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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2022-05-04T23:08:55.4168665+00:00 -->
<!-- Version            : 5.0.1.747 -->
<!-- Package ID         : de369a4b3a9d4c30b801f9caa946a98d -->
<!-- Copyright (c) 2022 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="mnkd_FinanceLeaseLiabilityDiscountedPaymentsDueRemainderOfFiscalYear" name="FinanceLeaseLiabilityDiscountedPaymentsDueRemainderOfFiscalYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_FinanceLeaseLiabilityDiscountedPaymentsDueNextTwelveMonths" name="FinanceLeaseLiabilityDiscountedPaymentsDueNextTwelveMonths" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_FinanceLeaseLiabilityDiscountedPaymentsDueYearTwo" name="FinanceLeaseLiabilityDiscountedPaymentsDueYearTwo" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_FinanceLeaseLiabilityDiscountedPaymentsDueYearThree" name="FinanceLeaseLiabilityDiscountedPaymentsDueYearThree" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_FinanceLeaseLiabilityDiscountedPaymentsDueYearFour" name="FinanceLeaseLiabilityDiscountedPaymentsDueYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_FinanceLeaseLiabilityDiscountedPaymentsDueAfterYearFour" name="FinanceLeaseLiabilityDiscountedPaymentsDueAfterYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_FinanceLeaseLiabilityDiscountedExcessAmount" name="FinanceLeaseLiabilityDiscountedExcessAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_FinanceLeaseLiabilityDiscountedDebtIssuanceCosts" name="FinanceLeaseLiabilityDiscountedDebtIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_FinanceLeaseLiabilityDiscounted" name="FinanceLeaseLiabilityDiscounted" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PurchaseObligationCurrent" name="PurchaseObligationCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_CreditFacilityNoncurrent" name="CreditFacilityNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PromissoryNotesNoncurrent" name="PromissoryNotesNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AccruedInterestNoncurrent" name="AccruedInterestNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PurchaseObligationNoncurrent" name="PurchaseObligationNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_MilestoneRightsLiabilitiesNoncurrent" name="MilestoneRightsLiabilitiesNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_InterestExpenseOnFinancingLiability" name="InterestExpenseOnFinancingLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_StockIssuedDuringPeriodSharesStockOptionsAndRestrictedStockUnitsNetOfForfeitures" name="StockIssuedDuringPeriodSharesStockOptionsAndRestrictedStockUnitsNetOfForfeitures" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_StockIssuedDuringPeriodValueStockOptionsAndRestrictedStockUnitsNetOfForfeitures" name="StockIssuedDuringPeriodValueStockOptionsAndRestrictedStockUnitsNetOfForfeitures" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_StockIssuedDuringPeriodSharesPayoffOfConvertibleSecurities" name="StockIssuedDuringPeriodSharesPayoffOfConvertibleSecurities" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_StockIssuedDuringPeriodValuePayoffOfConvertibleSecurities" name="StockIssuedDuringPeriodValuePayoffOfConvertibleSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_StockIssuedDuringPeriodValueMarketPriceStockPurchasePlan" name="StockIssuedDuringPeriodValueMarketPriceStockPurchasePlan" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_CumulativeLossOnAvailableForSaleSecurities" name="CumulativeLossOnAvailableForSaleSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_AtTheMarketOfferingMember" name="AtTheMarketOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ConvertibleNotesMember" name="ConvertibleNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ConvertibleNoteInterestMember" name="ConvertibleNoteInterestMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TwoThousandTwentyFourConvertibleNotesMember" name="TwoThousandTwentyFourConvertibleNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TwoThousandTwentyFourConvertibleNoteInterestMember" name="TwoThousandTwentyFourConvertibleNoteInterestMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TheMannGroupLLCMember" name="TheMannGroupLLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_StockIssuedDuringPeriodSharesMarketPriceStockPurchasePlan" name="StockIssuedDuringPeriodSharesMarketPriceStockPurchasePlan" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_InterestExpenseOnPromissoryNotes" name="InterestExpenseOnPromissoryNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_IncreaseDecreaseInOperatingLeaseLiabilities" name="IncreaseDecreaseInOperatingLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_IncreaseDecreaseInRecognizedLossOnPurchaseCommitments" name="IncreaseDecreaseInRecognizedLossOnPurchaseCommitments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_PurchaseOfAvailableForSaleSecurities" name="PurchaseOfAvailableForSaleSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PaymentsRelatedToEmploymentTaxesForShareBasedCompensationAndProceedsFromExerciseOfStockOptions" name="PaymentsRelatedToEmploymentTaxesForShareBasedCompensationAndProceedsFromExerciseOfStockOptions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ReclassificationOfInvestmentsFromLongTermToCurrent" name="ReclassificationOfInvestmentsFromLongTermToCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_CommonStockIssuanceToSettleEmployeeStockPurchasePlanLiability" name="CommonStockIssuanceToSettleEmployeeStockPurchasePlanLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ReclassificationOfPaycheckProtectionProgramLoanFromCurrentToLongTerm" name="ReclassificationOfPaycheckProtectionProgramLoanFromCurrentToLongTerm" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PaymentOfInterestOnSeniorConvertibleNotesThroughCommonStockIssuance" name="PaymentOfInterestOnSeniorConvertibleNotesThroughCommonStockIssuance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AtTheMarketIssuanceMember" name="AtTheMarketIssuanceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_BusinessPolicyTextBlock" name="BusinessPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_BasisOfPresentationPolicyTextBlock" name="BasisOfPresentationPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_RevenueFromContractWithCustomerFromCommercialProductSalesPolicyTextBlock" name="RevenueFromContractWithCustomerFromCommercialProductSalesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_RevenueFromContractWithCustomerFromCollaborationsAndServicesPolicyTextBlock" name="RevenueFromContractWithCustomerFromCollaborationsAndServicesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_CostOfRevenuesPolicyTextBlock" name="CostOfRevenuesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PreLaunchInventoryPolicyTextBlock" name="PreLaunchInventoryPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_LossOnPurchaseCommitmentsPolicyPolicyTextBlock" name="LossOnPurchaseCommitmentsPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_MilestoneRightsLiabilityPolicyTextBlock" name="MilestoneRightsLiabilityPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ClinicalTrialExpensePolicyTextBlock" name="ClinicalTrialExpensePolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_RecentlyIssuedAccountingStandardsPolicyTextBlock" name="RecentlyIssuedAccountingStandardsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ScheduleOfFairValueOfCashEquivalentsLongAndShortTermInvestmentsTableTextBlock" name="ScheduleOfFairValueOfCashEquivalentsLongAndShortTermInvestmentsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DepreciationExpenseRelatedToPropertyAndEquipmentTableTextBlock" name="DepreciationExpenseRelatedToPropertyAndEquipmentTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ScheduleOfAmortizationOfDebtIssuanceCostAndDebtDiscountTableTextBlock" name="ScheduleOfAmortizationOfDebtIssuanceCostAndDebtDiscountTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ScheduleOfEffectOfModificationOnTransactionPriceTableTextBlock" name="ScheduleOfEffectOfModificationOnTransactionPriceTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ScheduleOfShareBasedCompensationEmployeeStockPurchasePlanAndNonEmployeeDirectorStockAwardPlanActivityTableTextBlock" name="ScheduleOfShareBasedCompensationEmployeeStockPurchasePlanAndNonEmployeeDirectorStockAwardPlanActivityTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ScheduleOfLeaseTermAndDiscountRateTableTextBlock" name="ScheduleOfLeaseTermAndDiscountRateTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems" name="OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable" name="OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MidCapCreditFacilityMember" name="MidCapCreditFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ConvertiblePromissoryNoteMember" name="ConvertiblePromissoryNoteMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ThironaBioIncMember" name="ThironaBioIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_InsulinMember" name="InsulinMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MilestoneRightsLiabilityMember" name="MilestoneRightsLiabilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DeerfieldManagementCompanyLpMember" name="DeerfieldManagementCompanyLpMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SalesReturnPeriod" name="SalesReturnPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfEstimatedProductsReturns" name="PercentageOfEstimatedProductsReturns" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_InvestmentMaturityPeriod" name="InvestmentMaturityPeriod" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_LossOnPurchaseCommitmentsNumberOfContractsRecognized" name="LossOnPurchaseCommitmentsNumberOfContractsRecognized" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ContingentLiabilityRemainingPayableAmount" name="ContingentLiabilityRemainingPayableAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ContingentLiability" name="ContingentLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AmortizationOnInvestments" name="AmortizationOnInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_AmortizedCostMember" name="AmortizedCostMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