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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
CASH FLOWS FROM OPERATING ACTIVITIES: |  |  |
Net loss | $ (87,400) | $ (80,926) | $ (57,240)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Stock-based compensation expense | 13,447 | 12,200 | 6,511
Depreciation, amortization and accretion | 6,124 | 4,215 | 2,149
Interest expense on financing liability | 9,552 | 1,372 |
Interest on milestone right |  | 3,663 |
Write-off of inventory | 2,202 | 1,902 | 496
Interest expense on Mann Group promissory notes | 325 | 1,598 | 5,148
Amortization of right-of-use assets | 2,987 | 1,258 | 1,177
Loss on available-for-sale securities | 932 |  |
Loss on extinguishment of debt, net |  | 17,200 | 264
Asset impairment |  | 106 | 1,889
(Gain) loss on foreign currency translation | (4,811) | (6,567) | 8,006
In-process research and development |  |  | 13,233
Other, net | 17 |  | 19
Changes in operating assets and liabilities: |  |  |
Accounts receivable, net | (11,807) | (776) | (705)
Inventory | (5,670) | (4,081) | (1,314)
Prepaid expenses and other current assets | (15,552) | (360) | (154)
Other assets | 523 | (138) | 227
Accounts payable | 4,096 | 1,374 | 793
Accrued expenses and other current liabilities | (723) | 8,814 | 3,346
Deferred revenue | 19,047 | (14,567) | (5,910)
Recognized loss on purchase commitments | (5,709) | (5,892) | (4,751)
Operating lease liabilities | (3,309) | (2,135) | (1,312)
Accrued interest on Mann Group promissory notes |  | (4,919) |
Deposits from customer | (4,950) | 4,950 |
Net cash used in operating activities | (80,679) | (61,709) | (28,128)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |  |
Purchase of held-to-maturity debt securities | (74,536) | (196,131) |
Proceeds from maturity of debt securities | 107,340 | 59,060 |
Acquisition of V-Go | (15,341) |  |
Purchase of property and equipment | (7,589) | (11,466) | (801)
Purchase of available-for-sale securities | (5,000) | (3,000) |
Proceeds from sale of treasury bills |  |  | 20,000
Acquisition of in-process research and development, net of cash acquired |  |  | (3,983)
Net cash provided by (used in) investing activities | 4,874 | (151,537) | 15,216
CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |
Milestone payment | (1,088) | (5,000) |
Issuance costs associated with the sale-leaseback transaction |  | (3,120) |
Net issuance of common stock associated with stock options and restricted stock units | 319 | (498) | 233
Proceeds from market price stock purchase plan and from employee stock purchase plan | 2,766 | 106 | 215
Payment on financing liability | (18) |  |
Issuance of common stock from the exercise of warrants |  |  | 11,600
Proceeds from MidCap credit facility |  |  | 10,000
Proceeds from PPP loan |  |  | 4,873
Proceeds from the Senior convertible notes |  | 230,000 |
Issuance costs associated with Senior convertible notes |  | (7,268) |
Proceeds from the sale-leaseback transaction |  | 102,250 |
Deposit for the sale-leaseback transaction |  | (2,000) |
Principal payments on Mann Group promissory notes |  | (35,051) |
Payment of MidCap credit facility |  | (10,000) |
Payment of MidCap credit facility prepayment penalty |  | (1,000) |
Net cash provided by financing activities | 21,388 | 270,267 | 49,853
NET INCREASE IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH | (54,417) | 57,021 | 36,941
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD | 124,184 | 67,163 | 30,222
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD | 69,767 | 124,184 | 67,163
SUPPLEMENTAL CASH FLOWS DISCLOSURES: |  |  |
Interest paid in cash | 8,852 | 11,268 | 3,558
NON-CASH INVESTING AND FINANCING ACTIVITIES: |  |  |
Reclassification of investments from long-term to current | 82,850 | 32,654 |
Reclassification of Thirona convertible notes and interest receivable from long-term to current | 7,375 |  |
Payments on debt and interest through common stock issuance | 10,270 | 15,143 | 15,549
Forgiveness of PPP loan |  | (4,873) |
Addition of right-of-use-asset | 1,812 | 1,425 |
Right-of-use asset modification | 3,793 | 278 |
Non-cash construction in progress and property and equipment | 1,298 | 1,264 | 92
Issuance of common stock under Employee Stock Purchase Plan |  | 1,090 | 684
Contingent milestone liability | 610 |  |
Issuance of common stock for acquisition of in-process research and development |  |  | 9,250
Issuance of warrants associated with the MidCap Credit Facility |  |  | 275
Receivable from at-the-market offering |  |  | 226
The Mann Group L L C |  |  |
NON-CASH INVESTING AND FINANCING ACTIVITIES: |  |  |
Premium on convertible note |  | 22,107 |
At The Market Issuance |  |  |
CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |
Proceeds from public offering | 19,790 | 1,886 | 23,450
Issuance costs associated with the sale-leaseback transaction | $ (381) | $ (38) | $ (518)

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