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Condensed Consolidated Statements of Stockholders' Deficit - USD ($) $ in Thousands | Total | Mann Group | Convertible Note Mann Group | Convertible Note Interest Mann Group | 2024 Convertible Notes | 2024 Convertible Note Interest | At-the-market Placement | Common Stock | Common Stock Mann Group | Common Stock Convertible Note Mann Group | Common Stock Convertible Note Interest Mann Group | Common Stock 2024 Convertible Notes | Common Stock 2024 Convertible Note Interest | Common Stock At-the-market Placement | Additional Paid-in Capital | Additional Paid-in Capital Mann Group | Additional Paid-in Capital Convertible Note Mann Group | Additional Paid-in Capital Convertible Note Interest Mann Group | Additional Paid-in Capital 2024 Convertible Notes | Additional Paid-in Capital 2024 Convertible Note Interest | Additional Paid-in Capital At-the-market Placement | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
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Beginning Balance at Dec. 31, 2020 | $ (180,419) |  |  |  |  |  |  | $ 2,421 |  |  |  |  |  |  | $ 2,866,303 |  |  |  |  |  |  |  | $ (3,049,143)
Beginning Balance (in shares) at Dec. 31, 2020 |  |  |  |  |  |  |  | 242,118,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units | 397 |  |  |  |  |  |  | $ 4 |  |  |  |  |  |  | 393 |  |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units (in shares) |  |  |  |  |  |  |  | 390,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 1,935 |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,935 |  |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 390 |  |  |  |  |  |  | $ 3 |  |  |  |  |  |  | 387 |  |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  |  |  |  |  | 293,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock pursuant to conversion notes |  |  | $ 9,573 | $ 427 | $ 5,000 |  |  |  |  | $ 38 | $ 2 | $ 17 |  |  |  |  | $ 9,535 | $ 425 | $ 4,983 |  |  |  |
Issuance of common stock pursuant to conversion notes (in shares) |  |  |  |  |  |  |  |  |  | 3,830,000 | 170,000 | 1,667,000 |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock pursuant to payoff of the 2024 convertible note interest |  |  |  |  |  | $ 143 |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 143 |  |  |
Issuance of common stock pursuant to payoff of the 2024 convertible note interest (in shares) |  |  |  |  |  |  |  |  |  |  |  |  | 27,000 |  |  |  |  |  |  |  |  |  |
Issuance of at-the-market placement |  |  |  |  |  |  | $ 1,886 |  |  |  |  |  |  | $ 6 |  |  |  |  |  |  | $ 1,880 |  |
Issuance of at-the-market placement (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  | 578,000 |  |  |  |  |  |  |  |  |
Issuance costs associated with at-the- market placement | (38) |  |  |  |  |  |  |  |  |  |  |  |  |  | (38) |  |  |  |  |  |  |  |
Net loss | (12,916) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (12,916)
Ending Balance at Mar. 31, 2021 | (173,622) |  |  |  |  |  |  | $ 2,491 |  |  |  |  |  |  | 2,885,946 |  |  |  |  |  |  |  | (3,062,059)
Ending Balance (in shares) at Mar. 31, 2021 |  |  |  |  |  |  |  | 249,073,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning Balance at Dec. 31, 2020 | (180,419) |  |  |  |  |  |  | $ 2,421 |  |  |  |  |  |  | 2,866,303 |  |  |  |  |  |  |  | (3,049,143)
Beginning Balance (in shares) at Dec. 31, 2020 |  |  |  |  |  |  |  | 242,118,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  |  |  |  |  | 527,049 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (52,865) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance at Sep. 30, 2021 | (184,688) |  |  |  |  |  |  | $ 2,502 |  |  |  |  |  |  | 2,914,818 |  |  |  |  |  |  |  | (3,102,008)
Ending Balance (in shares) at Sep. 30, 2021 |  |  |  |  |  |  |  | 250,246,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning Balance at Mar. 31, 2021 | (173,622) |  |  |  |  |  |  | $ 2,491 |  |  |  |  |  |  | 2,885,946 |  |  |  |  |  |  |  | (3,062,059)
Beginning Balance (in shares) at Mar. 31, 2021 |  |  |  |  |  |  |  | 249,073,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units | (545) |  |  |  |  |  |  | $ 5 |  |  |  |  |  |  | (550) |  |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units (in shares) |  |  |  |  |  |  |  | 520,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 3,926 |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,926 |  |  |  |  |  |  |  |
Premium on Mann Group convertible note |  | $ 22,107 |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 22,107 |  |  |  |  |  |  |
Issuance of common stock from market price stock purchase plan | 106 |  |  |  |  |  |  |  |  |  |  |  |  |  | 106 |  |  |  |  |  |  |  |
Issuance of common stock from Market Price Stock Purchase Plan (in shares) |  |  |  |  |  |  |  | 25,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (35,523) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (35,523)
Ending Balance at Jun. 30, 2021 | (183,551) |  |  |  |  |  |  | $ 2,496 |  |  |  |  |  |  | 2,911,535 |  |  |  |  |  |  |  | (3,097,582)
Ending Balance (in shares) at Jun. 30, 2021 |  |  |  |  |  |  |  | 249,618,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units | 700 |  |  |  |  |  |  | $ 2 |  |  |  |  |  |  | 698 |  |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units (in shares) |  |  |  |  |  |  |  | 234,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock associated with debt interest payment | (590) |  |  |  |  |  |  | $ 4 |  |  |  |  |  |  | (594) |  |  |  |  |  |  |  |
