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Schedule of Revenue from Collaborations and Services (Detail) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 31, 2022 | Mar. 31, 2021
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Total revenue from collaborations and services |  | $ 11,992 | $ 17,436
Collaborations and services |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Total revenue from collaborations and services |  | 2,166 | 9,337
Collaborations and services | License Agreement | United Therapeutics Corporation |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Total revenue from collaborations and services | [1] | 1,348 | 8,999
Collaborations and services | Commercial Supply Agreement | United Therapeutics Corporation |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Total revenue from collaborations and services | [2] | 694 |
Collaborations and services | License and Distribution Agreement | Cipla Ltd |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Total revenue from collaborations and services |  | 37 | 36
Collaborations and services | Other |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Total revenue from collaborations and services |  | $ 87 |
Collaborations and services | Co-Promotion Agreement | Vertice Pharma LLC |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Total revenue from collaborations and services |  |  | 292
Collaborations and services | Collaboration and License Agreement | Receptor CLA |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Total revenue from collaborations and services |  |  | $ 10
[1] | Amounts consist of revenue recognized for Next-Gen R&D Services for the three months ended March 31, 2022 and R&D Services and License for the three months ended March 31, 2021
[2] | Amount consists of revenue recognized for Manufacturing Services for the three months ended March 31, 2022

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