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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
CASH FLOWS FROM OPERATING ACTIVITIES: |  |
Net loss | $ (80,926) | $ (57,240)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Loss on extinguishment of debt, net | 17,200 | 264
Stock-based compensation expense | 12,200 | 6,511
Depreciation, amortization and accretion | 4,215 | 2,149
Interest on milestone right | 3,663 |
Write-off of inventory | 1,902 | 496
Interest expense on promissory notes | 1,598 | 5,148
Amortization of financing liability | 1,372 |
Amortization of right-of-use assets | 1,258 | 1,177
Asset impairment | 106 | 1,889
(Gain) loss on foreign currency translation | (6,567) | 8,006
In-process research and development |  | 13,233
Other, net |  | 19
Changes in operating assets and liabilities: |  |
Accounts receivable, net | (776) | (705)
Inventory | (4,081) | (1,314)
Prepaid expenses and other current assets | (360) | (154)
Other assets | (138) | 227
Accounts payable | 1,374 | 793
Accrued expenses and other current liabilities | 8,814 | 3,346
Deferred revenue | (14,567) | (5,910)
Recognized loss on purchase commitments | (5,892) | (4,751)
Operating lease liabilities | (2,135) | (1,312)
Accrued interest on Mann Group promissory notes | (4,919) |
Deposits from customer | 4,950 |
Net cash used in operating activities | (61,709) | (28,128)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |
Purchase of held-to-maturity debt securities | (196,131) |
Proceeds from maturity of debt securities | 59,060 |
Purchase of property and equipment | (11,466) | (801)
Purchase of available-for-sale securities | (3,000) |
Proceeds from sale of treasury bills |  | 20,000
Acquisition of in-process research and development, net of cash acquired |  | (3,983)
Net cash (used in) provided by investing activities | (151,537) | 15,216
CASH FLOWS FROM FINANCING ACTIVITIES: |  |
Proceeds from the Senior convertible notes | 230,000 |
Issuance costs associated with Senior convertible notes | (7,268) |
Proceeds from the sale-leaseback transaction | 102,250 |
Issuance costs associated with the sale-leaseback transaction | (3,120) |
Deposit for the sale-leaseback transaction | (2,000) |
Principal payments on Mann Group promissory notes | (35,051) |
Payment of MidCap credit facility | (10,000) |
Payment of MidCap credit facility prepayment penalty | (1,000) |
Milestone payment | (5,000) |
Payment of employment taxes related to vested restricted stock units and exercise of stock options | (498) | 233
Proceeds from market price stock purchase plan | 106 | 215
Issuance of common stock from the exercise of warrants |  | 11,600
Proceeds from MidCap credit facility |  | 10,000
Proceeds from PPP loan |  | 4,873
Net cash provided by financing activities | 270,267 | 49,853
NET INCREASE IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH | 57,021 | 36,941
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD | 67,163 | 30,222
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD | 124,184 | 67,163
At The Market Issuance |  |
CASH FLOWS FROM FINANCING ACTIVITIES: |  |
Issuance costs associated with the sale-leaseback transaction | (38) | (518)
Proceeds from public offering | $ 1,886 | $ 23,450

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