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Investments - Additional Information (Detail) - USD ($)
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Schedule Of Investments [Line Items]    
Cash and cash equivalents $ 69,767,000 $ 124,184,000
Short-term investments 101,079,000 79,932,000
Long-term investments 1,961,000 56,619,000
Accretion or amortization 700,000 500,000
Allowance for credit losses on held-to-maturity securities 0 0
Accrued interest receivable 600,000 300,000
Amount receivable on matured investment 5,100,000  
Held-to-Maturity Investments    
Schedule Of Investments [Line Items]    
Short-term investments 101,100,000 79,900,000
Long-term investments 2,000,000.0 56,600,000
Convertible Promissory Note | Thirona Bio Inc    
Schedule Of Investments [Line Items]    
Investment securities 7,100,000  
Available-for-Sale Investment, credit losses 900,000  
Money Market Funds    
Schedule Of Investments [Line Items]    
Cash and cash equivalents $ 69,800,000 $ 124,200,000