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Collaboration, Licensing and Other Arrangements - Additional Information (Detail) - USD ($) |  | 1 Months Ended | 3 Months Ended | 12 Months Ended | 20 Months Ended |
--- | --- | --- | --- | --- | --- | ---
Oct. 31, 2021 | May 31, 2018 | Mar. 31, 2022 | Mar. 31, 2021 | Dec. 31, 2021 | Nov. 30, 2020 | Oct. 31, 2018
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Deferred revenue - current |  |  |  | $ 1,307,000 |  | $ 827,000 |  |
Deferred revenue - non-current |  |  |  | 26,116,000 |  | 19,543,000 |  |
Revenue' collaborations and services |  |  |  | 11,992,000 | $ 17,436,000 |  |  |
Collaborations and services |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Revenue' collaborations and services |  |  |  | 2,166,000 | 9,337,000 |  |  |
Commercial product sales |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Revenue' collaborations and services |  |  |  | 9,826,000 | 8,099,000 |  |  |
Collaboration and License Agreement | United Therapeutics Corporation |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Upfront payment received |  |  |  |  |  |  |  | $ 45,000,000.0
Milestone Payment Received |  |  |  |  |  |  | $ 12,500,000 |
Total anticipated cash flow | [1] | $ 463,500,000 |  |  |  |  |  |
Deferred revenue |  |  |  | 25,700,000 |  |  |  |
Deferred revenue - current |  |  |  | 1,100,000 |  |  |  |
Deferred revenue - non-current |  |  |  | 24,600,000 |  |  |  |
Collaboration and License Agreement | United Therapeutics Corporation | Manufacturing Services |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Allocated transaction price |  | 144,500,000 |  |  |  |  |  |
Collaboration and License Agreement | United Therapeutics Corporation | Manufacturing Services | Transaction Price For The Contractual Obligations |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Total anticipated cash flow |  | 64,300,000 |  |  |  |  |  |
Collaboration and License Agreement | United Therapeutics Corporation | Next-Gen R&D Services | Transaction Price For The Performance Obligations |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Total anticipated cash flow |  | $ 399,200,000 |  |  |  |  |  |
Collaboration and License Agreement | United Therapeutics Corporation | Maximum |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Additional option exercise and development milestone payments to be receive |  |  |  | $ 40,000,000.0 |  |  |  |
Commercial Supply Agreement |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Amendment description |  |  |  | As amended in October 2021, the term of the CSA continues until December 31, 2031 (unless earlier terminated) and is thereafter renewed automatically for additional, successive two-year terms unless (i) United Therapeutics provides notice to the Company at least 24 months in advance of such renewal that United Therapeutics does not wish to renew the CSA or (ii) the Company provides notice to United Therapeutics at least 48 months in advance of such renewal that the Company does not wish to renew the CSA. |  |  |  |
Commercial Supply Agreement | United Therapeutics Corporation | Collaborations and services |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Revenue' collaborations and services | [2] |  |  | $ 694,000 |  |  |  |
Co-Promotion Agreement | Collaborations and services |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Reserve for allowance for credit losses |  |  |  | 800,000 |  |  |  |
Supply and Distribution Agreement | Commercial product sales | Biomm |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Revenue' collaborations and services |  |  |  | 0 |  | $ 0 |  |
License and Distribution Agreement | Cipla Ltd |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Deferred revenue |  |  |  | 1,600,000 |  |  |  |
Deferred revenue - current |  |  |  | 100,000 |  |  |  |
Deferred revenue - non-current |  |  |  | 1,500,000 |  |  |  |
Marketing and distribution agreement date |  |  | 2018-05 |  |  |  |  |
License and Distribution Agreement | Collaborations and services | Cipla Ltd |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Revenue' collaborations and services |  |  |  | $ 37,000 | $ 36,000 |  |  |
[1] | The total anticipated cash flow includes a transaction price of $64.3 million for the contractual obligations under the CSA for the Manufacturing Services and the Next-Gen R&D Services performance obligations and $399.2 million for future supply of Tyvaso DPI over the remaining term of the CSA.
[2] | Amount consists of revenue recognized for Manufacturing Services for the three months ended March 31, 2022

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