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Summary of UT Revenue (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |
Total revenue from UT |  | $ 99,770 | $ 75,442 | $ 65,144
United Therapeutics Corporation |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |
Total revenue from UT |  | 42,851 | 34,412 | 32,213
United Therapeutics Corporation | Commercial Supply Agreement |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |
Total revenue from UT |  | 24,826 | 267 |
United Therapeutics Corporation | License Agreement |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |
Total revenue from UT |  | 2,426 | $ 34,145 | $ 32,213
United Therapeutics Corporation | Royalties Arrangement |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |
Total revenue from UT | [1] | $ 15,599 |  |
[1] | Amount consists of royalties associated with the UT License Agreement.

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