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Income Taxes - Additional Information (Detail) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Aug. 31, 2004 | Dec. 31, 2021 | Dec. 31, 2020
Income Taxes [Line Items] |  |  |
Valuation allowance of deferred tax asset |  | $ 695,094,000 | $ 675,463,000
Change in the valuation allowance |  | 19,631,000 | 4,846,000
Federal operating loss carryforwards |  | 2,200,000,000 |
State operating loss carryforwards |  | 1,300,000,000 |
Federal operation loss carryforwards, not subject to expiration |  | $ 452,700,000 |
Operating loss carryforwards, limitations on use |  | Pursuant to IRC Sections 382 and 383, annual use of the Company’s federal and California net operating loss and research and development credit carryforwards may be limited in the event a cumulative change in ownership of more than 50% occurs within a three-year period. |
Net operating loss carryforwards | $ 216,000,000.0 |  |
Net operating loss and credit carryforwards, annual use limitation | $ 13,000,000.0 |  |
Research and development credits begin to expire |  | 2021 |
Research and development credits |  | $ 78,804,000 | 79,455,000
Research and development credits expire |  | 1,200,000 |
Unrecognized income tax interest and penalties |  | 0 | 0
Federal |  |  |
Income Taxes [Line Items] |  |  |
Research and development credits not expire |  | $ 54,200,000 |
Research and development credits begin to expire |  | 2024 |
State |  |  |
Income Taxes [Line Items] |  |  |
Research and development credits not expire |  | $ 24,600,000 |
New Jersey |  |  |
Income Taxes [Line Items] |  |  |
Research and development credits begin to expire |  | 2021 |
Connecticut |  |  |
Income Taxes [Line Items] |  |  |
Research and development credits not expire |  |  | 19,800,000
Research and development credits |  |  | $ 100,000
California |  |  |
Income Taxes [Line Items] |  |  |
Research and development credits not expire |  | $ 2,000,000.0 |
Research and development credits |  | $ 2,200,000 |

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