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Description of Business and Significant Accounting Policies - Additional Information (Detail) | 1 Months Ended | 3 Months Ended |  |  |
--- | --- | --- | --- | --- | ---
Jan. 31, 2022 USD ($) | Jun. 30, 2021 USD ($) | Apr. 30, 2021 USD ($) | Mar. 31, 2021 USD ($) | Mar. 31, 2022 USD ($) Segment Contract | Dec. 31, 2021 USD ($) | Aug. 31, 2019 USD ($) | Jul. 01, 2013 USD ($)
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Accumulated deficit |  |  |  |  |  | $ (3,156,067,000) | $ (3,130,069,000) |  |
Principal amount |  |  |  |  |  | 288,400,000 |  |  |
Cash and cash equivalents |  |  |  |  | $ 247,833,000 | 67,243,000 | 124,184,000 |  |
Short-term investments |  |  |  |  |  | 95,203,000 | 79,932,000 |  |
Long-term investments |  |  |  |  |  | $ 70,542,000 | 56,619,000 |  |
Debt issuance amount |  |  |  |  | $ 230,000,000.0 |  |  |  |
Debt issuance percentage |  |  |  |  | 2.50% |  |  |  |
Number of operating segment | Segment |  |  |  |  |  | 1 |  |  |
Convertible Promissory Note | Thirona Bio, Inc. |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Investment securities |  | $ 5,000.0 | $ 3,000.0 |  |  | $ 6,900,000 | 3,000,000.0 |  |
Proceeds from investment securities |  | $ 5,000.0 | $ 3,000.0 |  |  |  |  |  |
Maturity date |  |  | 2023-12 |  |  |  |  |  |
Interest rate |  |  | 6.00% |  |  |  |  |  |
Insulin |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Loss on purchase commitments |  |  |  |  |  | $ 79,300,000 | 82,800,000 |  |
Loss on purchase commitments, number of new contracts recognized | Contract |  |  |  |  |  | 0 |  |  |
Maximum | AFREZZA product sales |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Sales return right following product expiration in months |  |  |  |  |  | 12 months |  |  |
Minimum | AFREZZA product sales |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Sales return right following product expiration in months |  |  |  |  |  | 6 months |  |  |
MidCap Credit Facility |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Principal amount | [1] |  |  |  |  | $ 40,000,000.0 | $ 40,000,000.0 |  |
Principal amount |  |  |  |  |  |  |  | $ 100,000,000.0 |
Amount outstanding |  |  |  |  |  | 40,000,000.0 |  |  |
Principal prepayment against outstanding term loans |  |  |  | $ 10,000,000.0 |  |  |  |  |
Milestone Rights Liability | Deerfield Management Company Lp |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Contingent liability remain payable |  |  |  |  |  | $ 65,000,000.0 |  |  | $ 65,000,000.0
Milestone Rights Liability | Maximum | Deerfield Management Company Lp |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Contingent liability for milestone payments |  |  |  |  |  |  |  |  | $ 90,000,000.0
[1] | In April 2021, the Company prepaid $10.0 million principal balance and amended the MidCap credit facility. The interest rate prior to the amendment was one-month LIBOR (2% floor) plus 6.75% and the maturity date was in August 2024.

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