Issuance of common stock associated with debt interest payment (in shares) |  |  |  |  |  |  |  | 394,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 3,179 |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,179 |  |  |  |  |  |  |  |
Net loss | (4,426) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (4,426)
Ending Balance at Sep. 30, 2021 | (184,688) |  |  |  |  |  |  | $ 2,502 |  |  |  |  |  |  | 2,914,818 |  |  |  |  |  |  |  | (3,102,008)
Ending Balance (in shares) at Sep. 30, 2021 |  |  |  |  |  |  |  | 250,246,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning Balance at Dec. 31, 2021 | (209,349) |  |  |  |  |  |  | $ 2,515 |  |  |  |  |  |  | 2,918,205 |  |  |  |  |  |  |  | (3,130,069)
Beginning Balance (in shares) at Dec. 31, 2021 |  |  |  |  |  |  |  | 251,478,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units | 129 |  |  |  |  |  |  | $ 4 |  |  |  |  |  |  | 125 |  |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units (in shares) |  |  |  |  |  |  |  | 450,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 2,806 |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,806 |  |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 740 |  |  |  |  |  |  | $ 2 |  |  |  |  |  |  | 738 |  |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  |  |  |  |  | 233,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock from market price stock purchase plan | 684 |  |  |  |  |  |  | $ 3 |  |  |  |  |  |  | 681 |  |  |  |  |  |  |  |
Issuance of common stock from Market Price Stock Purchase Plan (in shares) |  |  |  |  |  |  |  | 252,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative loss on available-for-sale securities | (1,076) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (1,076) |
Net loss | (25,998) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (25,998)
Ending Balance at Mar. 31, 2022 | (232,064) |  |  |  |  |  |  | $ 2,524 |  |  |  |  |  |  | 2,922,555 |  |  |  |  |  |  | (1,076) | (3,156,067)
Ending Balance (in shares) at Mar. 31, 2022 |  |  |  |  |  |  |  | 252,413,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning Balance at Dec. 31, 2021 | (209,349) |  |  |  |  |  |  | $ 2,515 |  |  |  |  |  |  | 2,918,205 |  |  |  |  |  |  |  | (3,130,069)
Beginning Balance (in shares) at Dec. 31, 2021 |  |  |  |  |  |  |  | 251,478,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  |  |  |  |  | 531,419 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (69,453) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance at Sep. 30, 2022 | (237,677) |  |  |  |  |  |  | $ 2,632 |  |  |  |  |  |  | 2,960,419 |  |  |  |  |  |  | (1,206) | (3,199,522)
Ending Balance (in shares) at Sep. 30, 2022 |  |  |  |  |  |  |  | 263,156,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning Balance at Mar. 31, 2022 | (232,064) |  |  |  |  |  |  | $ 2,524 |  |  |  |  |  |  | 2,922,555 |  |  |  |  |  |  | (1,076) | (3,156,067)
Beginning Balance (in shares) at Mar. 31, 2022 |  |  |  |  |  |  |  | 252,413,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units | (377) |  |  |  |  |  |  | $ 8 |  |  |  |  |  |  | (385) |  |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units (in shares) |  |  |  |  |  |  |  | 833,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 4,422 |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,422 |  |  |  |  |  |  |  |
Issuance of common stock pursuant to conversion notes |  | $ 520 | $ 9,596 |  |  |  |  |  | $ 2 | $ 39 |  |  |  |  |  | $ 518 | $ 9,557 |  |  |  |  |  |
Issuance of common stock pursuant to conversion notes (in shares) |  |  |  |  |  |  |  |  | 193,000 | 3,838,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative loss on available-for-sale securities | (130) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (130) |
Net loss | (29,023) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (29,023)
Ending Balance at Jun. 30, 2022 | (247,056) |  |  |  |  |  |  | $ 2,573 |  |  |  |  |  |  | 2,936,667 |  |  |  |  |  |  | (1,206) | (3,185,090)
Ending Balance (in shares) at Jun. 30, 2022 |  |  |  |  |  |  |  | 257,277,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units | (192) |  |  |  |  |  |  | $ 5 |  |  |  |  |  |  | (197) |  |  |  |  |  |  |  |
Net issuance of common stock associated with stock options and restricted stock units (in shares) |  |  |  |  |  |  |  | 495,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 3,622 |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,622 |  |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 873 |  |  |  |  |  |  | $ 3 |  |  |  |  |  |  | 870 |  |  |  |  |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  |  |  |  |  | 298,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock pursuant to conversion notes |  |  |  | $ 99 |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 99 |  |  |  |  |
Issuance of common stock pursuant to conversion notes (in shares) |  |  |  |  |  |  |  |  |  |  | 26,000 |  |  |  |  |  |  |  |  |  |  |  |
Issuance of at-the-market placement |  |  |  |  |  |  | $ 19,790 |  |  |  |  |  |  | $ 51 |  |  |  |  |  |  | $ 19,739 |  |
Issuance of at-the-market placement (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,060,000 |  |  |  |  |  |  |  |  |
Issuance costs associated with at-the- market placement | (381) |  |  |  |  |  |  |  |  |  |  |  |  |  | (381) |  |  |  |  |  |  |  |
Net loss | (14,432) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (14,432)
Ending Balance at Sep. 30, 2022 | $ (237,677) |  |  |  |  |  |  | $ 2,632 |  |  |  |  |  |  | $ 2,960,419 |  |  |  |  |  |  | $ (1,206) | $ (3,199,522)
Ending Balance (in shares) at Sep. 30, 2022 |  |  |  |  |  |  |  | 263,156,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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