred revenue				1,800,000
Marketing and distribution agreement date			2018-05
Deferred revenue - current				200,000
Deferred revenue - long term				$ 1,600,000

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