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Components of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 542,800 | $ 533,448
Research and development credits | 78,804 | 79,455
Milestone Rights | 1,440 | 1,547
Accrued expenses | 2,591 | 1,436
Loss on purchase commitment | 24,845 | 23,864
Non-qualified stock option expense | 5,684 | 3,766
Capitalized patent costs | 7,518 | 5,273
Other | 2,568 | 2,093
Lease liability | 588 | 559
Interest expense limitation | 5,696 | 2,460
Depreciation | 22,983 | 20,735
Deferred Product Revenue & Costs | 404 | 1,569
Total net deferred tax assets | 695,921 | 676,205
Valuation allowance | (695,094) | (675,463)
Net deferred tax assets | 827 | 742
Deferred tax liabilities: |  |
Right of use asset | (555) | (510)
Other prepaids | (272) | (232)
Total deferred tax liabilities | $ (827) | $ (742)

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