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Components of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 542,537 | $ 542,800
Research and development credits | 78,804 | 78,804
Capitalized research costs | 4,369 |
Milestone Rights | 1,331 | 1,440
Accrued expenses | 2,675 | 2,591
Loss on purchase commitment | 23,117 | 24,845
Non-qualified stock option expense | 7,686 | 5,684
Capitalized patent costs | 8,058 | 7,518
Other | 3,204 | 2,568
Lease liability | 1,624 | 588
Interest expense limitation | 10,991 | 5,696
Depreciation | 22,157 | 22,983
Deferred Product Revenue & Costs | 370 | 404
Total net deferred tax assets | 706,923 | 695,921
Valuation allowance | (705,034) | (695,094)
Net deferred tax assets | 1,889 | 827
Deferred tax liabilities: |  |
Right of use asset | (1,640) | (555)
Other prepaids | (249) | (272)
Total deferred tax liabilities | $ (1,889) | $ (827)

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