_GrossUnrealizedHoldingLossesMember" name="GrossUnrealizedHoldingLossesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EstimatedFairValueMember" name="EstimatedFairValueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NumberOfWholesaleDistributors" name="NumberOfWholesaleDistributors" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfAccountsReceivableFromMajorCustomers" name="PercentageOfAccountsReceivableFromMajorCustomers" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfSalesFromMajorCustomers" name="PercentageOfSalesFromMajorCustomers" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_VerticePharmaLLCMember" name="VerticePharmaLLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_UnitedTherapeuticsCorporationMember" name="UnitedTherapeuticsCorporationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PercentageOfCollaborationsAndServicesNetAccountsReceivables" name="PercentageOfCollaborationsAndServicesNetAccountsReceivables" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfRevenueFromMajorCustomersCollaborationsAndServices" name="PercentageOfRevenueFromMajorCustomersCollaborationsAndServices" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PreLaunchInventoryMember" name="PreLaunchInventoryMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FurnitureFixturesAndOfficeEquipmentMember" name="FurnitureFixturesAndOfficeEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ComputerEquipmentAndSoftwareMember" name="ComputerEquipmentAndSoftwareMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_UTEquipmentMember" name="UTEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SaleLeasebackTransactionLeaseAgreementPeriods" name="SaleLeasebackTransactionLeaseAgreementPeriods" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_CasperLLCMember" name="CasperLLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CustomerDiscountsAndAllowances" name="CustomerDiscountsAndAllowances" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_CurrentPortionOfMilestoneRightLiability" name="CurrentPortionOfMilestoneRightLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_RetailInventoryPurchase" name="RetailInventoryPurchase" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DebtInstrumentMaturityMonthAndYear" name="DebtInstrumentMaturityMonthAndYear" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentFloorRate" name="DebtInstrumentFloorRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_AccruedPaidInKindInterest" name="AccruedPaidInKindInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PaycheckProtectionProgramCARESActMember" name="PaycheckProtectionProgramCARESActMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NonConvertiblePromissoryNoteMember" name="NonConvertiblePromissoryNoteMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FivePointSevenFivePercentTwoThousandTwentyFourConvertibleNotesMember" name="FivePointSevenFivePercentTwoThousandTwentyFourConvertibleNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PriorToMidcapCreditFacilityAmendmentMember" name="PriorToMidcapCreditFacilityAmendmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PriorToFirstAmendmentMember" name="PriorToFirstAmendmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearThree" name="LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearThree" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_NumberOfTradingDays" name="NumberOfTradingDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ConsecutiveTradingDays" name="ConsecutiveTradingDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentConvertibleConversionPricePercentage" name="DebtInstrumentConvertibleConversionPricePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PrincipalAmountPerShare" name="PrincipalAmountPerShare" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_MeasurementPeriodPercentage" name="MeasurementPeriodPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentInitialConversionPriceOfPremiumPercentage" name="DebtInstrumentInitialConversionPriceOfPremiumPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentOutstandingPrincipalAmountRedeemed" name="DebtInstrumentOutstandingPrincipalAmountRedeemed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PrepaymentOfSecuredLinesOfCredit" name="PrepaymentOfSecuredLinesOfCredit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_TrancheOneMember" name="TrancheOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TrancheTwoMember" name="TrancheTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TrancheThreeMember" name="TrancheThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DebtInstrumentAdvanceAvailableDate" name="DebtInstrumentAdvanceAvailableDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentExtendedInterestOnlyDate" name="DebtInstrumentExtendedInterestOnlyDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_MaximumValueOfAdditionalInvestmentLimit" name="MaximumValueOfAdditionalInvestmentLimit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DebtInstrumentMinimumUnrestrictedCashAndShortTermInvestments" name="DebtInstrumentMinimumUnrestrictedCashAndShortTermInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DebtInstrumentUnamortizedPrepaymentPenalty" name="DebtInstrumentUnamortizedPrepaymentPenalty" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DebtInstrumentPaymentNumberOfEqualMonthlyInstallments" name="DebtInstrumentPaymentNumberOfEqualMonthlyInstallments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_LineOfCreditFacilityPrincipalPaymentStartDate" name="LineOfCreditFacilityPrincipalPaymentStartDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_EarlyTerminationFeesPercentage" name="EarlyTerminationFeesPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentMinimumCashCovenant" name="DebtInstrumentMinimumCashCovenant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PrivatelyNegotiatedExchangeAgreementMember" name="PrivatelyNegotiatedExchangeAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_LoanArrangementMember" name="LoanArrangementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NonConvertibleNoteMember" name="NonConvertibleNoteMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PromissoryNotesMember" name="PromissoryNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NewLoanArrangementMember" name="NewLoanArrangementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AccruedInterestMember" name="AccruedInterestMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DebtPremiumRecognizedInAdditionalPaidInCapital" name="DebtPremiumRecognizedInAdditionalPaidInCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DebtInstrumentFairValueInExcessOfFaceAmount" name="DebtInstrumentFairValueInExcessOfFaceAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AmortizationOfDebtDiscount" name="AmortizationOfDebtDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_MilestoneRightsLiabilitiesCurrentAndNoncurrent" name="MilestoneRightsLiabilitiesCurrentAndNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PaymentForMilestoneRightsLiabilities" name="PaymentForMilestoneRightsLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_MilestoneRightLiability" name="MilestoneRightLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_LicenseAgreementMember" name="LicenseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CommercialSupplyAgreementMember" name="CommercialSupplyAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_LicenseAndDistributionAgreementMember" name="LicenseAndDistributionAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_OtherAgreementMember" name="OtherAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CoPromotionAgreementMember" name="CoPromotionAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CollaborationAndLicenseAgreementMember" name="CollaborationAndLicenseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CiplaLtdMember" name="CiplaLtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ReceptorLifeScienceIncMember" name="ReceptorLifeScienceIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_UpfrontPaymentReceived" name="UpfrontPaymentReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_MilestonePaymentReceived" name="MilestonePaymentReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_AdditionalOptionExerciseAndDevelopmentMilestonePaymentsToBeReceived" name="AdditionalOptionExerciseAndDevelopmentMilestonePaymentsToBeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_ManufacturingServicesMember" name="ManufacturingServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NextGenResearchAndDevelopmentServicesMember" name="NextGenResearchAndDevelopmentServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TransactionPriceForTheContractualObligationsMember" name="TransactionPriceForTheContractualObligationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TransactionPriceForThePerformanceObligationsMember" name="TransactionPriceForThePerformanceObligationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SupplyAndDistributionAgreementMember" name="SupplyAndDistributionAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_BiommSAMember" name="BiommSAMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AgreementAmendmentDescription" name="AgreementAmendmentDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_RevenueRemainingPerformanceObligationAnticipatedCashFlow" name="RevenueRemainingPerformanceObligationAnticipatedCashFlow" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ResearchAndDevelopmentServicesAndLicenseMember" name="ResearchAndDevelopmentServicesAndLicenseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AllocatedTransactionPrice" name="AllocatedTransactionPrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DateOfAgreementInitiationForMarketingAndDistribution" name="DateOfAgreementInitiationForMarketingAndDistribution" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_FairValueOfFinancialInstrumentsLineItems" name="FairValueOfFinancialInstrumentsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FairValueOfFinancialInstrumentsTable" name="FairValueOfFinancialInstrumentsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MannGroupConvertibleNoteMember" name="MannGroupConvertibleNoteMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NotePayablePercentageOfInterestRateChange" name="NotePayablePercentageOfInterestRateChange" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentMeasurementInputAfterChange" name="DebtInstrumentMeasurementInputAfterChange" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_SubstantialPremiumBasedOnFairValuePostModificationRecognizedAsAdditionalPaidInCapital" name="SubstantialPremiumBasedOnFairValuePostModificationRecognizedAsAdditionalPaidInCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ContolledEquityOfferingSalesAgreementMember" name="ContolledEquityOfferingSalesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AtMarketIssuanceSalesAgreementMember" name="AtMarketIssuanceSalesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CantorFitzgeraldMember" name="CantorFitzgeraldMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SalesUnderSalesAgreement" name="SalesUnderSalesAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DebtConversionConvertedInstrumentAccruedInterestOfNotesValue" name="DebtConversionConvertedInstrumentAccruedInterestOfNotesValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_MarketPriceStockPurchasePlan" name="MarketPriceStockPurchasePlan" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_SeniorConvertibleNotesMember" name="SeniorConvertibleNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CommonStockOptionsAndPerformanceBasedStockOptionAwardsMember" name="CommonStockOptionsAndPerformanceBasedStockOptionAwardsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_RestrictedStockUnitsAndMarketRestrictedStockUnitsMember" name="RestrictedStockUnitsAndMarketRestrictedStockUnitsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EmployeeStockPurchasePlanMember" name="EmployeeStockPurchasePlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_WarrantsAssociatedWithMidcapCreditFacilityMember" name="WarrantsAssociatedWithMidcapCreditFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ShareDeliveryPercentage" name="ShareDeliveryPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ValuationAssessmentPercentage" name="ValuationAssessmentPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_EmployeeMember" name="EmployeeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedGrantsInPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedGrantsInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_EmployeeStockOptionsAndPerformanceBasedOptionsMember" name="EmployeeStockOptionsAndPerformanceBasedOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MarketRestrictedStockUnitsMember" name="MarketRestrictedStockUnitsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_RestrictedStockUnitsAndOptionsMember" name="RestrictedStockUnitsAndOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DiscountOnPurchasePricePercentageOfFairMarketValue" name="DiscountOnPurchasePricePercentageOfFairMarketValue" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_CommitmentsAndContingenciesLineItems" name="CommitmentsAndContingenciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CommitmentsAndContingenciesTable" name="CommitmentsAndContingenciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MasterLeaseAgreementWithEnterpriseMember" name="MasterLeaseAgreementWithEnterpriseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_RussellRanchRoadIILLCMember" name="RussellRanchRoadIILLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_OfficeMember" name="OfficeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_LeaseRepurchaseDescription" name="LeaseRepurchaseDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_FinanceLeaseLiabilityDiscountedPaymentsDue" name="FinanceLeaseLiabilityDiscountedPaymentsDue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PaymentOfLongTermPurchaseCommitmentAmendmentFee" name="PaymentOfLongTermPurchaseCommitmentAmendmentFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_PurchaseObligationDueInSixthYear" name="PurchaseObligationDueInSixthYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_LongTermPurchaseCommitmentExpirationDate" name="LongTermPurchaseCommitmentExpirationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_LongtermPurchaseCommitmentRenewalTimePeriod" name="LongtermPurchaseCommitmentRenewalTimePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_NumberOfVehicleLeases" name="NumberOfVehicleLeases" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_NumberOfVehicleLeasesRetired" name="NumberOfVehicleLeasesRetired" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_NumberOfVehicleLeasesReplaced" name="NumberOfVehicleLeasesReplaced" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_OperatingLeasesAnnualIncreaseInRentExpense" name="OperatingLeasesAnnualIncreaseInRentExpense" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ReimbursementAmountReceivedForTenantImprovements" name="ReimbursementAmountReceivedForTenantImprovements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_OfficeAndVehicleMember" name="OfficeAndVehicleMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</xsd:schema>
