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Income Taxes - Additional Information (Detail) - USD ($)
1 Months Ended 12 Months Ended
Aug. 31, 2004
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Income Taxes [Line Items]        
Valuation allowance of deferred tax asset   $ 705,034,000 $ 695,094,000  
Change in the valuation allowance   9,940,000 19,631,000 $ 4,846,000
Federal operating loss carryforwards   2,200,000,000    
State operating loss carryforwards   1,700,000,000    
Federal operation loss carryforwards, not subject to expiration   $ 499,600,000    
Operating loss carryforwards, limitations on use   Pursuant to IRC Sections 382 and 383, annual use of the Company’s federal and California net operating loss and research and development credit carryforwards may be limited in the event a cumulative change in ownership of more than 50% occurs within a three-year period.    
Net operating loss carryforwards $ 105,800,000      
Net operating loss and credit carryforwards, annual use limitation $ 13,000,000.0      
Research and development credits begin to expire   2023    
Research and development credits expire   $ 1,100,000    
Unrecognized income tax interest and penalties   0 $ 0 $ 0
Federal        
Income Taxes [Line Items]        
Research and development credits not expire   $ 54,200,000    
Research and development credits begin to expire   2024    
State        
Income Taxes [Line Items]        
Research and development credits not expire   $ 24,600,000    
New Jersey        
Income Taxes [Line Items]        
Research and development credits begin to expire   2023    
Connecticut        
Income Taxes [Line Items]        
Research and development credits not expire   $ 19,800,000    
California        
Income Taxes [Line Items]        
Research and development credits not expire   $ 200,000