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Description of Business - Additional Information (Detail) - USD ($) $ in Thousands | 1 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | ---
Mar. 31, 2021 | Dec. 31, 2021 | Dec. 31, 2020 | Nov. 30, 2020 | Dec. 31, 2019 | Aug. 31, 2019
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Accumulated deficit |  |  | $ (3,130,069) | $ (3,049,143) |  |  |
Principal amount |  |  | 288,400 |  |  |  |
Cash and cash equivalents |  |  | 124,184 | 67,005 |  |  |
Short-term investments |  |  | 79,932 |  |  |  |
Long-term investments |  |  | 56,619 |  |  |  |
Debt issuance amount |  | $ 230,000 |  |  |  |  |
Debt issuance percentage |  | 2.50% |  |  |  |  |
MidCap Credit Facility |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Principal amount | [1] |  | $ 40,000 | $ 50,000 |  |  |
Principal amount |  |  |  |  |  |  | $ 100,000
Amount outstanding |  |  |  |  |  | $ 40,000 |
Minimum cash covenant |  |  |  |  | $ 30,000 |  | $ 90,000
[1] | In April 2021, the Company prepaid $10.0 million principal balance and amended the MidCap credit facility. The interest rate prior to the amendment was one-month LIBOR (2% floor) plus 6.75% and the maturity date was in August 2024.

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