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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Revenues:      
Total revenues $ 99,770 $ 75,442 $ 65,144
Expenses:      
Cost of goods sold 16,003 16,833 15,084
In-process research and development     13,233
Research and development 19,721 12,312 6,248
Selling 53,753 45,528 34,365
General and administrative 37,720 31,889 24,675
Asset impairment   106 1,889
(Gain) loss on foreign currency translation (4,811) (6,567) 8,006
Loss on purchase commitments   339  
Total expenses 163,880 122,464 113,057
Loss from operations (64,110) (47,022) (47,913)
Other (expense) income:      
Interest income, net 2,513 112 167
Interest expense on financing liability (9,758) (1,373)  
Interest expense on notes (15,011) (15,204) (9,471)
Loss on available-for-sale securities (932)    
Loss on extinguishment of debt   (17,200) (264)
Other (expense) income (102) (239) 23
Total other expense (23,290) (33,904) (9,545)
Loss before income tax expense (87,400) (80,926) (57,458)
Benefit from income taxes 0 0 218
Net loss $ (87,400) $ (80,926) $ (57,240)
Net loss per share - basic $ (0.34) $ (0.32) $ (0.26)
Net loss per share - diluted $ (0.34) $ (0.32) $ (0.26)
Shares used to compute net loss per share - basic 257,092 249,244 222,585
Shares used to compute net loss per share - diluted 257,092 249,244 222,585
Commercial product sales      
Revenues:      
Total revenues $ 56,247 $ 39,168 $ 32,324
Collaborations and services      
Revenues:      
Total revenues 27,924 36,274 32,820
Expenses:      
Cost of revenue 41,494 $ 22,024 $ 9,557
Royalty collaborations      
Revenues:      
Total revenues $ 15,599