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Description of Business and Significant Accounting Policies - Additional Information (Detail) |  |  | 1 Months Ended | 3 Months Ended | 9 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Apr. 22, 2021 USD ($) | Apr. 10, 2020 USD ($) | Jun. 30, 2021 USD ($) | Mar. 31, 2021 USD ($) | Apr. 30, 2020 USD ($) | Sep. 30, 2021 USD ($) | Sep. 30, 2020 USD ($) | Sep. 30, 2021 USD ($) Segment Contract | Sep. 30, 2020 USD ($) | Dec. 31, 2020 USD ($) | Aug. 31, 2019 USD ($) | Jul. 01, 2013 USD ($)
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Accumulated deficit |  |  |  |  |  |  | $ (3,102,008,000) |  | $ (3,102,008,000) |  | $ (3,049,143,000) |  |
Principal amount |  |  |  |  |  |  | 288,400,000 |  | 288,400,000 |  |  |  |
Cash and cash equivalents |  |  |  |  |  |  | 51,740,000 | $ 52,398,000 | 51,740,000 | $ 52,398,000 | 67,005,000 |  |
Short-term investments |  |  |  |  |  |  | 87,312,000 |  | 87,312,000 |  |  |  |
Long-term investments |  |  |  |  |  |  | 42,059,000 |  | $ 42,059,000 |  |  |  |
Debt issuance amount |  |  |  |  | $ 230,000,000.0 |  |  |  |  |  |  |  |
Debt issuance percentage |  |  |  |  | 2.50% |  |  |  |  |  |  |  |
Number of operating segment | Segment |  |  |  |  |  |  |  |  | 1 |  |  |  |
Proceeds from loans |  |  |  |  |  |  |  |  |  | 4,873,000 |  |  |
Accretion or amortization |  |  |  |  |  |  | 200,000 | $ 0 | $ 300,000 | 0 |  |  |
Allowance for credit losses on held-to-maturity securities |  |  |  |  |  |  | $ 0 |  | 0 |  |  |  |
Proceeds from investment securities |  |  |  |  |  |  |  |  | $ 105,724,000 |  |  |  |
ASU 2020-06 |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Change in accounting principle accounting standards update adopted |  |  |  |  |  |  | true |  | true |  |  |  |
Change in accounting principle accounting standards update adoption date |  |  |  |  |  |  | Jan. 01, 2021 |  | Jan. 01, 2021 |  |  |  |
Change in accounting principle accounting standards update immaterial effect |  |  |  |  |  |  | true |  | true |  |  |  |
Change in accounting principle accounting standards update early adoption |  |  |  |  |  |  | true |  | true |  |  |  |
Commitment Asset | Other Expense |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Asset impairment |  |  |  |  |  |  |  |  |  | $ 1,900,000 |  |  |
Paycheck Protection Program Loan, CARES Act |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount | [1] |  |  |  |  |  |  |  |  |  | 4,900,000 |  |
Proceeds from loans |  |  | $ 4,900,000 |  |  | $ 4,900,000 |  |  |  |  |  |  |
Convertible Promissory Note | Thirona Bio, Inc. |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Investment securities |  |  |  | $ 3,000.0 |  |  | $ 3,000.0 |  | $ 3,000.0 |  |  |  |
Proceeds from investment securities |  |  |  | $ 3,000.0 |  |  |  |  |  |  |  |  |
Maturity date |  |  |  | 2022-12 |  |  |  |  |  |  |  |  |
Interest rate |  |  |  | 6.00% |  |  |  |  |  |  |  |  |
Insulin |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Loss on purchase commitments |  |  |  |  |  |  | 85,300,000 |  | $ 85,300,000 |  | 95,300,000 |  |
Loss on purchase commitments, number of new contracts recognized | Contract |  |  |  |  |  |  |  |  | 0 |  |  |  |
Maximum | AFREZZA product sales |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Sales return right following product expiration in months |  |  |  |  |  |  |  |  | 12 months |  |  |  |
Minimum | AFREZZA product sales |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Sales return right following product expiration in months |  |  |  |  |  |  |  |  | 6 months |  |  |  |
MidCap Credit Facility |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Principal amount | [2] |  |  |  |  |  | 40,000,000.0 |  | $ 40,000,000.0 |  | $ 50,000,000.0 |  |
Principal amount |  |  |  |  |  |  |  |  |  |  |  | $ 100,000,000.0 |
Amount outstanding |  |  |  |  |  |  | 40,000,000.0 |  | 40,000,000.0 |  |  |  |
Principal prepayment against outstanding term loans |  | $ 10,000,000.0 |  |  |  |  |  |  |  |  |  |  |
Commitment asset |  |  |  |  |  |  |  |  |  |  |  | 1,500,000 |
Other asset |  |  |  |  |  |  |  |  |  |  |  | $ 400,000 |
Milestone Rights Liability | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent liability remain payable |  |  |  |  |  |  | $ 65,000,000.0 |  | $ 65,000,000.0 |  |  |  |
Milestone Rights Liability | Maximum | Deerfield |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent liability for milestone payments |  |  |  |  |  |  |  |  |  |  |  |  | $ 90,000,000.0
[1] | In July 2021, the Company received full forgiveness from the SBA for the $4.9 million principal balance of the PPP loan and recognized a gain on extinguishment of debt for the full principal balance and a de minimis amount of accrued but unpaid interest
[2] | In April 2021, the Company prepaid $10.0 million principal balance and amended the MidCap credit facility. The interest rate prior to the amendment was one-month LIBOR (2% floor) plus 6.75% and the maturity date was in August 2024

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