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Schedule of Revenue from Collaborations and Services (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenue from collaborations and services | $ 75,442 | $ 65,144
Collaborations and services |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenue from collaborations and services | 36,274 | 32,820
Collaborations and services | License Agreement | United Therapeutics Corporation |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenue from collaborations and services | 34,145 | 32,213
Collaborations and services | Commercial Supply Agreement | United Therapeutics Corporation |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenue from collaborations and services | 267 |
Collaborations and services | Co-Promotion Agreement | Vertice Pharma LLC |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenue from collaborations and services | 1,147 |
Collaborations and services | Collaboration and License Agreement | Receptor CLA |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenue from collaborations and services | 245 | 250
Collaborations and services | License and Distribution Agreement | Cipla Ltd |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenue from collaborations and services | 147 | 147
Collaborations and services | Other |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenue from collaborations and services | $ 323 |
Collaborations and services | Research Agreement | United Therapeutics Corporation |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Total revenue from collaborations and services |  | $ 210

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